Absorbable artificial dura mater having anti-infection function, preparation method and application thereof

An artificial dura mater and anti-infection technology, which is applied in the field of biomedical materials, can solve the problems of no mention of artificial dura mater anti-infection performance, difficulty in industrial development and clinical application, and limitation of anti-infection activity, so as to achieve easy control of product quality , good application prospects, and the effect of avoiding the risk of cancer

Inactive Publication Date: 2017-07-14
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the artificial dura mater can achieve the purpose of dura mater regeneration and prevention of scar and adhesion, it has the following disadvantages: (1) the outer fiber is made of polylactic acid / glycolic acid copolymer and chitosan, and when chitosan When the sugar content is low, the anti-infective activity will inevitably be limited, and the anti-infective properties of this artificial dura mater are not mentioned in the patent; (2) During clinical use, the outer layer and inner layer fibers need to be placed separately At the location of the meningeal defect, an adhesive needs to be applied between the two layers, which greatly increases the inconvenience during clinical use.
At the same time, the artificial dura mater, as a drug-machine combination product, has problems such as registration and approval difficulties, and it is not easy to realize industrial development and clinical application.

Method used

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  • Absorbable artificial dura mater having anti-infection function, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] A polylactic acid-caprolactone copolymer with a weight average molecular weight of 300,000 is dissolved in hexafluoroisopropanol at a concentration of 0.08 g / ml; a chitosan with a relative molecular weight of 300,000 and a degree of deacetylation of 85% is dissolved In the mixed solution of hexafluoroisopropanol and acetic acid, the volume fraction of acetic acid is 2%, and the solution concentration is 0.015 g / ml; a uniform and stable solution is formed after stirring at room temperature respectively. Afterwards, the two solutions are put into syringes respectively, and the needles of the syringes are connected to a high-voltage power supply. The solution supply flow rate was controlled at 1 ml / hour, the applied voltage was 15 kV, the distance between the high-voltage end and the ground end was 15 cm, and a rotating drum with a diameter of 8 cm was used as a collection device at a speed of 100 rpm. After the polylactic acid-caprolactone copolymer solution and the chito...

Embodiment 2

[0062] The L-polylactic acid with a weight-average molecular weight of 300,000 is dissolved in chloroform, and the concentration is 0.1 g / ml; the chitosan with a relative molecular weight of 500,000 and a deacetylation degree of 90% is dissolved in trifluoroethanol and acetic acid. In the mixed solution, the volume fraction of acetic acid is 5%, and the solution concentration is 0.01 g / mL; a uniform and stable solution is formed after stirring at room temperature respectively. Afterwards, the two solutions are put into syringes respectively, and the needles of the syringes are connected to a high-voltage power supply. The solution supply flow rate was controlled at 1.5 ml / hour, the applied voltage was 17.5 kV, the distance between the high-voltage end and the ground end was 12.5 cm, and a rotating drum with a diameter of 8 cm was used as a collection device at a speed of 100 rpm. A double-layer structure nanofiber membrane with a thickness of about 0.25 mm can be collected aft...

Embodiment 3

[0065] Dissolve polylactic acid-glycolic acid copolymer with a weight average molecular weight of 250,000 in acetone at a concentration of 0.2 g / ml; dissolve chitosan with a relative molecular weight of 700,000 and a deacetylation degree of 95% in trifluoroacetic acid , the solution concentration is 0.01 g / ml; a uniform and stable solution is formed after stirring at room temperature respectively. Afterwards, the two solutions are put into syringes respectively, and the needles of the syringes are connected to a high-voltage power supply. The solution supply flow rate was controlled at 2 ml / hour, the applied voltage was 20 kV, the distance between the high voltage end and the ground end was 20 cm, and a rotating drum with a diameter of 8 cm was used as the collection device at a speed of 100 rpm. After spinning polylactic acid-glycolic acid solution and chitosan solution in turn, a double-layer structure nanofiber membrane with a thickness of about 0.15 mm can be collected.

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Abstract

The invention relates to an absorbable artificial dura mater having anti-infection function, and a preparation method and an application thereof. The anti-infection artificial dura mater is composed of a nano-fiber membrane having a double layer structure and a high-molecular material having a three-dimensional porous structure. The nano-fiber membrane in the double layer structure is composed of a degradable polyester nano-fiber membrane and a chitosan nano-fiber membrane. The high-molecular material in the three-dimensional porous structure is made from a natural high-molecular substance and is located inside and on the surface of the nano-fiber membrane. The absorbable artificial dura mater has good anti-infection function and can effectively prevent post-operation intracranial infection, can bear certain suture force without tearing and edge falling off, is deformable but is free of damage. Meanwhile, the nano microporous structure can effectively prevent tissue adhesion and has excellent hydration property, compliance and adhesivity, so that the artificial dura mater can be directly used in clinical application in an attachment manner, thereby achieving suture-free fixation. The artificial dura mater can be completely degraded and absorbed, thereby avoiding carcinogenic risk of the membrane sheets.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an absorbable artificial dura mater with anti-infection function and its preparation method and application. Background technique [0002] The dura mater is a layer of connective tissue that lines the inside of the skull and the outside of the brain and acts as a natural barrier to protect brain tissue. Open skull injury, tumor metastasis, and other brain diseases can cause dural defects, which in turn lead to cerebrospinal fluid leakage. At the same time, intracranial infection caused by bacterial meningitis is still a common serious complication after craniocerebral surgery. Reported in the literature, the incidence of postoperative intracranial infection is still as high as 0.2% to 5%. Once an infection occurs after the operation, it will not only greatly increase the medical expenses of the patient, but also lead to the failure of the operation and death in s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/50A61L27/18A61L27/20A61L27/40
CPCA61L27/18A61L27/20A61L27/50A61L27/58C08L67/04C08L5/08
Inventor 窦源东任志伟孙先昌尹晓彤陈振华
Owner YANTAI ZHENGHAI BIO TECH
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