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Modified xanthan gum nano-micelle preparation method

A technology of nano-micelle and nano-micelle solution, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. It can improve the drug release time, enhance the antioxidant performance, and be less prone to oxidative degradation.

Active Publication Date: 2017-11-03
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the side chain and main chain of xanthan gum form a helix and multiple helical advanced structures through hydrogen bonds, the dissolution rate of xanthan gum in water decreases, and the water solubility decreases, and some active groups are wrapped in the structure, which limits the xanthan gum. Antioxidant activity and stability

Method used

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  • Modified xanthan gum nano-micelle preparation method

Examples

Experimental program
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Embodiment 1

[0032] 1-1) Phthalic anhydride modified xanthan gum to synthesize amphiphilic modified xanthan gum polymer:

[0033]Dissolve 2g of xanthan gum in 200mL of deionized water, stir it evenly, add 0.06g of 4-dimethylaminopyridine, slowly add 20mL of acetone solution with 0.5g of phthalic anhydride to the above xanthan gum solution , stir evenly, heat up to 60°C for 12 hours, then cool to room temperature, precipitate with 3 times the volume of ethanol, filter, wash the precipitate with ethanol three times, and dry in vacuum at 60°C to constant weight to obtain phthalic anhydride modified xanthogen Glue the crude product; dissolve the crude product with deionized water, configure it into a 0.5w% solution, and move it to a dialysis bag with a molecular weight cut-off of 14000. The deionized water is the external fluid for dialysis. Change the external fluid for dialysis every 5 hours. After less than 72 hours, unreacted small molecules and catalysts were removed, and the dialysis sam...

Embodiment 2

[0039] As shown in Example 1-1), the xanthan gum aqueous solution is prepared, the same amount of catalyst is added, and 20 mL of acetone solution with 1.0 g of phthalic anhydride is slowly added dropwise to the above-mentioned xanthan gum solution, stirred evenly, and heated After reacting at 60°C for 12 hours, cool to room temperature, post-treatment as in Example 1-1), prepare modified xanthan gum nanomicelles as in Example 1-2), and prepare drug-loaded modified xanthan gum nanomicelles as in the implementation Example 1-3), the obtained modified xanthan gum nano-micelle is denoted as XP2.

Embodiment 3

[0041] As shown in Example 1-1), prepare an aqueous solution of xanthan gum, add the same amount of catalyst, slowly add 20 mL of acetone solution that is dissolved with 2.0 g of phthalic anhydride into the above-mentioned xanthan gum solution, stir evenly, and heat up After reacting at 60°C for 12 hours, cool to room temperature, post-treatment as in Example 1-1), prepare modified xanthan gum nanomicelles as in Example 1-2), and prepare drug-loaded modified xanthan gum nanomicelles as in the implementation Example 1-3), the obtained modified xanthan gum nano-micelle is denoted as XP3.

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Abstract

The invention relates to the technical field of biological and medical materials, in particular to a preparation method of injection type modified xanthan gum nano-micelle. The preparation method comprises the steps: performing esterification reaction on phthalic anhydride and xanthan gum, preparing amphipathic modified xanthan gum polymer by a one-step method and then self assembling and preparing modified xanthan nano-micelle by a selective solvent method. The xanthan gum is anhydride modified, so that biocompatibility and oxidation resistance of the xanthan gum are improved. The xanthan gum nano-micelle has a hydrophobic cavity with a benzene ring and a hydrophilic outer layer of the xanthan gum, so that circulation stability of the nano-micelle in a biological body is improved; in addition, the modified xanthan gum contains carboxylic groups, so that the nano-micelle has certain pH response; a charge effect of the nano-micelle can also be utilized to load medicine doxorubicin, so that the medicine loaded nano-micelle has a certain slow-release function. The preparation method disclosed by the invention has simple synthetic steps and is green, and the nano-micelle can be completely degraded in the body and hopefully serves as a carrier of anti-cancer drug to control release.

Description

technical field [0001] The invention relates to a preparation method of modified xanthan gum nano micelles, which belongs to the application of natural polymer materials in the field of biomedical technology. Background technique [0002] As a natural polysaccharide, xanthan gum is an exopolysaccharide secreted by Xanthomonas campestris, and is an important biopolymer. Its main chain structure is the same as that of cellulose, and its side chain terminal manna The sugar has a pyruvate group attached to it. Because the side chain and the main chain of xanthan gum form a helix and multiple helix advanced structure through hydrogen bonds, the dissolution rate of xanthan gum in water decreases, and the water solubility decreases. Some active groups are wrapped in the structure, which limits the xanthan gum. Antioxidant activity and stability. Because xanthan gum is non-toxic, harmless, and highly adaptable, it has a wide range of applications in the field of life sciences, suc...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/36A61K31/704A61P35/00
CPCA61K9/1075A61K31/704A61K47/36
Inventor 倪才华徐杰张丽萍石刚桑欣欣
Owner JIANGNAN UNIV
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