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External preparation for killing bacteria, relieving itching and remaining fragrance

An external preparation, the technology of sandalwood, applied in the directions of medical preparations containing active ingredients, antifungal agents, non-central pain relievers, etc., can solve the problems of patients with drug withdrawal, large side effects, and low efficiency of superficial skin.

Active Publication Date: 2017-12-01
胡羽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many traditional Chinese medicines for treating ringworm on the market, such as Huangfule Ointment, Ringworm Yaogan, Nianxuanjing, etc., have unstable and accurate curative effects, and patients often need to change the drugs several times
Oral antifungal drugs have relatively large side effects, often causing patients to stop taking the drug halfway, and the efficiency of acting on the superficial skin is very low, and the curative effect is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 external preparation of the present invention

[0025] Liniment Formulation Preparation

[0026] (1) Weigh the raw materials in the following parts by weight: 30 yellow grass, 15 magnolia, 15 rose, 18 sandalwood, 12 chuanjinwen, 9 Kaempferia, 90 Angelica dahurica, 36 Gujingcao, 36 mulberry leaves, and 36 cassia seeds , white chrysanthemum 36, green bark 45, earth vitex bark 15, bauhinia bark 15, neem root 18, daughter 50, cantharidin 90, centipede 60, camphor 300;

[0027] (2) Grinding the crude drug into 10 mesh coarse particles, and putting it into a glass jar;

[0028] (3) adding 75% ethanol whose weight is 15 times of bulk drug to the container and sealing;

[0029] (4) Soak for 10 days, during which time shake once a day;

[0030] (5) 50 mesh filter cloths filter and collect the filtrate;

[0031] (6) Pack into the liniment container.

[0032] Preparation of ointment dosage forms

[0033] (1) Weigh the raw materials in the foll...

Embodiment 2

[0038] The antibacterial effect of embodiment 2 external preparations of the present invention

[0039] Experimental Drugs:

[0040] Binghuangfule ointment (Tibet Zhizhi Pharmaceutical Co., Ltd.).

[0041] Chinese medicinal ointment for external use of the present invention prepared by the method of Example 1.

[0042] Experimental strains:

[0043] Representative strains of common dermatophytes isolated from the Dermatology Department of Shaanxi Provincial People's Hospital:

[0044] Trichophyton rubrum (T.rubrum), Epidermophyton flocculus (E.floccosum), Microsporum gypsum (M.gypseum). Experiment medium:

[0045] Sandcastle's Tween 80 liquid, Sandcastle's Tween 80 agar medium (Sabburg's medium was added with 5‰ Tween 80).

[0046] Calculation of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC):

[0047] The experimental drugs were diluted with Sandcastle's Tween 80 liquid medium to make the final concentrations respectively 100, 80, 60...

Embodiment 3

[0057] Embodiment 3 antipruritic effect of external preparation of the present invention

[0058] Experimental Drugs:

[0059] Calcipotriol Ointment / Dalex (Ireland Leo Pharmaceuticals)

[0060] Binghuangfule ointment (Tibet Zhizhi Pharmaceutical Co., Ltd.).

[0061] Chinese medicinal external liniment of the present invention prepared by the method of Example 1.

[0062] test subject:

[0063]40 healthy guinea pigs, half male and half male, were randomly divided into 4 groups, 10 guinea pigs in each group. They are respectively blank control group, Binghuangfule ointment group, external liniment group of the present invention, and calcipotriol ointment group.

[0064] experiment procedure:

[0065] One day before the experiment, the dorsum of the right hind foot of the guinea pigs in each test group was shaved, and then the drug was applied to the shaved area once. On the experimental day, the shaved area of ​​the right hind foot was scratched with sandpaper, with an are...

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Abstract

The invention provides an external preparation for killing bacteria, relieving itching and remaining fragrance. The external preparation is prepared from the following active pharmaceutical ingredients in parts by weight including 30 parts of herba fenugreek lysimachia, 15 parts of flos magnoliae, 15 parts of rose flowers, 18 parts of sandalwood, 12 parts of Chuanjinwen, 9 parts of rhizoma kaempferiae, 90 parts of radix angelicae, 36 parts of herba eriocaulon buergerianum, 36 parts of mulberry leaves, 36 parts of semen cassia, 36 parts of white chrysanthemum flowers, 45 parts of green tangerine orange peel, 15 parts of golden larch bark, 15 parts of cercis chinensis bark, 18 parts of melia azedarach roots, 50 parts of moleplant seeds, 90 parts of cantharides, 60 parts of centipede and 300 parts of camphor.

Description

a technical field [0001] The invention relates to the field of traditional Chinese medicine for external use, in particular, the invention relates to a traditional Chinese medicine preparation for external use which is sterilized, relieves itching and keeps fragrance. Two background technology [0002] Ringworm is a common disease in dermatology. The direct cause is a superficial fungal skin disease caused by dermatophyte infection of the skin. It is generally believed that it is often related to immune dysfunction and has a certain genetic tendency. The main clinical manifestations are papules, blisters, maceration and erosion, dry desquamation with pruritus, and the incidence rate is high in summer and autumn, and the prevalence rate of the population can reach more than half. According to its clinical manifestations, tinea can be divided into three types, namely vesicular type, impregnated erosion type and scaly keratosis type. The three types can be transformed into eac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/906A61P17/00A61P31/10A61P29/00A61P17/04A61K35/648A61K35/64A61K31/125
CPCA61K36/906A61K31/125A61K35/63A61K35/648A61K36/15A61K36/185A61K36/232A61K36/287A61K36/47A61K36/48A61K36/482A61K36/575A61K36/58A61K36/605A61K36/708A61K36/738A61K36/752A61K36/88A61K2236/39A61K2236/333A61K2300/00
Inventor 胡羽
Owner 胡羽
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