New synthesis method of brivaracetam

Abstract

The invention provides a synthesis method of brivaracetam. The method adopts cheap and easily available pentanoic acid or valeryl halide as an initial raw material, and provides a brand new synthesis route of a brivaracetam medicine, and the whole reaction route has a high total yield. The method has the advantages of high productivity, low cost, and suitableness for large-scale industrial production.

Description

technical field [0001] The invention relates to a method for synthesizing buvaracetam, which belongs to the field of drug synthesis. Background technique [0002] Brivaracetam (brivaracetam) chemical name is (2S)-2-[(4R)-2-oxo-4-propylpyrrolidin-1-yl]butanamide) is the third generation developed by Belgium UCB Antiepileptic drugs, which are structural derivatives of levetiracetam. [0003] Its published three synthesis patents are as follows: [0004] [0005] In the synthesis method mentioned in the patent, the final product needs to pass through the preparative column to separate the isomers, which has high cost and low production capacity. [0006] [0007] In the synthesis method mentioned in the patent, the two steps of the final product and the intermediate need to separate the isomers through a preparative column, which has high cost and low production capacity. [0008] [0009] The synthesis method mentioned in this patent is cumbersome and needs to be c...

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Problems solved by technology

[0009] The synthesis method mentioned in the patent is cumbersome and needs to be catalyzed by precious metals. The final product needs to be separated by column separation of isomers. The cost is high, the yield is low, and the production capacity is low. It is not suitable for large-scale industrial production.

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