Preparation method of eye nursing composition liposome
A technology for eye care and composition, which is applied in the field of preparation of eye care composition liposomes, can solve the problems of high irritation of vitamin A alcohol, no crow's feet at the corners of the eyes, water retention, etc., and achieve good stability and encapsulation High efficiency and excellent effect
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Embodiment example 1
[0050] A preparation method of eye care composition liposome, comprising the following steps:
[0051] 1) Weigh carnosine, fructose diphosphate sodium salt, tranexamic acid, and acetyl hydroxyproline according to a mass ratio of 5:5:6:4, and mix to obtain an eye care composition;
[0052] 2) Weigh the above-mentioned eye care composition and ethanol according to a mass ratio of 1:10, mix and heat the two to 70°C, stir with an IKA stirrer at 500 rpm until completely dissolved, and obtain an eye care composition dispersion;
[0053] 3) Weigh cetearyl glucoside (TEGO CARE CG90, Evonik, Germany), potassium cetyl phosphate (AMPHISOL K, DSM, Netherlands) according to the mass ratio of 5: 1: 30, deionized water, three After mixing, heat to 80°C, and stir at a low speed of 500 rpm with an IKA stirrer until completely dissolved to obtain a surfactant composition solution;
[0054] 4) Weigh 25% of the eye care composition dispersion obtained in step 2, 10% of the surfactant composition...
Embodiment example 2
[0057] A preparation method of eye care composition liposome, comprising the following steps:
[0058] 1) Weigh carnosine, fructose diphosphate sodium salt, tranexamic acid, and acetyl hydroxyproline according to a mass ratio of 5:5:6:4, and mix to obtain an eye care composition;
[0059] 2) Weigh the above-mentioned eye care composition, propylene glycol and glycerin mixture (propylene glycol: glycerol is 1:1) according to the mass ratio of 1:10, mix and heat the three to 80°C, stir with an IKA stirrer at 500rpm until completely dissolved, and obtain eye care composition dispersion;
[0060] 3) Weigh cetearyl glucoside (TEGO CARE CG90, Evonik, Germany), potassium cetyl phosphate (AMPHISOL K, DSM, Netherlands) according to the mass ratio of 5: 1: 30, deionized water, three After mixing, heat to 80°C, and stir at a low speed of 500 rpm with an IKA stirrer until completely dissolved to obtain a surfactant composition solution;
[0061] 4) Weigh 25% of the eye care composition ...
Embodiment example 3
[0064] A preparation method of eye care composition liposome, comprising the following steps:
[0065] 1) Weigh carnosine, fructose diphosphate sodium salt, tranexamic acid, and acetyl hydroxyproline according to a mass ratio of 5:5:6:4, and mix to obtain an eye care composition;
[0066] 2) Weigh the above-mentioned eye care composition and butanediol according to a mass ratio of 1:10, mix and heat the two to 75°C, stir with an IKA stirrer at 500rpm until completely dissolved, and obtain an eye care composition dispersion;
[0067] 3) Weigh cetearyl glucoside (TEGO CARE CG90, Evonik, Germany), potassium cetyl phosphate (AMPHISOL K, DSM, Netherlands) according to the mass ratio of 5: 1: 30, deionized water, three After mixing, heat to 75°C, and stir with an IKA stirrer at a low speed of 500 rpm until completely dissolved to obtain a surfactant composition solution;
[0068] 4) Weigh 25% of the eye care composition dispersion obtained in step 2, 10% of the surfactant compositi...
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