Preparation method of cassia twig and poria cocos pills

Abstract

The invention discloses a preparation method of cassia twig and poria cocos pills and belongs to the technical field of traditional Chinese medicines. By adopting the technical scheme, the preparation method comprises the following steps: crushing poria cocos into fine powder respectively; then carrying out alcohol extraction and water extraction on peach kernels and red paeony roots in sequence; or crushing cassia twigs and coxtex moutan into fine powder or extracting and concentrating to prepare concentrated water-paste pills or water-honeyed pills by adopting different blending technologies; carrying out a subsequent pill preparation technology to prepare the cassia twig and poria cocos pills. According to the preparation method of the cassia twig and poria cocos pills, a complete technical scheme is formed by powdering, concentration, blending and pelleting, so that the extract yield is improved, effective components are sufficiently extracted, the bioavailability is improved and the dissolution time limit is effectively controlled; the preparation method has the advantages of short production period, stable preparation quality, high effective component content, rapidness in disintegration, high bioavailability, small oral administration dosage, convenience for oral administration and the like, and can be applied to preparation of cassia twig and poria cocos water-paste pill and water-honeyed pill dosage forms.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicines, in particular to a preparation method of Guizhi Fuling Pills. Background technique [0002] Guizhi Fuling Pills originated from "Synopsis of the Golden Chamber" by Zhang Zhongjing in Eastern Han Dynasty. Symptom block, or amenorrhea due to blood stasis, abdominal pain during menstruation, endless lochia after delivery. [0003] Among the cinnamon twigs and poria cocos, the cinnamon twig is the king of the prescription, and its chemical composition is mainly volatile oils, and its active ingredient is cinnamic aldehyde. In addition, cinnamic acid in the ethanol extract is also one of the active ingredients of this product: Moutan bark The main chemical components are paeonol, paeonol glycoside, paeonol protoside, paeoniflorin, hydroxy paeoniflorin, etc.; the main active ingredients in Radix Paeoniae Rubra are paeoniflorin, paeoniflorin, paeonol, etc.; The ing...

AI Technical Summary

Problems solved by technology

There are certain technical defects in the production process. First, the traditional extraction method is used to extract the active ingredients in the drug incompletely, resulting in low bioavailability; second, the prescription contains both volatile and fat-soluble active ingredients and water-soluble active ingredients. ingredients, so that the prescription is easy to be lost in the process of extraction, concentration, and pellet drying, especially the active ingredient paeonol in Moutan cortex is unstable, and it will decompose and lose when the temperature is higher than 60-65°C, resulting in a decrease in its active ingredients. Affect the curative effect of the drug, and at the same time, when the pill making process is improper, it will affect the dissolution time limit and it is difficult to control

[0005] Authorized announcement number CN 102772517 B A preparation method of Guizhi Fuling pills is by preparing Guizhi Fuling pill powder, making pills, first microwave vacuum drying, coating and second microwave vacuum drying. Forming process preparation; authorized announcement numbers CN 100356942C and CN 100586425C Guizhi Fuling Soft Capsule and its preparation process specifically relate to the new drug preparation of Guizhi Fuling, which is composed of medicinal liquid oil and capsule material; but none of them solves the problem of traditional water pills and water honey pills. Stability and dissolution of active ingredients in

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