Medical coating system having double-term and/or multi-term release speed rate

A technology of coating system and release rate, applied in coatings, medical science, catheters, etc., can solve the problems of inability to prevent infection, and achieve good anti-infection, strong hydrophilicity, and slow release rate effects

Inactive Publication Date: 2007-11-07
FUTAIMINDE MEDICINE TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The infection rate of closed drainage catheter is 5%-10% per day, and the infection rate of open catheter is higher, and systemic application of antibiotics cannot prevent infection (Kaye D & Hessen MT, Infections Associated with Indwelling Medical Devices( Ed. Bisno A & Waldvogel FA), 1994, P291-307)

Method used

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  • Medical coating system having double-term and/or multi-term release speed rate
  • Medical coating system having double-term and/or multi-term release speed rate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation of three different molecular weight polyethylene oxide coating liquids.

[0048] Coating liquid 1: PEO (molecular weight 4×10 6 , Union Carbide Corp.) is 2%, silver oxide (sold by Sigma) is 0.2%. PEO and silver oxide are uniformly mixed in isopropanol / water (80:20) solution to prepare coating liquid 1.

[0049] Coating liquid 2: PEO (molecular weight 3×10 5 , Union Carbide Corp.) is 3%, silver oxide (sold by Sigma) is 0.2%. PEO and silver oxide are uniformly mixed in isopropanol / water (80:20) solution to prepare coating liquid 2.

[0050] Coating liquid 3: PEO (molecular weight 2×10 4 , Union Carbide Corp.) is 8%, silver oxide (sold by Sigma) is 0.2%, PEO and silver oxide are uniformly mixed in isopropanol / water (80:20) solution to prepare coating liquid 3.

[0051] The three latex catheters were respectively immersed in the above three coating solutions, and then dried in an oven at 80° C., and the above steps were repeated once to form three polyethylene o...

Embodiment 2

[0055] A two-layer coating system with a base layer and an outer layer is formed on the latex catheter.

[0056] First, the coating solution for the base layer and outer layer of the catheter is prepared as follows.

[0057] Base layer: PEO (molecular weight 4×10 6 , Union Carbide Corp.) is 2%, and silver oxide is 0.2% (sold by Sigma). PEO and silver oxide are uniformly mixed in a solution of isopropanol / water (80:20) and added to the solution In the stoichiometric ratio of ethyleneimine to PEO of 1:1, ethyleneimine is added to form a base layer coating liquid.

[0058] Outer layer: PEO (molecular weight 2×10 4 , Union Carbide Corp.) is 8%, and silver oxide (sold by Sigma) is 0.2%. PEO and silver oxide are uniformly mixed in an isopropanol / water (80:20) solution.

[0059] Then, the latex catheter is first immersed in the base layer coating solution, dried at 80°C, then dipped in the outer layer coating solution, and dried at 80°C to form a base layer and outer layer double-layer c...

Embodiment 3

[0063] The anti-infective effect test of the catheter with the coating system of the present invention.

[0064] For the catheter section of the double-layer coating system with a base layer and an outer layer formed in Example 2, a bacteriostatic zone determination test (without a silver release test) was performed to test its anti-infection effect.

[0065] In the inhibition zone test, the test medium is Muller=Hinton agar, and the test bacteria is E. coli. The zone of inhibition after 24 hours was 8.5 mm.

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Abstract

A medical coated layer system with different medicine releasing speeds is composed of a substrate made of high-molecular polyepoxyethane or polyethanediol carried medicine or bioactive substances and additive for slow releasing and at least one external layer made of low-molecular polyepoxyethane or polyethanediol carried medicine or bioactive substances. It can be used exteriorly, or in blood vessel, or as implant.

Description

Technical field [0001] The invention relates to a medical coating system with dual-phase or multi-phase release rate and its application. The invention particularly relates to a medical catheter and its manufacturing method. Background technique [0002] Although biological materials and medical devices made from them are widely used in modern medicine, their effects are not yet satisfactory. Biological incompatibility of different degrees and properties is a basic and common problem, which is manifested in the initiation of blood coagulation and the immune response of various body fluids and cells. Another issue that has attracted widespread attention in recent years is that the viscous effect of biological materials on bacteria leads to the easy formation of bacterial films on the surface. The application of biological materials / medical equipment is often accompanied by infections, and such infections are difficult to treat. As a result, the use of the biomaterial / medical equip...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/08A61L29/16A61L31/08A61L31/16
Inventor 尹勤李柠
Owner FUTAIMINDE MEDICINE TECH BEIJING
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