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A rubidium-containing bone cement and its preparation method and application

A technology of bone cement and rubidium salt, applied in medical science, tissue regeneration, prosthesis, etc., can solve problems affecting stability and mechanical properties, interface microcracks, high elastic modulus, etc., achieve good setting time, good plasticity, The effect of accelerated release

Active Publication Date: 2019-03-29
广州光鼎科技集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, polymethyl methacrylate (PMMA) bone cement is mainly used in surgery, but studies have found that PMMA bone cement has many defects such as high elastic modulus, rapid heat release during polymerization, and non-absorption. 3-7% volume shrinkage, resulting in micro-cracks at the interface, which affects stability and mechanical properties

Method used

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  • A rubidium-containing bone cement and its preparation method and application
  • A rubidium-containing bone cement and its preparation method and application
  • A rubidium-containing bone cement and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0039] The preparation method of the rubidium-containing bone cement described in the present embodiment comprises the following steps:

[0040] Put the ball-milled and sieved bone cement powder into the agate mortar for grinding again. According to the mass ratio of rubidium salt solution to calcium aluminate is 0.7:1, add 0mol / L rubidium salt solution (ultra-pure deionized water), and stir thoroughly After mixing, put it into a clean mold, put the mold in a 100% water bath environment with a constant temperature of 37 degrees, put the bone cement cylinder in a constant temperature box at 37 degrees Celsius, and let it stand for 1-21 days before demoulding to obtain the bone cement. Restoration materials.

Embodiment 2

[0042] The preparation method of bone cement described in the present embodiment comprises the steps:

[0043] The bone cement powder that had been ball-milled and sieved was put into an agate mortar for grinding again. According to the mass ratio of rubidium salt solution to calcium aluminate at 0.7:1, 0.01mol / L rubidium salt solution (ultra-pure deionized water) was added to fully After stirring and mixing, put it into a clean mold, put the mold in a 100% water bath environment at a constant temperature of 37°C, and place the bone cement cylinder in a constant temperature box at 37°C. After standing for 1-21 days, the bone cement will be removed from the mold. Cement repair material.

Embodiment 3

[0045] The preparation method of bone cement described in the present embodiment comprises the steps:

[0046] The bone cement powder that had been ball-milled and sieved was put into an agate mortar for grinding again. According to the mass ratio of rubidium salt solution to calcium aluminate at 0.7:1, 0.05mol / L rubidium salt solution (ultra-pure deionized water) was added to fully After stirring and mixing, put it into a clean mold, put the mold in a 100% water bath environment at a constant temperature of 37°C, and place the bone cement cylinder in a constant temperature box at 37°C. After standing for 1-21 days, the bone cement will be removed from the mold. Cement repair material.

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Abstract

The invention belongs to the field of medical materials for bone damage repair and specifically relates to rubidium-containing bone cement and a preparation method and application thereof. The rubidium-containing bone cement disclosed by the invention is prepared from a rubidium salt solution and calcium aluminate, wherein a concentration of rubidium salt in the rubidium salt solution is 0.01 to 1 mol / L. The rubidium-containing bone cement disclosed by the invention has the advantages of short setting time, low setting temperature, good plasticity and biological compatibility and suitability for plastic repair in the fields of orthopedics, cerebral surgery, dentistry, cranium and the like.

Description

technical field [0001] The invention belongs to the field of medical materials for repairing bone damage, and in particular relates to a bone cement and its preparation method and application. Background technique [0002] Bone cement is a medical material used in orthopedic surgery. It has such a popular name because of some of its physical properties and its appearance and properties after solidification are similar to white cement for construction and decoration. In fact, its correct name is bone cement, which is mainly used for artificial joint replacement surgery and artificial prosthesis fixation. Bone defect cavity filling is irreplaceable, and can be divided into organic and inorganic according to chemical composition. Organic bone cement is mainly acrylic polymer, and inorganic bone cement is mainly calcium phosphate. In recent years, many new inorganic bone cements have been continuously developed, such as calcium silicate bone cement, calcium aluminate bone cemen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/56A61L27/02
CPCA61L27/025A61L27/50A61L27/56A61L2430/02
Inventor 刘咏和祥谭彦妮甘子旸武东
Owner 广州光鼎科技集团有限公司
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