Preparation method of nanoparticles of amphoteric ionized dendrimer inclusion gold

A dendrimer and amine dendrimer technology, applied in the field of catalyst preparation, can solve the problems of reducing the long-term stability of nanoparticles, reducing the catalytic efficiency of gold nanoparticles, etc., achieving excellent stability, good reproducibility, The effect of mild reaction conditions

Active Publication Date: 2017-08-22
YANSHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This layer of PEG will bring obvious mass transfer resistance to the modified product, thereby reducing the catalytic efficiency of the gold nanoparticles inside the dendrimers
In addition, PEG will be oxidized in an oxidizing environment for a long time, which will reduce the long-term stability of the nanoparticles it stabilizes.

Method used

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  • Preparation method of nanoparticles of amphoteric ionized dendrimer inclusion gold
  • Preparation method of nanoparticles of amphoteric ionized dendrimer inclusion gold
  • Preparation method of nanoparticles of amphoteric ionized dendrimer inclusion gold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Dissolve 16mg of fifth-generation polyamidoamine dendrimers (G5PAMAM) in 4mL of dimethyl sulfoxide, then add 13.8mg of maleic anhydride to dimethyl sulfoxide, react for 24 hours, select molecular weight cut-off ( MWCO)=14000 cellulose dialysis bag dialysis reaction mixture, to remove impurity, obtain G5M;

[0027] (2) Dissolve 2.87mg of G5M in 1mL of water, and then add 13.5mg of mercaptoethylamine to the water. After 24 hours of reaction, the mixture is dialyzed against water with a cellulose dialysis membrane (MWCO=14000) to remove impurities to obtain G5MC;

[0028] (3) Dissolve 0.533mg of G5MC in 1mL of water, then add 286mg of chloroauric acid aqueous solution with a concentration of 2mM to the water, after stirring for 20 minutes, add 126.5mg of sodium borohydride solution to the above solution, the sodium borohydride solution It is a mixed solution in which 1 mg of sodium borohydride is added to 1 mL of 0.3 M sodium hydroxide solution, and the pH of the mixed...

Embodiment 2

[0042] (1) Dissolve 1.6mg of fifth-generation polyamidoamine dendrimers (G5PAMAM) in 1mL of dimethyl sulfoxide, then add 0.754mg of maleic anhydride to dimethyl sulfoxide, react for 8 hours, select the molecular weight cut-off (MWCO)=14000 cellulose dialysis bag dialysis reaction mixture, to remove impurity, obtain G5M;

[0043] (2) Dissolve 0.52 mg of G5M in 1 mL of water, then add 0.136 mg of mercaptoethylamine to the water, react for 8 hours, and dialyze the mixture against water with a cellulose dialysis membrane (MWCO=14000) to remove impurities to obtain G5MC;

[0044] (3) 0.154mg of G5MC was dissolved in 1mL water, and then adding 61mg concentration of 1mM chloroauric acid aqueous solution in water, after stirring for 10 minutes, 4.5mg of sodium borohydride was added to the above solution, and the sodium borohydride was prepared according to Add a mixed solution of 1 mg sodium borohydride to 1 mL of 0.1 M sodium hydroxide solution, adjust the pH of the mixed solution to...

Embodiment 3

[0046] (1) Dissolve 41.2mg of the fifth-generation polyamidoamine dendrimer (G5PAMAM) in 1mL of dimethyl sulfoxide, then add 58.937mg of maleic anhydride to the dimethyl sulfoxide, react for 24 hours, select the molecular weight cut-off (MWCO)=14000 cellulose dialysis bag dialysis reaction mixture, to remove impurity, obtain G5M;

[0047] (2) Dissolve 1.83mg of G5M in 1mL of water, and then add 5.802mg of mercaptoethylamine to the water. After 24 hours of reaction, the mixture is dialyzed against water with a cellulose dialysis membrane (MWCO=14000) to remove impurities to obtain G5MC;

[0048] (3) 1.077 mg of G5MC was dissolved in 1 mL of water, and then 495 mg of chloroauric acid aqueous solution of 6 mM was added to the water. After stirring for 25 minutes, 1335.2 mg of sodium borohydride was added to the solution, and the sodium borohydride was prepared according to Add a mixed solution of 1 mg of sodium borohydride to 1 mL of 0.2 M sodium hydroxide solution, adjust the pH...

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Abstract

The invention provides a preparation method of nanoparticles of amphoteric ionized dendrimer inclusion gold. The preparation method mainly comprises the following steps: adding dimethyl sulfoxide into a fifth generation polyamide-amine dendrimer (G5 PAMAM); adding maleic anhydride to obtain fifth generation polyamide-amine dendrimer-maleic anhydride (G5M); then, adding mercaptoethylamine into a G5M water solution to obtain fifth generation polyamide-amine dendrimer-maleic anhydride-mercaptoethylamine (G5MC); adding a chloroauric acid water solution into a G5MC water solution; after stirring for 10min to 70min, adding sodium borohydride and adjusting the pH (Potential of Hydrogen) of a mixed solution to be neutral by utilizing 1M hydrochloric acid, so as to obtain the nanoparticles of the amphoteric ionized dendrimer inclusion gold (Au-G5MC). The preparation method has moderate preparation conditions and is simple to operate; a reaction process is easy to control and the stability of the nanoparticles is effectively protected.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a preparation method of a catalyst. Background technique [0002] 1-10nm gold nanoparticles have unique optical and electrical properties. These unique properties make it widely used in catalysis and nanomedicine. However, gold nanoparticles with high specific surface area are prone to agglomeration. Therefore, researchers have proposed various methods for preparing highly stable and dispersible gold nanoparticles. Crooks and colleagues first successfully prepared monodisperse copper nanoparticles using polyamide-amine dendrimer (PAMAM) templates with a unique three-dimensional structure. Furthermore, the solubility and functionality of dendrimer-wrapped AuNPs depend on the functional groups on their surface. The cytotoxicity of PAMAM-coated gold nanoparticles was positively correlated with its concentration. PAMAM is also able to induce fibrinogen ag...

Claims

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Application Information

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IPC IPC(8): B01J31/06B01J23/52B01J35/00C08F283/00C08F222/06C08F8/34
CPCC08F8/34C08F283/00B01J23/52B01J31/064C08F2800/10B01J35/393C08F222/06
Inventor 王龙刚
Owner YANSHAN UNIV
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