Marker capable of developing degradable stent under X rays and preparation method of marker

A technology of marking and stent net, which is applied in the field of medical devices, can solve problems such as large corrosion potential difference, corrosion of metal stents, inseparability, etc., and achieve the effect of solving contact potential difference, improving biocompatibility, and good medical safety

Active Publication Date: 2017-08-11
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problems caused by the first two methods are: (a) The adhesiveness between the developing film and the stent substrate must be firm, even after the stent undergoes crimping and expansion, the two cannot be separated
However, in addition to the use of expensive precious metals, the corrosion potential difference between the degradable metal bracket and the noble metal development mark is large. Once in contact, the metal bracket equivalent to the anode will quickly corrode and fail.
It can be seen that there are still many technical defects in the imaging technology of interventional stents, and further improvement is still needed.

Method used

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  • Marker capable of developing degradable stent under X rays and preparation method of marker
  • Marker capable of developing degradable stent under X rays and preparation method of marker
  • Marker capable of developing degradable stent under X rays and preparation method of marker

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Experimental program
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Effect test

Embodiment 1

[0034] In this embodiment, the in vitro imaging effect of its imaging marks under medical X-rays refers to Figure 1~2 .figure 1 The surface treatment temperatures (from left to right) of the four developing bodies in the lower half shown are 300°C, 400°C, 700°C and 800°C, respectively. The thickness of the marking material is 0.040mm. The development marks of four conditions all performed well in the development effect of medical X-ray (see figure 2 ). The test results of its resistance show that except the resistance of the 300°C sample is small, the resistance values ​​of the other three samples are all infinite. After XRD analysis of the above four samples, the results show that the 800°C sample contains a large amount of Ta 5 o 2 . It is actually a white powdery substance on the surface (see figure 2 , visible to the naked eye). The developing marking material obtained in the interval between 400°C and 700°C is a better choice in the present invention. The diame...

Embodiment 2

[0037] In this embodiment, the development effect of the large animal experiment in vivo under the medical X-ray is referred to Figure 4 . In this embodiment, the iliac artery of the experimental animal pig is used as the experimental blood vessel, and the processing method of the stent and the production process of the imaging mark are as described in Embodiment 1. The difference is that the surface of the stent in this implementation is sprayed with drug coating. The thickness of the stent mesh is 0.130mm, and the diameter of the developing mark is 0.38mm, and the thickness is between 0.095mm and 0.105mm. In this embodiment, the average thickness of the oxygen-rich layer of the developed mark is about 350 nm.

[0038] In order to compare the developing effects, this embodiment verifies the developing effects of adding developing marks at two positions. One is to set only one reserved hole at both ends of the bracket. The plane formed by the straight line passing through...

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Abstract

The invention relates to the field of medical apparatus and instruments, and in particular relates to a marker capable of developing a degradable stent under X rays and a preparation method of the marker. Tantalum having good biocompatibility and developing effect serves as a material for manufacturing the developing marker, through surface treatment, while the developing property under the X rays is not reduced and the biocompatibility is improved, the galvanic corrosion effect caused by corrosion due to contact of different metals (the developing point and the degradable metal stent) is completely avoided. The developing markers of different size specifications are prepared and placed at the reserved holes of the degradable stents of different specifications, after implantation in the stents, along with the gradual reconstruction and self-healing of the vascular function of the implanted part, the side surface as well as the upper and lower surfaces of the developing marker are respectively tightly bounded by netting wires and blood vessels, and drug coatings wrap the surfaces of the developing point and the stents. The developing marker can bear the long-term vascular contraction movement and blood flow scouring and can not fall off, thus having good medical safety and simple practical operability.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a marker capable of developing a degraded bracket under X-rays and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, the change of eating habits, the continuous increase of work and life pressure, the increasingly serious environmental pollution, the number of people suffering from coronary heart disease is increasing day by day. Coronary heart disease is an organic disease of myocardial dysfunction caused by coronary artery stenosis and insufficient blood supply, so it is also called ischemic cardiomyopathy. It is a kind of heart disease with high clinical incidence rate. At present, minimally invasive implantation of vascular stents is widely used for treatment. This technology uses techniques such as puncture, catheter, balloon catheter expansion and intravascular stent placement to expand and recanalize narrowed and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/18A61L31/14A61L31/02
CPCA61L31/022A61L31/14A61L31/18
Inventor 唐明强张炳春郑丰陈姗姗杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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