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Preparation method of L-pyroglutamic acid

A technology of pyroglutamic acid and glutamic acid, which is applied in the field of preparation of L-pyroglutamic acid, can solve the problems of high energy consumption, high equipment requirements, long reaction time and the like, and achieves simple production process and low equipment requirements. , the effect of high product yield and purity

Active Publication Date: 2017-08-15
峨眉山市龙腾生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method requires high energy consumption and extremely high equipment requirements. It is carried out under high temperature and high pressure conditions, the reaction time is long, and a large amount of waste mother liquor needs to be processed.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A kind of preparation method of L-pyroglutamic acid described in the present embodiment comprises the following steps:

[0040] (1) Add glutamic acid or hydrolyzed reclaimed material with a content of more than 98% into the reactor and heat, control the temperature at 150°C, stir once every 4min, stir for 40s, dissolve completely to obtain a feed solution, and add to the Add purified water with a volume of 7% of the feed liquid to the feed liquid, use cooling crystallization and centrifugation, use concentrated crystallization and centrifugation for the mother liquid after subsequent centrifugation, combine each crystallization product to obtain solid A, and centrifuge the mother liquid to be liquid 1;

[0041] (2) Warm up solid A to 40°C in a solvent, wherein the solvent is a mixture of purified water, liquid 1, and liquid 2, and the volume ratio of solid A to solvent is 1:6. Raise the temperature to 70°C, add activated carbon with a weight of 0.3% of the solid A, and ...

Embodiment 2

[0050] The difference between this embodiment and embodiment 1 is:

[0051] (1) Add glutamic acid or hydrolyzed reclaimed material with a content of more than 98% into the reactor and heat, control the temperature at 145°C, stir once every 3min, stir for 30s, dissolve completely to obtain a feed solution, and add to the Add purified water with 5% of the volume of the feed liquid into the feed liquid, use cooling crystallization and centrifugation, use concentrated crystallization and centrifugation for the mother liquor after subsequent centrifugation, combine each crystallization product to obtain solid A, and centrifuge the mother liquor to be liquid 1;

[0052] (2) Warm up the solid A in the solvent to 35°C, the volume ratio of the solid A to the solvent is 1:2, send it into the decolorization tank after the dissolution is complete, raise the temperature to 65°C, then add 0.2% activated carbon by weight of the solid A, After heat preservation and adsorption for 20 minutes u...

Embodiment 3

[0057] The difference between this embodiment and embodiment 1 is:

[0058] (1) Add glutamic acid or hydrolyzed reclaimed material with a content of more than 98% into the reactor and heat, control the temperature at 150°C, stir once every 5min, stir for 50s, dissolve completely to obtain a feed solution, and add to the Add purified water with a volume of 8% of the feed liquid to the feed liquid, use cooling crystallization and centrifugation, use concentrated crystallization and centrifugation for the mother liquid after subsequent centrifugation, combine each crystallization product to obtain solid A, and centrifuge the mother liquid to be liquid 1;

[0059] (2) Warm up the solid A in the solvent to 45°C, the volume ratio of the solid A to the solvent is 1:8, send it into the decolorization tank after the dissolution is complete, raise the temperature to 75°C, then add 0.5% activated carbon by weight of the solid A, After heat preservation and adsorption for 30 minutes under...

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Abstract

The invention discloses a preparation method of L-pyroglutamic acid. The method comprises the following steps: (1) adding glutamic acid or hydrolyzed recovery material into a reaction kettle and then heating, controlling the temperature to be 145-150 DEG C, carrying out intermittent mixing, and enabling the mixture to be completely dissolved so as to obtain feed liquid; adding purified water into the feed liquid, crystallizing for a plurality of times and centrifuging, merging crystallized products to obtain solid A, and merging mother liquor to obtain liquid 1; (2) heating the solid A up to 35-45 DEG C in a solvent, enabling the solid A to be completely dissolved and then sending the dissolved product to a bleaching tank, heating up to 65-75 DEG C, then adding activated carbon, absorbing under the condition of heat preservation, and filtering to obtain a decolored solution; carrying out cooling crystallization on the decolored solution and then centrifuging to obtain a wet product; recycling crystallization mother liquor for a plurality of times, concentrating and recrystallizing to obtain solid B and liquid 2; (3) carrying out vacuum drying on the wet product at the temperature of 80-85 DEG C; after drying is finished, cooling, and detecting to obtain the L-pyroglutamic acid. The method is simple in production technology, mild in reaction conditions, high in product yield and purity, free from emission of pollutants and wastes, and convenient for large-scale continuous production.

Description

technical field [0001] The invention relates to the technical field of amino acid production, in particular to a preparation method of L-pyroglutamic acid. Background technique [0002] L-pyroglutamic acid is an organic compound with the chemical formula C 5 h 7 NO 3 , molecular weight 129.11, scientific name is L-2-pyrrolidone-5-carboxylic acid, appearance is colorless crystal, melting point 152-162°C, specific rotation -11.9° (c=2, H2O), soluble in water and alcohol , acetone and glacial acetic acid, slightly soluble in ethyl acetate, insoluble in ether. [0003] L-pyroglutamic acid is one of the main components of the skin's natural moisturizing factor. Its moisturizing ability far exceeds that of glycerin and propylene glycol, and it is non-toxic and non-irritating. It is an excellent raw material for modern skin care and hair care cosmetics. L-pyroglutamic acid can also inhibit the activity of tyrosine oxidase, thereby preventing the deposition of "melanoid" substan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D207/28
CPCC07B2200/07C07D207/28
Inventor 陈云
Owner 峨眉山市龙腾生物科技有限公司
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