Applications of compound SS-31 in preparing drugs or preparations used for treating atherosclerosis and related diseases

Abstract

The invention provides drugs used for treating atherosclerotic diseases such as carotid artery stenosis, lower extremity atherosclerotic occlusive disease, and coronary heart disease, and more specifically discloses applications of compound Szeto-Schiller-31 (SS-31) in preparing drugs or preparations used for treating atherosclerosis and related diseases, and belongs to the field of medicine, and more specifically belongs to the field of novel pharmaceutical applications of compounds. It is found via experiments that SS-31 is capable of reducing atherosclerosis degree, reducing mouse arterial ROS level obviously, reducing oxidative damage, increasing ATP level, reducing the content of macrophages at atherosclerotic plaques obviously, increasing the content of smooth muscle cells and the content of collagen at atherosclerotic plaques obviously, stabilizing atherosclerotic plaques, improving inflammation level obviously, and reducing expression of lipid intake protein at atherosclerotic plaques; and it is shown by results that SS-31 is capable of treating atherosclerosis and related diseases.

Description

technical field [0001] The invention belongs to the field of chemical medicine and relates to the application of a compound Szeto-Schiller-31 (SS-31) in the preparation of medicines for treating atherosclerotic diseases. Background technique [0002] Atherosclerosis (AS) is the pathological basis of cardiovascular diseases, mainly including carotid artery stenosis, lower extremity arteriosclerosis obliterans and coronary heart disease. Although the clinical manifestations and lesion characteristics of this kind of disease are not the same, they have the same characteristics: the lesion develops slowly, the lumen of the affected artery is narrowed, and the blood supply to the distal tissue is insufficient. Leading cause of human death. At present, the pathogenesis of this type of disease is still controversial. Multiple factors such as genetics, inflammation, high-fat diet, and aging are the common pathogenic factors of this type of disease. The pathological mechanisms inclu...

AI Technical Summary

Problems solved by technology

At present, SS-31 has been applied in many human disease models and has shown certain effects. For example, studies have shown that SS-31 has a certain protective effect on heart failure and hypertensive cardiomyopathy, although heart failure and hypertensive cardiomyopathy The disease is completely different from the atherosclerotic disease involved in this application in terms of the pathogenesis of the disease, the pathophysiological basis, or the corresponding therapeutic drugs, therapeutic targets, and therapeutic strategies, so we cannot give teachings and inspirations, but we still want to Dare to see if SS-31 is protective against atherosclerotic disease

[0006] But so far, there is no report on the anti-atherosclerosis and related diseases of SS-31

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