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Tripterygium glycosides nano-emulsion gel and preparation method thereof

A nanotechnology of tripterygium glycosides and polyglycosides, which is applied in the field of medicine, can solve the problems of affecting drugability and bioavailability, difficulty of tripterygium glycosides, and limitation of clinical application, so as to avoid the first-pass effect of the liver and promote transdermal Good absorption and viscosity

Active Publication Date: 2017-10-31
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical effect of Tripterygium wilfordii polyglycosides is significant, but because of the obvious "peak-valley" phenomenon in oral absorption, it is easy to cause relatively large toxic reactions, and the incidence of adverse reactions in the digestive system and genitourinary system are 35.8% and 22.8%
At the same time, because tripterygium glycosides are insoluble in water and poorly absorbed in the body, it affects the improvement of its druggability and bioavailability, which seriously limits its clinical application.

Method used

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  • Tripterygium glycosides nano-emulsion gel and preparation method thereof
  • Tripterygium glycosides nano-emulsion gel and preparation method thereof
  • Tripterygium glycosides nano-emulsion gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Weigh 0.6g tripterygium glycosides, 3.63g propylene glycol monocaprylate, 5.94g OP-10, 2.97g 1,2-propanediol, stir and mix well, slowly add 7.46g purified water to the solution, stir evenly, Prepare tripterygium glycosides nanoemulsion.

[0069] Weigh 0.3g of Carbomer 940, add an appropriate amount of purified water to submerge the poloxamer below the water surface, and place it in a refrigerator at 4°C to make it fully swell.

[0070] After 24 hours, take out the swollen carbomer, add tripterygium glycosides nanoemulsion while stirring, and stir evenly to obtain a yellow transparent tripterygium glycosides nanoemulsion gel preparation.

Embodiment 2

[0072] Weigh 0.6g tripterygium glycosides, 3.63g propylene glycol monocaprylate, 5.94gOP-10, 2.97g Tween 80, stir and mix well, slowly add 7.46g purified water to the solution, and stir evenly to obtain tripterygium Rattan polyglycoside nanoemulsion.

[0073] Weigh 0.3g of Carbomer 940, add an appropriate amount of purified water to submerge the poloxamer below the water surface, and place it in a refrigerator at 4°C to make it fully swell.

[0074] After 24 hours, take out the swollen carbomer, add tripterygium glycosides nanoemulsion while stirring, and stir evenly to obtain a yellow transparent tripterygium glycosides nanoemulsion gel preparation.

Embodiment 3

[0076] Weigh 0.6g tripterygium glycosides, 3.63g propylene glycol monocaprylate, 5.94g Tween 80, 2.97g 1,2-propanediol, stir and mix well, slowly add 7.46g purified water to the solution, stir evenly, Prepare tripterygium glycosides nanoemulsion.

[0077] Weigh 0.3g of Carbomer 940, add an appropriate amount of purified water to submerge the poloxamer below the water surface, and place it in a refrigerator at 4°C to make it fully swell.

[0078] After 24 hours, take out the swollen carbomer, add tripterygium glycosides nanoemulsion while stirring, and stir evenly to obtain a yellow transparent tripterygium glycosides nanoemulsion gel preparation.

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Abstract

The invention belongs to the technical field of a pharmaceutical preparation and specifically relates to a tripterygium glycosides nano-emulsion gel, a preparation method thereof and an application thereof. The main ingredients of the tripterygium glycosides nano-emulsion gel disclosed by the invention include raw material tripterygium glycosides, an oil phase, a surfactant, a cosurfactant, a gel matrix and deionized water. The method comprises the following steps: mixing tripterygium glycosides with the oil phase, surfactant and cosurfactant; dropwise adding the deionized water into the mixed solution; magnetically stirring, thereby acquiring the tripterygium glycosides nano-emulsion; and adding the gel matrix, thereby acquiring the tripterygium glycosides nano-emulsion gel. The invention selects an O / W type nano-emulsion as a transdermal drug delivery carrier for preparing a tripterygium glycosides nano-emulsion gel transdermal preparation and provides a novel effective drug preparation for the clinical application of tripterygium glycosides.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to tripterygium glycosides nanoemulsion gel and its preparation method and application. Background technique [0002] Tripterygium wilfordii Hook.f. is a woody vine of the genus Tripterygium wilfordii in the family Euonymus. It is bitter in nature and highly poisonous. Tripterygium wilfordii polyglycoside is the main active part of Tripterygium wilfordii, which has anti-inflammatory, analgesic, anti-tumor and immune regulation effects, and is often used clinically to treat skin inflammation, immunosuppression, and malignant tumors. The clinical effect of Tripterygium wilfordii polyglycosides is significant, but because of the obvious "peak-valley" phenomenon in oral absorption, it is easy to cause relatively large toxic reactions, and the incidence of adverse reactions in the digestive system and genitourinary system are 35.8% and 22.8%. At the same time, because tripterygium gly...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/585A61K47/10A61K47/32A61K47/14A61P17/00A61P17/06A61P19/02A61P29/00A61P37/00
CPCA61K9/0002A61K9/0014A61K9/06A61K31/585A61K47/10A61K47/14A61K47/32
Inventor 刘继勇杨盟杨帝顺顾永卫顾清唐晓萌
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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