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A preparation method of repeatedly gradient porous titanium alloy for promoting bone fusion

A gradient porous, titanium alloy technology, applied in the medical field, can solve problems such as poor tissue compatibility and large elastic modulus, increase fusion strength and pull-out force, increase growth rate and ingrowth ability, and overcome tissue compatibility poor sex effect

Active Publication Date: 2020-06-30
浙江德康医疗器械有限公司
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Problems solved by technology

[0006] In order to overcome the disadvantages of large elastic modulus and poor tissue compatibility of traditional titanium alloy materials, the present invention particularly relates to a preparation method of a repetitively gradient porous titanium alloy that promotes bone fusion

Method used

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  • A preparation method of repeatedly gradient porous titanium alloy for promoting bone fusion
  • A preparation method of repeatedly gradient porous titanium alloy for promoting bone fusion
  • A preparation method of repeatedly gradient porous titanium alloy for promoting bone fusion

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preparation example Construction

[0015] Such as figure 1 As shown, this specific embodiment provides a method for preparing a repeatedly gradient porous titanium alloy that promotes bone fusion, and the method includes the following steps:

[0016] Step 1. Establishing a 3D digital model of a repetitive gradient porous titanium alloy

[0017] In this step, a three-dimensional model of the porous titanium alloy rod is established using three-dimensional digital modeling software. Designing the three-dimensional model of the titanium alloy bar includes designing the structure and size of the bar. The porous titanium alloy rod is used to be implanted into tissue to realize the repair of bone tissue damage. A typical bar structure design such as figure 2 shown. The rod is in the shape of a rod, and a plurality of holes are formed therein, and the holes extend from the outer surface of the rod to the inside of the rod. in such as figure 2 In the shown structure, the plurality of holes on the surface of the...

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Abstract

The invention discloses a preparing method for repetitive-gradient porous titanium alloy for promoting sacralization. The repetitive-gradient porous titanium alloy takes titanium alloy powders as raw materials, and repetitive-gradient porous titanium alloy bar materials are prepared by 3D printing; elasticity modulus of the gradient porous titanium alloy is at 0.53-13.2 GPa, and the compression and flexion-extension strength is changed at 22-356 Mpa, and the elasticity modulus of the gradient porous titanium alloy is matched with the elasticity modulus of natural bones. The preparing method for the repetitive-gradient porous titanium alloy for promoting sacralization comprises the following steps that hydroxyapatite (HA) coating with bioactivity is constructed on the surface of the repetitive-gradient porous titanium alloy through a plasma spraying technique; and the growth factor (VEGF) is fixed to surfaces of materials by utilizing dopamine as an intermediate medium. The porous titanium alloy materials prepared through the preparing method is loaded with the growth factor and the HA and has the characteristics that histocompatibility is high, and migration and growth of osteocyte can be promoted; and according to the repetitive-gradient porous structure, the fusion strength of bones is increased, and pullout force is increased.

Description

technical field [0001] The invention belongs to the medical field, and in particular relates to a preparation method of a repetitive gradient porous titanium alloy for promoting bone fusion. Background technique [0002] The repair of bone tissue damage is a difficult point faced by orthopedic surgeons in their clinical work. Although autologous bone grafting is the first choice, autologous bone grafting is affected by many conditions in the actual environment, and many factors make autologous bone unable to meet clinical needs. [0003] In the prior art, simple porous metal materials are usually used to repair bone tissue damage. However, the simple porous metal material in the prior art has poor tissue compatibility, which hinders bone growth. Therefore, in the prior art, there is a need for a bone repair material that has bone repair ability, high mechanical strength, and increased bone fusion ability, which will meet the clinical demand for autologous bone. The modulu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/50A61L27/06A61L27/32A61L27/28A61L27/54
CPCA61L27/06A61L27/28A61L27/32A61L27/50A61L27/54A61L27/56A61L2300/252A61L2300/414A61L2300/606A61L2420/08A61L2430/02
Inventor 任涛许小波
Owner 浙江德康医疗器械有限公司
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