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Hemostatic antibacterial material and preparation method thereof

A hemostatic antibacterial, extract technology, applied in the field of hemostatic antibacterial materials and their preparation, to achieve good biocompatibility and good antibacterial effect

Inactive Publication Date: 2017-10-10
苏州凌科特新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Death due to excessive bleeding is a common phenomenon. With the rapid development of science and technology, research on medical dressings has also made great progress. The development of current hemostatic materials is still immature, and clinical needs also put forward higher requirements for the research and development of hemostatic materials. requirements, not only require better hemostatic performance, but also strong antibacterial properties, high degradability, and air and water permeability must meet a certain standard, which has also become the motivation for the development of new hemostatic materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A hemostatic and antibacterial material, prepared from the following ingredients in parts by weight: 1 part of cornstarch, 2 parts of Erythrophyllum var. 1 part of oxidized cellulose, 1 part of gelatin, 1 part of silk fibroin, 0.2 part of psoralen, 1 part of viola, 0.2 part of polyphosphoric acid, 0.2 part of glycerol, 0.1 part of polyethylene glycol, 50 parts of methanol, 60 parts of distilled water.

[0019] The preparation method of above-mentioned hemostatic antibacterial material is:

[0020] Step 1: Mix Echinocarpus and Viola, freeze-dry and pulverize, add methanol, perform ultrasonic extraction for 40 minutes, and then conduct vacuum distillation to remove the solvent;

[0021] Step 2: Add corn starch, carboxymethyl chitosan, tsubaki bark extract, black olive extract, oxidized cellulose, gelatin, silk fibroin, psoralen and distilled water, heat to 60°C and stir for 10 minutes;

[0022] Step 3: Add polyphosphoric acid, glycerol and polyethylene glycol, and stir ...

Embodiment 2

[0026] A hemostatic and antibacterial material, prepared from the following ingredients in parts by weight: 1.2 parts of cornstarch, 3 parts of Pteridocarpus var. 1.5 parts of oxidized cellulose, 1.2 parts of gelatin, 1.5 parts of silk fibroin, 0.25 parts of psoralen, 1.5 parts of viola, 0.3 parts of polyphosphoric acid, 0.26 parts of glycerol, 0.15 parts of polyethylene glycol, 60 parts of methanol, 70 parts of distilled water.

[0027] The preparation method of above-mentioned hemostatic antibacterial material is:

[0028] Step 1: Mix the fern and Viola, freeze-dry and pulverize, add methanol, perform ultrasonic extraction for 45 minutes, and then carry out vacuum distillation to remove the solvent;

[0029] Step 2: Add cornstarch, carboxymethyl chitosan, Chinese toon bark extract, black olive extract, oxidized cellulose, gelatin, silk fibroin, psoralen and distilled water, heat to 65°C and stir for 15 minutes;

[0030] Step 3: Add polyphosphoric acid, glycerol and polyeth...

Embodiment 3

[0034] A hemostatic and antibacterial material, prepared from the following ingredients in parts by weight: 1.5 parts of cornstarch, 3.5 parts of Pteridocarpus var. 2 parts of oxidized cellulose, 1.5 parts of gelatin, 2 parts of silk fibroin, 0.3 parts of psoralen, 2 parts of viola, 0.35 parts of polyphosphoric acid, 0.35 parts of glycerol, 0.2 parts of polyethylene glycol, 65 parts of methanol, 75 parts of distilled water.

[0035] The preparation method of above-mentioned hemostatic antibacterial material is:

[0036] Step 1: Mix Echinocarpus and Viola, freeze-dry and pulverize, add methanol, carry out ultrasonic extraction for 50 minutes, and then carry out vacuum distillation to remove the solvent;

[0037] Step 2: Add corn starch, carboxymethyl chitosan, tsubaki bark extract, black olive extract, oxidized cellulose, gelatin, silk fibroin, psoralen and distilled water, heat to 65°C and stir for 20 minutes;

[0038] Step 3: Add polyphosphoric acid, glycerol and polyethyle...

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Abstract

The invention provides a hemostatic antibacterial material and a preparation method thereof. The preparation method comprises the following steps: mixing lindsaea orbiculata and herba violae, performing freeze-drying, and grinding; adding methanol, performing ultrasonic extraction, and removing solvent by reduced pressure distillation; adding corn starch, carboxymethyl chitosan, radix paeoniae alba extract, canarium pimela extract, oxidized cellulose, gelatin, silk fibroin, psoralen and distilled water, and mixing; heating to 60-70 DEG C, and stirring; adding polyphosphoric acid, glycerol and polyethylene glycol, stirring for 10-20 minutes at a rotating speed of 600-900r / min, and standing for 20-30 minutes; and pre-freezing at negative 20 DEG C for 1-2 hours, and performing freeze-drying for 3-4 hours. The hemostatic antibacterial material has excellent water absorbability and high expansion rate, can be used for sufficiently compressing a wound, covering the wound surface and sealing the hemorrhagic spot to achieve the aim of stopping bleeding, has small infected probability, and has good biocompatibility and excellent antibacterial property.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a hemostatic and antibacterial material and a preparation method thereof. Background technique [0002] Bleeding is one of the most common problems in surgery and trauma, and effective hemostatic methods and excellent hemostatic materials are particularly critical. Death due to excessive bleeding is a common phenomenon. With the rapid development of science and technology, research on medical dressings has also made great progress. The development of current hemostatic materials is still immature, and clinical needs also put forward higher requirements for the research and development of hemostatic materials. Not only require good hemostatic performance, but also strong antibacterial properties, high degradability, and air and water permeability to meet certain standards. This has also become the motivation for the development of new hemostatic materials. Therefore, it is imp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/08A61L24/04A61L24/00
Inventor 金可心
Owner 苏州凌科特新材料有限公司
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