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Chromium-enriched mung bean small peptide having function of reducing blood sugar and preparation method of chromium-enriched mung bean small peptide

A chromium-enriched mung bean and hypoglycemic technology, applied in the biological field, can solve the problems of low utilization rate of chromium, restricted utilization and the like, and achieve the effects of less toxic and side effects, lowering hyperglycemia, and less residue.

Inactive Publication Date: 2017-11-17
ANHUI BIOLOGICAL PEPTIDE IND RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally speaking, the utilization rate of chromium is relatively low, which limits its utilization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034]Preparation of chromium-rich mung bean small peptide: Dissolve chromium trichloride (or chromium nicotinate, or chromium picolinate) in deionized water to prepare a solution with a concentration of 12 mg / ml, and the ratio of solution to mung bean protein is 10:1 Add mung bean protein, stir evenly, heat and boil for 15 minutes, wait to cool to about 45°C, adjust the pH value to 2.0 with dilute hydrochloric acid, add 1.5% pepsin, keep warm for 2 hours, adjust the pH value to 8.0, add 1.0% trypsin, and keep warm for 4 hour, boiled for 15 minutes, centrifuged, and the precipitate was discarded. The supernatant was ultrafiltered through an ultrafiltration membrane with a relative molecular mass of 3KD, and the permeate was added to a DA201-C macroporous adsorption resin column, eluted with water, and discarded. Wash the solution with water, then elute with 75% (V / V) ethanol, collect the ethanol eluate, recover the ethanol under reduced pressure and continue to concentrate to a...

Embodiment 2

[0036] Preparation of chromium-rich mung bean small peptide: Dissolve chromium trichloride (or chromium nicotinate, or chromium picolinate) in deionized water to prepare a solution with a concentration of 14 mg / ml, according to the ratio of solution to mung bean protein ratio of 8:1 Add mung bean protein, stir evenly, heat and boil for 10 minutes, wait to cool to about 50°C, adjust the pH value to 3.0 with dilute hydrochloric acid, add 2% pepsin, keep warm for 3 hours, adjust the pH value to 7.5, add 2% trypsin, and keep warm for 5 hour, boiled for 10 minutes, centrifuged, and the precipitate was discarded. The supernatant was ultrafiltered through an ultrafiltration membrane with a relative molecular mass of 3KD, and the permeate was added to a DA201-C macroporous adsorption resin column, eluted with water, and discarded. Wash the liquid with water, then elute with 60% (V / V) ethanol, collect the ethanol eluate, recover the ethanol under reduced pressure and continue to concent...

Embodiment 3

[0038] Get the chromium-rich mung bean small peptide 100g that the method of Example 1 gains, press chromium-rich mung bean small peptide: corn oil: beeswax: lecithin ratio is 10:35:4:1 mixed material, through grinding 30 minutes, with gelatin, purified water , glycerin, and iron oxide black in the ratio of 100:100:40:1 to make soft capsule skin glue, control the temperature of the plastic box at 40-50°C, the temperature of the heat preservation tank at 35-45°C, and the temperature of the spray body at 30-40°C, and press it into a soft capsule. Capsules, the content of each capsule weighs 0.45g, dried in cold air at 17°C-27°C for 3-5h to finalize the shape, washed pills, dried, selected pills, packed, and prepared into finished soft capsules.

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Abstract

The invention discloses chromium-enriched mung bean small peptide having function of reducing blood sugar and a preparation method of the chromium-enriched mung bean small peptide, and belongs to the field of biological technologies. The chromium-enriched mung bean small peptide is characterized in that mung bean protein is used as a starting material, and the chromium-enriched mung bean small peptide is obtained through steps of performing chelating enzymolysis, performing ultrafiltration, performing resin column purification, performing decompressing concentration, and performing spray drying. The chromium-enriched mung bean small peptide can be used as a main raw material, other raw materials and auxiliary materials are added, and through a conventional preparation method, a series of corresponding preparations are prepared. The method for synchronously performing enzymolysis and chromium enriching is adopted, so that the chromium-enriched mung bean small peptide has the characteristics of being high in chromium enriching efficiency and high in organising rate of elements, and the chromium-enriched mung bean small peptide can notably reduce high blood sugar.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a chromium-rich mung bean small peptide with hypoglycemic effect and a preparation method thereof. Background technique [0002] Diabetes, especially type 2 diabetes, has become a global health threat. With the improvement of domestic people's living standards, changes in dietary structure and lifestyle have led to a rapid increase in diseases related to glucose and lipid metabolism disorders. Among them, the number of people with diabetes has exceeded 110 million, ranking first in the world. Diabetes-related complications, such as macrovascular disease, microvascular disease and tumors, have become the main causes of death and disability in the domestic population. The reason for the sharp increase in the number of diabetic patients in my country may be the result of the combined effects of genetic and environmental factors, involving susceptibility genes, epigenetic effects, gluc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/16A23L33/18
CPCA23L33/16A23L33/18A23V2002/00A23V2200/328A23V2250/55A23V2250/1586
Inventor 刘玉军刘国飞赵红金
Owner ANHUI BIOLOGICAL PEPTIDE IND RES INST
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