Coumarin eye drops and preparation method

Abstract

The invention discloses a coumarin eye drop and a preparation method thereof, and relates to the technical field of medicine preparation. The coumarin eye drop of the invention comprises a coumarin extract, an eye lubricant: carboxymethyl cellulose, and a buffer: The mixed solution of NaHCO3 and KCl, preservative: benzalkonium bromide, coumarin eye drops of the present invention For the dry eye syndrome of rabbits caused by atmospheric particulate matter PM, coumarin eye drops can improve the effect of dry eye rapidly and obviously. Symptoms and maintenance tear protein components are a safe and effective method for treating dry eye with simple administration routes and few side effects, and patients can persist for a long time. It has wide clinical application and promotion value. And study its intervention mechanism to discuss its receptors, signal transduction pathways, regulatory mechanisms and related clinical applications, which may provide new ways to explore therapeutic strategies for anti-ocular inflammation, neovascular lesions and degenerative eye diseases.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a coumarin eye drop and a preparation method thereof. Background technique [0002] Dry eye syndrome is an unstable tear film and ocular surface damage caused by abnormal tear quantity or quality, which seriously affects the vision and life of patients, and the prevalence rate is increasing year by year. In recent years, air pollution has become one of the most important issues in the field of global public health. The ocular surface is directly exposed to the external environment, and atmospheric particles are closely related to the occurrence and development of ocular surface diseases. Chang et al reported that air pollution was positively associated with the number of outpatients with nonspecific conjunctivitis in Taiwan. Air pollution can lead to ocular surface irritation symptoms, decreased tear film stability, goblet cell hyperplasia and other changes. Studie...

AI Technical Summary

Problems solved by technology

Torricelli AA et al. found that taxi drivers and traffic managers exposed to air pollution had decreased tear film stability and affected tear permeability

Tau J et al. showed that oil extraction machine exhaust particles selectively induce the expression of pro-inflammatory cytokines and mucins in human corneal and conjunctival epithelial cells, resulting in ocular discomfort

Through experiments at the cellular level, GaoZX et al. believe that PM2.5 can cause DNA damage and cell aging in corneal epithelial cells by promoting the generation of oxygen free radicals, leading to the formation of dry eye syndrome

There is currently no research on patients with dry eye caused by atmospheric particles. Therefore, finding a drug that can treat dry eye caused by atmospheric particles has become an urgent problem in ophthalmology.