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Method for acquisition of sugar-reducing medicine and sugar-reducing medicine

A drug and hypoglycemic technology, applied in biochemical equipment and methods, drug screening, drug combination, etc., can solve the problems that have not been reported, and achieve the effect of high universal adaptability, significant efficacy, and good medicinal prospects

Inactive Publication Date: 2017-08-11
PEKING UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Whether SB203580 can improve the blood sugar level of diabetic individuals and delay the development of diabetes has not been reported

Method used

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  • Method for acquisition of sugar-reducing medicine and sugar-reducing medicine
  • Method for acquisition of sugar-reducing medicine and sugar-reducing medicine
  • Method for acquisition of sugar-reducing medicine and sugar-reducing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1 obtains the method for hypoglycemic drug

[0055] 1. Search for anti-inflammatory drugs related to anti-inflammation

[0056] The search method is to obtain the anti-inflammatory drugs by searching various medical websites, literature databases, etc., and obtain the anti-inflammatory drugs through commercially available methods.

[0057] 2. Screening

[0058] From all inflammation-related anti-inflammatory drugs, target drugs that improve the insulin secretion ability of pancreatic β cells or / and insulin resistance are screened, specifically, the rat islet INS-1β cell line is cultured under the culture conditions containing different anti-inflammatory drugs culture, observe the survival and apoptosis of pancreatic islet β cells, apply different anti-inflammatory drugs to animal models of diabetes, and observe blood sugar levels, so as to determine whether different anti-inflammatory drugs cause progressive deterioration or failure of β-cell function (the s...

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Abstract

The invention discloses a method for acquisition of a sugar-reducing medicine and the sugar-reducing medicine, and relates to the technical field of the medical treatment and public health. The method includes steps of through inhibiting inflammation, improving the insulin secretion capacity and the insulin resistance capacity of an early-stage INS-1 pancreas islet Beta cell line and a rodent experimental animal, and realizing the reduction of blood sugar, specifically using a pharmaceutical containing a p38 MAPK inhibitor ingredient SB203580 to realize. The provided sugar-reducing medicine is capable of preparing a pharmaceutical for nursing, delaying and / or treating diabetes or future application in a health care product. The p38 MAPK inhibitor SB203580 is capable of remarkably improving the insulin secretion capacity and the insulin resistance capacity of diabetes patient pancreas islet Beta cells, reducing the blood sugar level of the diabetes patient, and delaying and improving the development of the diabetes through inhibiting the inflammation, and has extensive application prospect in the treatment and nursing of the diabetes.

Description

technical field [0001] The invention relates to a medicine for lowering blood sugar and its application, in particular to a medicine for lowering blood sugar of a p38MAPK inhibitor and its application. Background technique [0002] Diabetes mellitus (DM) is a clinical syndrome caused by the interaction of genetic and environmental factors, and is one of the major endocrine diseases with high morbidity, disability and mortality. According to the different pathogenesis, diabetes mainly includes type 1 diabetes and type 2 diabetes. In my country, type 2 diabetes accounts for more than 90% of the diabetic population, which is a clinical syndrome characterized by long-term hyperglycemia due to relative lack of insulin and insulin resistance. Chronic hyperglycemia can lead to long-term damage, functional deficits, and failure of various tissues, especially the eyes, kidneys, nerves, and cardiovascular system. Clinically, typical symptoms of three excesses (polyphagia, polydipsia...

Claims

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Application Information

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IPC IPC(8): C12Q1/02A61K49/00A61K31/4439A61P3/10
CPCG01N33/507A61K31/4439A61K49/0008C12N2503/02G01N2500/10
Inventor 马晓伟魏晓伟冯楠张俊清郭晓蕙
Owner PEKING UNIV FIRST HOSPITAL
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