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A real-time controllable micro-droplet arraying device and method based on lithium niobate sandwich structure chip

A micro-droplet and chip technology, applied in chemical instruments and methods, laboratory equipment, laboratory containers, etc., can solve the problems that the array cannot be formed at one time, the structure of the chip is complicated, and the arraying process cannot be controlled in real time.

Inactive Publication Date: 2020-07-07
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are many shortcomings in the micro-droplet arraying method reported so far, such as: high device cost, complex chip structure; cannot form an array composed of micro-droplets with equal volume at one time; arrayed micro-droplets cannot be merged and cannot be transported. Operation; the arraying process cannot be controlled in real time, etc.

Method used

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  • A real-time controllable micro-droplet arraying device and method based on lithium niobate sandwich structure chip
  • A real-time controllable micro-droplet arraying device and method based on lithium niobate sandwich structure chip
  • A real-time controllable micro-droplet arraying device and method based on lithium niobate sandwich structure chip

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Experimental program
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Effect test

Embodiment 1

[0027] Using a 532nm laser, the laser power is 7.9mW, the focal length of the lens (1) is 15mm, and the focal length of the lens (2) is 250mm, the lithium niobate sandwich structure chip is selected from the lithium niobate wafer + C face -C face, and the focusing objective lens is enlarged The multiplier is 10 times. The micro-droplets with a volume of 0.407nL to be arrayed are introduced into the lithium niobate sandwich structure chip. The expanded laser beam passes through the mask with four centrally symmetrical holes. The transparent micro-movement chip translation stage moves the interlayer droplet so that the droplet is located in the center of the square formed by the four focused laser spots, and the volume of the small droplet obtained after arraying is 101.75pL.

Embodiment 2

[0029] Use a 405nm laser, the laser power is 8.1mW, the focal length of the lens (1) is 15mm, and the focal length of the lens (2) is 250mm. The lithium niobate sandwich structure chip is made of a lithium niobate chip + a piece of quartz on the C surface, and the focusing objective lens is enlarged The multiple is 10 times, and the micro-droplets with a volume of 0.308nL to be arrayed are introduced into the lithium niobate sandwich structure chip, and the expanded laser beam passes through the mask with four centrally symmetrical holes, forming a four-dimensional A spot array composed of four laser spots, through the comprehensive adjustment of the transparent micro-movement chip translation stage to move the interlayer droplets, makes the droplets located in the center of the square formed by the four focused laser spots, and the volume of the small droplets obtained after arraying is 77pL.

Embodiment 3

[0031] Using a 532nm laser, the laser power is 4.5mW, the focal length of the lens (1) is 15mm, and the focal length of the lens (2) is 250mm, the lithium niobate sandwich structure chip is selected from the lithium niobate wafer + C face -C face, and the focusing objective lens is enlarged The multiple is 10 times, and the micro-droplets with a volume of 0.348nL to be arrayed are introduced into the lithium niobate sandwich structure chip, and the expanded laser beam passes through the mask with four centrally symmetrical holes, forming a four-dimensional A spot array composed of four laser spots, through the comprehensive adjustment of the transparent micro-movement chip translation platform to move the interlayer droplets, makes the droplets located in the center of the square formed by the four focused laser spots, and the volume of the small droplets obtained after arraying is 87pL.

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Abstract

The invention discloses a real-time controllable microdrop arraying device and a method based on a lithium niobate sandwich structure chip. The device comprises a laser device 1, a diaphragm 2, a spatial filter 3, a first lens 4, a second lens 5, a mask 6, a beam splitter 7, a first CCD (Charge Coupled Device) camera 8, a computer 9, a background light source 10, the lithium niobate sandwich structure chip 11, a transparent microchip translation table 12, an objective lens 13, a semi-transparent and semi-reflective mirror 14, an optical filter 15 and a second CCD camera 16. The device consists of a microdrop arraying light path, a real-time observation light path and a light intensity detection light path; microdrop arraying is realized by utilizing a photovoltaic effect generated by irradiating the lithium niobate sandwich structure chip by laser; arrayed microdrops can be merged and transported; and a process can be observed in real time. A technology has an important application prospect in the fields of biological analysis and detection, chemical reaction, medicine research and development and the like.

Description

technical field [0001] The invention relates to a micro-droplet manipulation technology, in particular to a real-time controllable micro-droplet arraying device and method based on a lithium niobate sandwich structure chip. Background technique [0002] With the rapid development of microfluidic chips, micro-droplet manipulation has become a research hotspot in this field. Micro-droplet manipulation technology is mainly used in the analysis and detection of micro-sample in biological, chemical, pharmaceutical and other processes. It mainly involves the transportation, mixing and separation of micro-reagents. It is of great significance to the development of fields such as biomedicine, drug diagnosis, food hygiene, environmental monitoring and molecular biology. [0003] In 2006, Utkan Demirci (Acoustic Picoliter Droplets for Emerging Applications in Semiconductor Industry and Biotechnology, Journal of Microelectromechanical Systems, 15, 957-966 (2006)) achieved micro-drople...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCG01N1/28
Inventor 阎文博李菲菲樊博麟李少北王旭亮梁超任满意陈洪建
Owner HEBEI UNIV OF TECH
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