Bone targeted liposome, drugs and preparations thereof, and preparation method and application thereof

Abstract

The invention discloses a bone targeted liposome containing a compound of a structure in Formula 5, wherein n is selected from integers from 1 to 100, and the invention also discloses a bone targeted liposome drug containing the liposome and active drug molecules wrapped therein and preparations of the bone targeted liposome drug and a preparation method and application thereof. The bone targeted liposome uses pyrophosphoric acid to modify the liposome surface, has good bone affinity and good targeting, solves the problem that bonding between existing bone targeted drugs and a bone surface is insufficient, and can be targeted to various surfaces of bones: a bone absorption surface, a bone forming surface, a bone growth plate, the interior of cortical bone and a bone concave cavity, a bone targeting characteristic range is wider, and requirements for loading various drugs for treating bone diseases can be fully satisfied. The invention also discloses a tanshinol bone targeted liposome drug and application thereof in fracture healing disorders, and the drugs can promote formation of callus in an early stage, and promote transformation of the callus to normal bone in a later stage, thereby remarkably shortening fracture healing time and enhancing the mechanical property of bone after fracture healing.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and in particular relates to a bone-targeting liposome, a medicine containing the liposome, a preparation, a preparation method, and an application thereof in preparation of a medicine for treating bone disease. Background technique [0002] Bone disease is a general term for bone and joint-related diseases, mainly including osteoporosis, fracture healing disorders, arthritis, and various acute and chronic neck, shoulder, waist, and leg pains. Although there have been some corresponding drug researches for various bone diseases, and some of them have been applied clinically, due to the high hardness of bone tissue, low blood flow, poor permeability, and special physiological and biochemical processes, the treatment of bone diseases Almost all of the drugs are difficult to be effectively transported to the site of action according to the general route of administration, and the curati...

AI Technical Summary

Problems solved by technology

Whether it is autologous bone graft surgery or BMP protein intervention, there are problems such as inconvenient operation, high cost and poor safety, so it is difficult to meet the clinical needs

[0011] In view of the fact that the incidence rate of fracture healing disorder is not low and there is a lack of effective therapeutic drugs, further searching for simple, safe and effective fracture healing disorder drugs is another technical problem to be solved by the inventors of the present invention.

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