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Temperature-sensitive tri-block polymer, reduction and ultrasonic-sensitive core-shell structural microgel with same and application of reduction and ultrasonic-sensitive core-shell structural microgel

A core-shell structure and sensitive technology, applied in the field of physical chemistry, can solve problems such as difficult drug release

Inactive Publication Date: 2017-10-17
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] A single stimuli-responsive polymer micelle is difficult to achieve more precise drug release in space and time

Method used

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  • Temperature-sensitive tri-block polymer, reduction and ultrasonic-sensitive core-shell structural microgel with same and application of reduction and ultrasonic-sensitive core-shell structural microgel
  • Temperature-sensitive tri-block polymer, reduction and ultrasonic-sensitive core-shell structural microgel with same and application of reduction and ultrasonic-sensitive core-shell structural microgel
  • Temperature-sensitive tri-block polymer, reduction and ultrasonic-sensitive core-shell structural microgel with same and application of reduction and ultrasonic-sensitive core-shell structural microgel

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Embodiment Construction

[0032] The inventors designed a temperature-sensitive tri-block polymer with the structure of PEI m -b-PNIPAM n -b-PEI m , wherein the degree of polymerization n: 20, 50, 100, 150, 300, PEI molecular weight m: 600, 1800, 10000.

[0033] The temperature-sensitive tri-block polymer provided by the invention has amphiphilicity, with hydrophilic branched PEI at both ends and temperature-sensitive PNIPAM in the middle.

[0034] The present invention provides the preparation method of this triblock polymer.

[0035] Triblock polymer of the present invention, it is made by following method:

[0036] 1) In a Schlenk bottle, dissolve monomer NIPAM, chain transfer agent bis(carboxymethyl)trithiocarbonate, and initiator AIBN in 1,4-dioxane at a molar ratio of n:10:1 , carry out ATRP polymerization, and react the system at 60-70°C for 6-8h to obtain HOOC-PNIPAM n -COOH. (n:20, 50, 100, 150, 300)

[0037] 2) The HOOC-PNIPAM described in step 1) n -COOH was rotary evaporated at 40-5...

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Abstract

The invention belongs to the field of physical chemistry, and provides a temperature-sensitive tri-block polymer, reduction and ultrasonic-sensitive core-shell structural microgel with the same and application of the reduction and ultrasonic-sensitive core-shell structural microgel. The structure of the temperature-sensitive tri-block polymer is PEI<m>-b-PNIPAM<n>-b-PEI<m>, the temperature-sensitive tri-block polymer is amphiphilic at the lower critical solution temperatures (LCST) and can be subjected to self-assembly in aqueous solution to obtain micelle solution with uniform particle sizes in stable states, PNIPAM<n> is used as a core of the micelle solution, and PEI is used as a shell of the micelle solution. Addition can be carried out on micelle and cross-linking agents BAC<y> to obtain reduction-sensitive gel shells, and disulfide bonds on the shells can be selectively cracked by reducing reagents such as GSH, TCEP and DTT. The temperature-sensitive tri-block polymer, the reduction and ultrasonic-sensitive core-shell structural microgel and the application have the advantages that halothane molecules with gas-liquid phase change properties can be loaded, accordingly the core-shell structural microgel with ultrasonic response can be obtained, and the purpose of target medicine administration can be achieved.

Description

technical field [0001] The invention belongs to the field of physical chemistry, and in particular relates to a synthesized temperature sensitive triblock polymer, a reduction and ultrasonic sensitive core-shell microgel containing the triblock polymer and its application in the preparation of the core-shell microgel application. Background technique [0002] Polymer micelle is a new type of pharmaceutical preparation, which is formed by the self-assembly of amphiphilic di-block or tri-block polymers. It has the advantages of simple preparation, high drug loading and controlled drug release. It is a very promising drug carrier. Generally, polymer micelles form core-shell nanospheres, the inner core is hydrophobic and can accommodate hydrophobic drugs; the outer shell is hydrophilic to ensure its stability and solubility in aqueous solution. It is also possible to chemically modify the shell to give it a specific function. [0003] A single stimuli-responsive polymer micel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/02A61K9/107A61K47/34A61K9/06
CPCA61K9/0009A61K9/06A61K9/1075A61K47/34C08G81/024
Inventor 徐首红雷彬沈能为王义洲刘洪来
Owner EAST CHINA UNIV OF SCI & TECH
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