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Oral fast-dissolving film of xanthophylls-loaded albumin nanoparticle and preparation method thereof

A technology of albumin nanoparticles and oral instant film, which is applied in protein food processing, protein food ingredients, pharmaceutical formulations, etc., can solve the problems of poor suspension stability, uncomfortable swallowing, drug aggregation and other problems, and achieve the goal of taking Convenience, Enhanced Bioavailability, Compliant Effect

Inactive Publication Date: 2017-08-22
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the suspension has poor stability and is prone to drug aggregation
and still not suitable for patients with swallowing difficulties

Method used

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  • Oral fast-dissolving film of xanthophylls-loaded albumin nanoparticle and preparation method thereof
  • Oral fast-dissolving film of xanthophylls-loaded albumin nanoparticle and preparation method thereof
  • Oral fast-dissolving film of xanthophylls-loaded albumin nanoparticle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Swell 200 mg sodium carboxymethylcellulose in 4 mL of water overnight, stir to disperse evenly, add 100 mg of propylene glycol and 110 mg of sorbitol, add water to 10 mL and stir evenly to obtain a film-forming solution. After standing to defoam, cast in the gel template (6 × 6 cm 2 ), dried and cut into 2 × 2 cm 2 size, namely sodium carboxymethyl cellulose as a film-forming material oral cavity instant film.

[0057] The measured oral instant film is recorded as sample 1, and the specific parameters are shown in Table 1.

Embodiment 2

[0059] Swell 200 mg of HPMC 4000 in 4 mL of water overnight, stir to disperse evenly, add 100 mg of propylene glycol and 110 mg of sorbitol, add water to 10 mL and stir evenly to obtain a film-forming solution. After standing to defoam, cast in the gel template (6 × 6 cm 2 ), dried and cut into 2 × 2 cm 2 Size, that is HPMC 4000 as a film-forming material oral instant film.

[0060] The measured oral instant film is recorded as sample 2, and the specific parameters are shown in Table 1.

Embodiment 3

[0062] Swell 200 mg of polyvinylpyrrolidone in 4 mL of water overnight, stir to disperse evenly, add 100 mg of propylene glycol and 110 mg of sorbitol, add water to 10 mL and stir evenly to obtain a film-forming solution. After standing to defoam, cast in the gel template (6 × 6 cm 2 ), dried and cut into 2 × 2 cm 2 Size, promptly obtains the oral cavity instant film of polyvinylpyrrolidone as film-forming material.

[0063] The above-mentioned oral instant film was recorded as sample 3, and the specific parameters are shown in Table 1.

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Abstract

The invention relates to an oral fast-dissolving film of a xanthophylls-loaded albumin nanoparticle and a preparation method thereof. The preparation method comprises the following steps: preparing the xanthophylls-loaded albumin nanoparticle from xanthophyll by using an anti-solvent precipitation method and then preparing the oral fast-dissolving film of the xanthophylls-loaded albumin nanoparticle by using a solvent casting method. The film prepared in the invention has an intact surface, no bubble, a uniform color and consistent thickness; drug distribution is uniform; and compared with a xanthophyll bulk drug and an oral fast-dissolving film prepared from the xanthophyll bulk drug, the oral fast-dissolving film prepared in the invention is substantially increased in in-vitro release and in-vivo absorption speeds and degrees and obviously improved in bioavailability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and medical technology, especially the field of health care products and food. The invention relates to an oral instant film of active ingredients and a preparation method thereof, in particular to an oral instant film of lutein albumin nanoparticles and its preparation method. Background technique [0002] Lutein (Lutein) is a natural carotenoid widely present in plants, which is mainly extracted from Calendula officinalis. Lutein is a natural pigment, used as a food additive, has pharmacological effects such as protecting eyesight, anti-oxidation, anti-cancer, preventing and treating cardiovascular diseases, etc. It is widely used in many fields of food, health products and pharmaceutical industries, causing It has attracted great attention from related workers at home and abroad. [0003] However, lutein is a lipophilic molecule with poor water solubility, and it is easily oxidized ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/38A61K47/42A61K31/047A61K9/51A61P27/02A61P39/06A61P35/00A61P9/00A23L33/10A23L33/105A23L33/17A23J3/00
CPCA61K9/006A23J3/00A23V2002/00A61K9/5169A61K31/047A61K47/38A61K47/42A23V2200/30
Inventor 王文苹常道潇吴亚楠隋宏朱溶月李治芳
Owner NINGXIA MEDICAL UNIV
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