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Compound multilayer medical dressing of aquatic biological source crosslinking collagen

A technology of collagen and collagen sponge, which is applied in the field of cross-linked collagen composite multi-layer medical dressings from aquatic biological sources, can solve the problems of wounds being susceptible to microbial infection, weak resistance to degradation, and poor mechanical strength of natural collagen dressings, etc. Achieve excellent hemostatic effect, resist bacterial invasion, and improve the effect of comprehensive utilization

Active Publication Date: 2017-10-10
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of aquatic biological source cross-linked collagen composite multi-layer medical dressing, so as to solve the problems of poor mechanical strength of natural collagen dressing, weak anti-degradation ability, and wound susceptibility to microbial infection

Method used

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  • Compound multilayer medical dressing of aquatic biological source crosslinking collagen
  • Compound multilayer medical dressing of aquatic biological source crosslinking collagen
  • Compound multilayer medical dressing of aquatic biological source crosslinking collagen

Examples

Experimental program
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Effect test

Embodiment 1

[0038] The preparation method of aquatic biological source cross-linked collagen composite multi-layer medical dressing, the steps are as follows:

[0039] (1) Preparation of high-purity and high-activity medical collagen: scrape off scales, residual meat and fat from tilapia skin with a blade, wash in cold water, and cut into 0.5–1cm with a slicer 2of small pieces. The fish skin is treated with ultra-high pressure to increase the extraction rate of collagen, the pressure is 200MPa, and the treatment time is 5min. Soak the fish skin in 2% Triton X-100 phosphate buffer, shake on a shaker for 48h, 100rpm, 4°C, shake and rinse in distilled water, then soak the fish skin in 1% SDS phosphate buffer place on a shaker for 48 hours at 100 rpm at 4°C, shake and rinse in distilled water, and repeat the above steps 3 times to remove cells in the tissue. Add 0.1M NaOH solution (1:20, w / v) and soak for 24 hours to remove non-collagen components and pigments, and wash with distilled water...

Embodiment 2

[0057] The preparation method of aquatic biological source cross-linked collagen composite multi-layer medical dressing, the steps are as follows:

[0058] (1) Preparation of high-purity and high-activity medical collagen: Scrape off scales, residual meat and fat from cod skin with a blade, wash in cold water, and cut into 0.5–1cm with a slicer 2 of small pieces. The fish skin is treated with ultra-high pressure to increase the extraction rate of collagen, the pressure is 150MPa, and the treatment time is 10min. Soak the fish skin in 1% Triton X-100 phosphate buffer, shake on a shaker for 48h, 120rpm, 4°C, shake and rinse in distilled water, then soak the fish skin in 1% SDS phosphate buffer placed on a shaker for 48 hours at 120 rpm at 4°C, rinsed with shaking in distilled water, and repeated the above steps 3 times to remove cells in the tissue. Add 0.1M NaOH solution (1:20, w / v) and soak for 24 hours to remove non-collagen components and pigments, and wash with distilled ...

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Abstract

The invention discloses an aquatic biological source medical collagen with high purity and activity, and is capable of solving the problems of a natural collagen dressing that the mechanical strength is bad, the degradation resistance ability is weak and the wound is easily infected by microorganisms. An acid extraction method and a method of removing telopeptide by pepsase are used for extracting the collagen, the extraction ratio is improved by the ultrahigh pressure treatment and a tissue mashing method, and through a series of purification operations, such as decellularization, protein elimination, degreasing, repeated salting out, dialysis, degerming, decoloration and heat source removal, the medical collagen with the high purity and activity is prepared. A netlike collagen sponge with uniform pores is prepared by a vacuum freeze-drying technology, and the collagen sponge is modified by a physical crosslinking and chemical crosslinking mode so as to prepare the inner layer, and is compounded with a chitosan outer layer film and a medical non-woven fabric base cloth layer, finally a compound multilayer medical dressing finished product is obtained by Co-60 sterilization.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a composite multi-layer medical dressing of aquatic biological source cross-linked collagen. Background technique [0002] Collagen is a natural degradable biomacromolecule with a wide range of sources, low immunogenicity and good biocompatibility. It has excellent hemostatic properties, and it also has a good hemostatic effect on patients with coagulation dysfunction, and can promote Tissue regeneration and repair can promote wound healing. Years of clinical practice have shown that traditional physical, chemical, and mechanical hemostasis methods have certain limitations and adverse reactions, and medical dressings of natural polymer materials such as collagen are an effective surgical hemostasis method. Collagen can be applied to hemostasis of various solid organs, body surface and bone tissue, vascular tissue and connective tissue. IMS Corporation of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/10A61L15/42A61L15/32A61L15/28A61L15/46A61L15/44A61L15/24C12P21/02C07K1/34C08J9/28C08J7/12C08J7/00C08L89/00
CPCA61L15/24A61L15/28A61L15/325A61L15/425A61L15/44A61L15/46A61L24/0036A61L24/102A61L2300/232A61L2300/252A61L2300/404A61L2300/412C07K14/78C08J7/08C08J7/12C08J7/123C08J9/28C08J2201/0484C08J2389/00C12P21/02C08L5/08C08L33/08
Inventor 李八方侯虎孙蕾蕾张朝辉赵雪
Owner OCEAN UNIV OF CHINA
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