A preparation method of sea urchin-shaped gold nanoparticles and its application in tumor imaging and treatment

Abstract

The invention discloses a green preparation method of sea urchin shaped nanogold and application of the nanogold in tumor imaging and treatment. Chloroauric acid is mainly used as a gold source, a stabilizer, a reducing agent and a growth inhibitor are successively added, and the nanogold is prepared by adopting a one-step synthesis method. The method is simple, mild, green and friendly to the environment. The synthesized sea urchin shaped nanogold can serve as a contrast agent to be applied to multiple medical imaging modes such as opto-acoustic imaging (PA), positron emission computed tomography imaging (PET) and infrared thermal imaging (TI), patients can obtain multiple diagnostic effects only by needing to bear one contrast agent for dose, the dosage of contrast agent can be reduced, and the toxic and side effects are thus reduced. In addition, the material can achieve conversion of light and heat under near-infrared light irradiation of 808 nm, can absorb a large number of X rays, has higher light-heat conversion efficiency, and can be used for the preparation of a therapeutic agent for light and heat treatment (PTT), radiotherapy (RT), or combined therapy of PTT / RT of tumor cells.

Description

technical field [0001] The invention relates to a green synthesis method of sea urchin-shaped nano gold and its application in multimodal imaging and combined treatment of tumors. Background technique [0002] Malignant tumors seriously endanger human health, and the development of nanomaterial technology has brought new ideas for the diagnosis and treatment of malignant tumors. The use of nanomaterials to realize the combination of diagnosis and treatment of tumors (combination of diagnosis and treatment) has received more and more attention in recent years. The unique physicochemical properties of nanomaterials endow them with great potential to integrate imaging diagnosis and drug therapy on a single platform. Therefore, the development of imaging and therapeutic integrated preparations has become a current research hotspot. Such preparations have great potential advantages in the accurate diagnosis and effective treatment of cancer, and provide a new opportunity for "vi...

AI Technical Summary

Problems solved by technology

Taking the precious metal gold as an example, gold can be prepared in various shapes, such as gold rods, flake gold, star gold and cage gold. They have good absorption of near-infrared light, so they are widely used for photothermal properties. However, the preparation process of these gold nanoparticles with different morphologies is complicated, the preparation conditions are harsh, and the metal "melting effect" will appear under long-term laser irradiation, and the structure is unstable, which limits their application as photothermal reagents. application

[0006] A search of domestic and foreign literature and patents on multimodal imaging and combined therapy integrated nano-platforms shows that no PA / PET / TI multimodal imaging and PTT / RT combined therapy based on sea urchin-shaped gold nanoparticles have been found so far. Report on the green preparation method and application of multifunctional nanoparticles

Images