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Preparation method of pyriproxyfen

A technology of pyriproxyfen and propanol, which is applied in the field of agricultural chemistry, can solve problems such as cumbersome methods and severe reaction conditions, and achieve the effects of increasing reaction yield, simplifying operation steps, and facilitating industrial production

Inactive Publication Date: 2017-12-15
NANTONG PAISIDI PESTICIDE CHEM
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Problems solved by technology

[0004] And the synthetic method of existing pyriproxyfen, method is all more loaded down with trivial details, and reaction condition is more intense

Method used

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Embodiment Construction

[0015] The following examples can enable those skilled in the art to understand the present invention more comprehensively, but the present invention is not limited to the scope of the described examples.

[0016] A preparation method of pyriproxyfen, using 4-phenoxyphenol (referred to as POP) as raw material to synthesize intermediate 1-(4-phenoxyphenoxy) 2-propanol (referred to as PPP), the intermediate PPP is not After separation, directly synthesize pyriproxyfen with 2-chloropyridine after toluene solvent treatment, the steps are as follows:

[0017] (1) Put 32.08 g (0.55 mol) potassium hydroxide and 300 mL water into a 1000 mL four-necked flask, stir and dissolve, then slowly add 93 g (0.5 mol) 4-phenoxyphenol, heat After reaching 60°C, cool down to 10°C in an ice bath, add 31.9g (0.55mol) of propylene oxide dropwise, and continue the reaction at 10-20°C for 4 hours until the end;

[0018] (2) Add 400ml of toluene, heat up to 50°C to remove the water layer, add 32.08g (0...

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Abstract

The invention relates to a preparation method of pyriproxyfen. The preparation method comprises the following steps of using POP (4-phenoxyphenol) as the raw material to synthesize an intermediate, namely 1-(4-phenoxyl phenoxyl)2-propanol; treating the intermediate by methylbenzene solvent without separating, and directly synthesizing with 2-chloropyridine, so as to obtain the pyriproxyfen. The preparation method has the advantages that the route and the method are simple, the conditions are moderate, the operation steps are simplified, the reaction yield rate is increased, the preparation method is more suitable for industrialized production, the total yield rate of synthesis reaches 85.5% on the basis of POP, and the content of crude drug is greater than or equal to 97%.

Description

technical field [0001] The invention belongs to the field of agricultural chemistry, in particular to a preparation method of pyriproxyfen. Background technique [0002] Pyriproxyfen is an insect growth regulator with juvenile hormone activity, developed by Japan Tomo Chemical Co., Ltd. It can be used to control agricultural pests of Homoptera, Thysanoptera, Diptera, and Lepidoptera. In addition to having high activity against whitefly and greenhouse whitefly, it is also effective against scale insects such as pear yellow psyllid, red garden scale, peach aphid, Agricultural pests such as Spodoptera litura and potato beetle have good control effects. [0003] As the world pays more and more attention to environmental protection, the demand for low-toxicity, high-efficiency, and environmentally friendly pesticides is increasing year by year, and pesticides with high toxicity, high residues, and large impact on the ecological environment will be eliminated. Pyriproxyfen as An...

Claims

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Application Information

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IPC IPC(8): C07D213/64
CPCC07D213/64
Inventor 唐志军
Owner NANTONG PAISIDI PESTICIDE CHEM
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