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Application of nano self-assembly hydrogel to anti-adhesion material used in surgery

A nano-self-assembly, hydrogel technology, applied in the medical and biological fields, can solve problems such as stimulating nerves, affecting nerve demyelination repair, and adhesion nerve recurrence, avoiding impact and damage, easy to observe and research, good biological Compatibility effect

Inactive Publication Date: 2017-08-11
郑敦武 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In the prior art, the anti-adhesion pads used in clinical operations, such as Teflon cotton, have defects in practical applications, including as 1, easy adhesion with surrounding tissues; 2, stimulation of nerves leads to ineffectiveness; 3, adhesion of nerves leads to recurrence; 4. Affect the repair of nerve demyelination

Method used

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  • Application of nano self-assembly hydrogel to anti-adhesion material used in surgery
  • Application of nano self-assembly hydrogel to anti-adhesion material used in surgery
  • Application of nano self-assembly hydrogel to anti-adhesion material used in surgery

Examples

Experimental program
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Effect test

Embodiment 1

[0051] Accurately weigh 1mg of RADA16-1 polypeptide hydrogel powder, pour it into a sterile tube, draw 1mL of sterilized water with a pipette gun, mix gently for later use, and obtain 0.1% polypeptide hydrogel.

Embodiment 2

[0053] Accurately weigh 10mg of RADA16-1 polypeptide hydrogel powder, pour it into a sterile tube, use a pipette to draw 1mL of sterilized water, mix gently for later use, and obtain 1% polypeptide hydrogel.

Embodiment 3

[0054] The purposes of embodiment 3 nano self-assembled hydrogels in artificial dura mater material

[0055] The treatment of craniocerebral trauma is to open the brain tissue to remove the hematoma and repair the dural defect. However, during the operation, contusion and bleeding on the brain surface often occur, and the dural defect cannot be sutured, which hinders the smooth progress of the operation. Figure 3A , 3B shown.

[0056] In order to solve the above problems, the dura mater is often used for covering or suturing, such as Figure 4A , 4B shown. Although this kind of dura mater repair can play the role of isolation and prevention of adhesion, there are still many deficiencies: insufficient plasticity; insufficient adhesion; foreign matter (not absorbed, thickened after absorbing water); Promote the restoration of nerve function.

[0057] The above-mentioned self-assembled polypeptide hydrogel prepared according to Example 2 is made into a liquid artificial dur...

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Abstract

The invention relates to the fields of medicine and biotechnology, in particular to application of nano self-assembly hydrogel to an anti-adhesion material used in surgery, including application to an artificial duramater material, application to an anti-adhesion material used in cranial nerve surgery, and application to a material for preventing soft tissue adhesion in surgery. The invention further discloses an anti-adhesion material used in surgery, wherein the anti-adhesion material contains the nano self-assembly hydrogel. The nano self-assembly hydrogel is aqueous solution of RADA16-1 polypeptide. The nano self-assembly hydrogel has certain constituents and contains no animal heterologous protein or pathogen, so that impact and damage to cells by uncertain constituents can be effectively avoided. The nano self-assembly hydrogel can be naturally degraded into amino acid in the body, has no toxicity and does no harm to cell growth, and has high biocompatibility. The nano self-assembly hydrogel is transparent in appearance, so that the growth state of cells can be observed and studied easily, and operation is convenient.

Description

technical field [0001] The invention relates to the fields of medicine and biotechnology, in particular to the application of nanometer self-assembled hydrogel in anti-adhesion in surgery. Background technique [0002] All water-soluble or hydrophilic polymers can form hydrogels through certain chemical cross-linking or physical cross-linking. These polymers can be divided into two categories according to their sources, natural and synthetic. Natural hydrophilic polymers include polysaccharides (starch, cellulose, alginic acid, hyaluronic acid, chitosan, etc.) and polypeptides (collagen, poly-L-lysine, poly-L-glutamic acid, etc.) . Synthetic hydrophilic polymers include alcohol, acrylic acid and its derivatives (polyacrylic acid, polymethacrylic acid, polyacrylamide, poly-N-polyacrylamide, etc.). [0003] Self-assembled polypeptide hydrogels are spontaneously assembled between polypeptide molecules through non-covalent bonds such as hydrogen bonds, electrostatic interacti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14A61L27/22A61L27/52
CPCA61L31/047A61L27/227A61L27/52A61L31/145C08L89/00
Inventor 郑敦武韩蓝青李世亭许东升
Owner 郑敦武
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