Crystalline lens biomechanics and optical property noninvasive in-vivo imaging system and measuring method

Abstract

The invention discloses a crystalline lens biomechanics and optical property noninvasive in-vivo imaging system and a measuring method. The ultrasonic load system provides mechanical waves capable of enabling a crystalline lens to deform, a spectral domain OCT system achieves the structure and elastic imaging of the crystalline lens; on the basis of the yoke eliminating technology, OCT full-range imaging is achieved, full anterior segment two-dimensional or three-dimensional structure images from the anterior corneal surface to the retrolental surface, morphological and optical characteristic parameters of the crystalline lens are obtained through calculation, and a crystalline lens topographic map is constructed. Meanwhile, the phase sensitive OCT technology is utilized, strain distribution in the depth direction of the crystalline lens is obtained, and a two-dimensional or three-dimensional biomechanical characteristic distribution diagram of the crystalline lens is obtained through rebuilding. High-resolution imaging and precision measurement of biomechanics and optical properties of the crystalline lens provide the more comprehensive and complete imaging surveying basis for fundamental research, early diagnosis, operation plan formulating and postoperation result evaluation of cataract and other crystalline lens diseases, and the important practical significance and clinical significance are achieved.

Description

technical field [0001] The present invention relates to lens optical coherence elastography and full-range imaging optical coherence tomography technology, in particular to a method of using spectral domain optical coherence tomography technology combined with phase-sensitive detection technology to analyze the biomechanical and optical properties of the lens Systems and methods for non-invasive in vivo imaging and measurement. Background technique [0002] The lens is one of the important refractive media of the eye. Physiological and pathological changes in its biomechanical and optical properties (such as elasticity, refractive power, and refractive index, etc.) will lead to the occurrence and development of many ophthalmic diseases, such as presbyopia and cataract. Cataract is the world's first blinding eye disease. Aging is its most common etiology and the incidence increases with age. As the life expectancy of the population increases, the social impact of cataracts ...

AI Technical Summary

Problems solved by technology

However, there are still several problems in this system: 1) Due to the limited imaging depth of the system, only the imaging from the cornea to the front surface of the lens can be achieved, and the structure and elasticity information of the middle and rear segments of the lens cannot be obtained; 2) The oblique incidence loading method cannot To achieve the coaxiality of the beam and the ultrasound beam, the inducing factors of its longitudinal deformation are various; 3) only the elastic information of a certain position on the sample surface can be realized, but not the complete information, which is far from enough for the diagnosis and treatment of lens diseases , limited clinical significance; 4) failed to achieve in vivo imaging, limiting its research and development in the clinical field

But so far, no system and method have been found in the existing technology and equipment that can simultaneously perform non-invasive in vivo imaging and measurement of lens biomechanical and optical property information

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