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Solid dispersion containing xanthophyll and microwave melting preparation method thereof

A solid dispersion, lutein technology, applied in the direction of active ingredients of hydroxyl compounds, devices for making medicines into special physical or taking forms, antidote, etc., can solve the oxidation and decomposition of lutein and uneven temperature, The organic solvent is not easy to remove and the heating temperature is high, so as to increase the bioavailability, solve the problem of low solubility and high heating quality.

Inactive Publication Date: 2017-11-03
广州百花香料股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing preparation method of lutein-containing solid dispersion generally adopts the solvent method or the melting method of fire heating. This melting method has high heating temperature and long time, which easily causes the oxidation and decomposition of lutein and uneven temperature. , Difficult to control temperature and other issues; solvent method needs to add organic solvent, organic solvent is not easy to remove, easy to remain, and the cost is relatively high

Method used

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  • Solid dispersion containing xanthophyll and microwave melting preparation method thereof
  • Solid dispersion containing xanthophyll and microwave melting preparation method thereof

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preparation example Construction

[0029] The present invention also relates to a microwave melting preparation method of a solid dispersion containing lutein as claimed in claim 1, which comprises the following steps:

[0030] a. Proportion the following components according to the stated parts by weight: 3-8 parts of lutein, 72-95 parts of water-soluble carrier, 0-15 parts of surfactant, 0-3 parts of plasticizer, and 0 parts of antioxidant -2 parts, grind and mix evenly by grinding method to make primary physical mixture;

[0031] b. Put the primary physical mixture in a microwave reactor, under the heating power of 200-900W, completely melt the mixture under vacuum radiation, and put the molten mixed solution at room temperature to solidify and pulverize to obtain a solid dispersion containing lutein.

[0032] The preferred heating power is 400-700W.

[0033] The invention adopts a microwave melting method to prepare solid dispersion containing lutein, which can well solve the problems of low solubility of ...

Embodiment 1

[0037] Lutein solid dispersion consists of the following raw materials in parts by weight: 8 parts of lutein, 72 parts of water-soluble carrier (40 parts of PEG2000, 40 parts of PEG8000), 15 parts of surfactant (5 parts of paloxamer 188, 5 parts part paloxamer 237, 5 parts paloxamer 338), plasticizer 3 parts (1 part 1,3 propylene glycol, 1 part mannitol, 1 part sorbitol), antioxidant 2 parts (1 part tea polyphenols, 1 part tert-butylhydroquinone), ground evenly to make a primary physical mixture. The physical mixture is placed in a microwave reactor, and the mixture is completely melted under the heating power of 200W, and the molten mixture is solidified and pulverized at room temperature to obtain a solid dispersion of lutein.

Embodiment 2

[0039]Lutein solid dispersion is composed of the following raw materials in parts by weight: 3 parts of lutein, 95 parts of water-soluble carrier (25 parts of PEG2000, 35 parts of PE4000, 35 parts of PEG6000), 0.1 part of surfactant (0.1 part of Paloza Mu 188), 0.1 part of plasticizer (0.1 part of glycerol), 2 parts of antioxidant (1 part of tocopherol, 1 part of ascorbic acid), grind evenly to make a primary physical mixture. The physical mixture is placed in a microwave reactor, and the mixture is completely melted under the heating power of 900W, and the molten mixture is solidified and pulverized at room temperature to obtain a solid dispersion of lutein.

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Abstract

The invention relates to a solid dispersion containing xanthophyll and a microwave melting preparation method thereof. The microwave melting preparation method has the following steps that 1, the xanthophyll, a carrier, a plasticizer and an additive are evenly mixed by adopting a grinding method according to a certain weight ratio; 2, the mixture is put in a microwave reactor and is subjected to vacuum radiation under the heating power of 200-900 W for complete melting, the molten mixed solution solidified and is smashed at room temperature to obtain the solid dispersion containing xanthophyll. The microwave melting preparation method does not need an organic solvent, the preparation time is short, the efficiency is high, oxidative degradation of the xanthophyll can be effectively avoided, the solubility of the finished product in water can be remarkably improved, the bioavailability of the bioavailability is effectively improved, and the commercial purpose is wider.

Description

technical field [0001] The invention belongs to the field of food and pharmaceutical preparations, in particular to a solid dispersion containing lutein and a microwave melting preparation method thereof. Background technique [0002] Lutein is an oxygen-containing carotenoid, in addition to being used as a coloring agent, it also has a variety of physiological functions, such as anti-oxidation, eliminating free radicals, anti-cancer, reducing the incidence of cardiovascular diseases and visual protection, etc. , especially in the prevention of senile cataract and age-related macular degeneration, etc., has an irreplaceable role. Lutein is widely distributed in plants such as banana, kiwi fruit, corn and marigold. The lutein used in food industry, feed industry and pharmaceutical industry is generally extracted from marigold. Due to the presence of 10 conjugated double bonds in the molecular structure, lutein crystals are very unstable, very sensitive to light, heat, and ox...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/047A61K47/10A61J3/02A61P39/06A61P35/00A61P9/00A61P27/02A61P27/12A23L33/105A23L5/44
Inventor 庄子翀钟炼军朱良
Owner 广州百花香料股份有限公司
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