Sponge loaded chiral organic catalyst

Abstract

The invention provides a sponge loaded chiral organic catalyst. The sponge loaded chiral organic catalyst is prepared from sponge, a Linker reagent, and a catalyst. The sponge has a polymer skeleton with a 3D porous structure. The sponge contains surface groups. The Linker reagent comprises at least two active functional groups. The catalyst is a nonmetal, chiral, and organic catalyst. The Linker reagent is bonded with the surface groups of the sponge and loaded on the sponge surface through the active functional groups. The catalyst is bonded with the active functional groups of the Linker reagent and is connected to the sponge surface therefore. The chiral organic catalyst can be a proline catalyst, an alpha-amino acid catalyst, an imidazolone catalyst, an oligopeptide catalyst, a quinine catalyst, a planar chiral catalyst, a diaryl catalyst, a diamine catalyst, and other catalysts containing heterocyclic rings.

Description

technical field [0001] The invention belongs to the field of catalysts, in particular to a sponge-loaded chiral organic catalyst. Background technique [0002] Asymmetric catalysis is a difficult point in organic synthesis. Asymmetric reactions can be realized through chiral organic catalysts. Usually, the amount of catalyst is small, and the reaction can be completed with high stereoselectivity in a relatively short period of time. By loading the catalyst, the recovery of valuable or polluted catalysts can be achieved, reducing pollution and waste. However, with the continuous development of organic synthesis technology, the types of organic catalysts are constantly enriched, and there are higher requirements for the application of catalysts. Sometimes, in order to achieve asymmetric catalysis, greener reaction systems, and atomic economics, multiple organic catalysts are used in combination to perform synergistic catalysis in a single reaction system. Although these cata...

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Problems solved by technology

[0005] The object of the present invention is to provide a chiral organic catalyst supported by sponge, which aims to solve the problem that there is no chiral organic catalyst supported by sponge in the prior art, and it is difficult to ensure the activity and facilitate recovery of organic small molecule catalysts that catalyze the activation reaction of conventional C-H bonds. The problem of loading on the sponge under the premise of

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