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A kind of compound polysaccharide hemostatic composition and its preparation method and application

A technology of complex polysaccharides and compositions, which is applied in the fields of application, drug delivery, and pharmaceutical formulations, and can solve problems such as unfavorable product molding and use

Active Publication Date: 2020-07-07
SAIKE SAISI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these three kinds of hemostatic materials have a certain improvement in water absorption rate, they can also be absorbed by the body and have no toxic and side effects. Crunchy and brittle, not conducive to product molding and use

Method used

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  • A kind of compound polysaccharide hemostatic composition and its preparation method and application
  • A kind of compound polysaccharide hemostatic composition and its preparation method and application
  • A kind of compound polysaccharide hemostatic composition and its preparation method and application

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preparation example Construction

[0045] (1) Preparation of micro-crosslinked modified starch: Weigh two or more raw materials of modified starch, add them into distilled water respectively, and keep stirring to make modified starch liquid; the mass ratio of modified starch raw material to distilled water is 1:( 10-100). Use sodium hydroxide solution to adjust the pH value of each modified starch solution to 8-11, adjust the temperature of the modified starch solution to 30°C-80°C, add cross-linking agents to each modified starch solution, stir vigorously, and micro-crosslinking occurs Reaction, the reaction time is 0.5-48 hours, the quality of the crosslinking agent is 0.1wt%-8wt% of the quality of each modified starch raw material; then it is washed with water, dehydrated with absolute ethanol, and dried at 30°C-60°C for 2-48h, Several kinds of micro-crosslinked modified starches were obtained;

[0046] Modified starch raw materials can be etherified starch, specifically carboxymethyl starch, hydroxyethyl s...

Embodiment 1

[0055] (1) Weigh 3g of carboxymethyl starch and add it to 100ml of distilled water, stir continuously to make carboxymethyl starch liquid, pour it into the reaction kettle, the temperature of the water bath is 60°C, adjust the pH value between 8-11, add 0.2 g of epichlorohydrin, vigorously stirred for 3 hours; then washed with water, dehydrated with absolute ethanol, and air-dried at 50°C for 4 hours to obtain slightly cross-linked carboxymethyl starch.

[0056] Weigh 3g of hydroxyethyl starch and add it to 100ml of distilled water, stir continuously to make hydroxyethyl starch liquid, pour it into the reaction kettle, the temperature of the water bath is 60°C, adjust the pH value between 8-11, add epoxy chlorine Propane 0.2g, vigorously stirred for 3 hours; then washed with water, dehydrated with absolute ethanol, and air-dried at 50°C for 4 hours to obtain slightly cross-linked hydroxyethyl starch.

[0057] (2) Take by weighing 0.5g slightly cross-linked carboxymethyl starch...

Embodiment 2

[0064] Step (1) is with embodiment 1.

[0065] (2) Weigh 0.99 g of slightly cross-linked carboxymethyl starch and 0.01 g of slightly cross-linked hydroxyethyl starch, add them into 90 ml of distilled water, and stir continuously to prepare starch liquid.

[0066] (3) Weigh 0.05 g of hydroxyethyl cellulose, add it to 5 ml of distilled water, and keep stirring to make a hydroxyethyl cellulose solution;

[0067] (4) Mix the liquids obtained in the above steps (2) and (3) under stirring, then add 0.15 g of propylene glycol, and stir vigorously for 1 hour.

[0068] (5) Pour the material liquid obtained in step (4) into a freeze-drying mold, pre-freeze in a freezer at -25°C for 4 hours, and then vacuum freeze-dry at -35°C and a vacuum degree of less than 20Pa After 40 hours, a spongy compound polysaccharide hemostatic composition was obtained.

[0069] Get the above-mentioned block composition of 10mm * 50mm specification, measure its tensile strength by the method of embodiment 1...

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Abstract

The invention discloses a composite polysaccharide hemostatic composition and a preparation method and application thereof. The composite polysaccharide hemostatic composition is prepared from the following components in percentage by mass: 20% to 99% of absorbable composite starch, 0.1% to 60% of forming agent, and 0.001% to 20% of plasticizer. The composite polysaccharide hemostatic composition has the advantages that the water in blood can be quickly adsorbed by the molecular structure, the blood platelet, erythrocyte and binding protein (thrombin and fibrinogen) are concentrated, the normal blood coagulation speed in the dewatering process is accelerated, and the hemostatic function is quickly realized; the gel and adhesive substrate can be formed to provide mechanical barriers for the subsequent hemostatic operation, and the probability of bleeding again is reduced by the super-hydrophilic property and adhesion property; the degrading speed is higher, and the use safety of a patient is improved.

Description

technical field [0001] The invention relates to the technical field of medical hemostatic compositions, in particular to a complex polysaccharide hemostatic composition and its preparation method and application. Background technique [0002] Hemostasis is an important link in the operation of various departments in the hospital. Reducing bleeding and shortening the operation time play an important role in the success of the operation and the safety of the patient. At present, mechanical hemostasis is still a simple and effective way to stop bleeding in certain surgical sites as long as the treatment method is appropriate. However, when some intraoperative bleeding cannot be stopped by appropriate mechanical methods, absorbable hemostatic materials that can be directly applied to the bleeding site play an important role. Therefore, it is particularly important to provide a hemostatic material that is safe, effective, convenient to use and easy to process. [0003] The comm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/00C08L3/08C08L1/28C08L5/08C08J3/24
CPCA61L24/0042A61L24/08A61L2400/04C08J3/24C08J2303/08C08L3/08C08L3/04C08L1/284C08L5/08C08L1/286
Inventor 李玲宋光民魏振宇刘文一鹿中高赵成如宋祥宋翠翠祝金凤张春霞闫永丽
Owner SAIKE SAISI BIOTECH CO LTD
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