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Chiral MOF-graphene hybrid material, and preparation method and application thereof

A graphene and MOF- technology, which is applied in the field of chiral MOF-graphene hybrid materials and their preparation, can solve the problems of infant teratogenicity and insufficient understanding of biological activity, and achieves wide detection range, easy operation and simple preparation method. Effect

Inactive Publication Date: 2017-12-19
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, in the "thalidomide" incident that occurred in the 1950s, a drug called thalidomide had the effect of alleviating pregnancy reactions, but due to the lack of understanding of the different biological activities of chiral drugs in the human body at that time, 12,000 babies died. Teratogenic

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 A kind of preparation method of chiral MOF-graphene hybrid material

[0029] After blending the alkaline aqueous solution of L-aspartic acid with the aqueous solution of copper nitrate-graphene oxide, add the ethanol solution of 4,4´-bipyridine, let stand overnight, centrifuge and wash with ethanol 3 times, made by drying;

[0030] The alkaline aqueous solution of L-aspartic acid is prepared by dissolving 0.0200-g sodium hydroxide and 0.0200 g L-aspartic acid in 1 mL of water;

[0031] The aqueous solution of copper nitrate-graphene oxide is prepared by dissolving 0.53 g of copper nitrate in 6 mL of water, adding 0.010 g of graphene oxide, and ultrasonicating for 30 min;

[0032] The ethanol solution of 4,4-bipyridine is prepared by dissolving 0.050 g of 4,4′-bipyridine in 0.75 mL of ethanol.

Embodiment 2

[0033] Embodiment 2. A kind of preparation method of chiral MOF-graphene hybrid material

[0034] After blending the alkaline aqueous solution of L-aspartic acid with the aqueous solution of copper nitrate-graphene oxide, add the ethanol solution of 4,4´-bipyridine, let stand overnight, centrifuge and wash with ethanol 3 times, made by drying;

[0035] The alkaline aqueous solution of L-aspartic acid is prepared by dissolving 0.035 g sodium hydroxide and 0.0340 g L-aspartic acid in 1.5 mL water;

[0036] The aqueous solution of copper nitrate-graphene oxide is prepared by dissolving 0.73 g of copper nitrate in 8 mL of water, adding 0.020 g of graphene oxide, and ultrasonicating for 30 min;

[0037] The ethanol solution of 4,4-bipyridine is prepared by dissolving 0.66 g of 4,4′-bipyridine in 1.25 mL of ethanol.

Embodiment 3

[0038] Embodiment 3. A kind of preparation method of chiral MOF-graphene hybrid material

[0039] After blending the alkaline aqueous solution of L-aspartic acid with the aqueous solution of copper nitrate-graphene oxide, add the ethanol solution of 4,4´-bipyridine, let stand overnight, centrifuge and wash with ethanol 3 times, made by drying;

[0040] The alkaline aqueous solution of the L-aspartic acid is prepared by dissolving 0.028 g of sodium hydroxide and 0.027 g of L-aspartic acid in 1.3 mL of water;

[0041] The aqueous solution of copper nitrate-graphene oxide is prepared by dissolving 0.60 g of copper nitrate in 7 mL of water, adding 0.015 g of graphene oxide, and ultrasonicating for 30 min;

[0042] The ethanol solution of 4,4-bipyridine is prepared by dissolving 0.058 g of 4,4′-bipyridine in 1.0 mL of ethanol.

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Abstract

The invention discloses a chiral MOF-graphene hybrid material, a preparation method thereof, and the application of the chiral MOF-graphene hybrid material to the detection of chiral drug enantiomers, and belongs to the technical fields of nanometer composite materials, macromolecule-based composite materials, graphene-based composite materials and chiral sensing detection. The method comprises the following main steps: blending an alkaline aqueous solution of L-aspartic acid and an aqueous solution of cupric nitrate-graphene oxide, adding an ethanol solution of 4, 4'-bipyridine, leaving the mixture to stand over a night, performing centrifugal separation, washing and drying, so as to obtain the chiral MOF-graphene hybrid material. A chiral MOF-graphene hybrid material sensor constructed through the hybrid material is applied to the sensitive detection of the contents of R-2-amino-3-phenylpropionic acid and S-2-amino-3-phenylpropionic acid enantiomers.

Description

technical field [0001] The invention relates to a chiral MOF-graphene hybrid material and its preparation method and application, and belongs to the technical field of nanomaterials, metal organic complex nanomaterials and chiral sensing and detection. Background technique [0002] Chirality is one of the essential properties of nature. The property that a compound molecule and its mirror image cannot be completely superimposed is called chirality. Chirality exists widely in nature. For example, amino acids in human body are all in L configuration, and glucose in plants in nature is in D configuration. Many pharmaceuticals, nutraceuticals, and pesticides have a set of enantiomers that are mirror images, but these enantiomers often exhibit different biological activities and pharmacological responses. For example, in the "thalidomide" incident that occurred in the 1950s, a drug called thalidomide had the effect of alleviating pregnancy reactions, but due to the lack of under...

Claims

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Application Information

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IPC IPC(8): G01N27/30G01N27/36G01N27/26
Inventor 匡轩魏琴孙旭张勇
Owner UNIV OF JINAN
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