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Electrostatic spinning-based pressure-sensitive adhesive patch, and preparation method thereof

A pressure-sensitive adhesive patch and electrospinning technology, which is applied in the direction of electrospinning, rayon manufacturing, and medical preparations of non-active ingredients, can solve problems such as poor adhesion, and achieve high porosity and drug utilization. High, good air permeability

Active Publication Date: 2017-07-14
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the field of drug patches, there are different types of matrices such as black plasters, rubber plasters, hydrogels, and pressure-sensitive adhesives. Among them, the pressure-sensitive adhesive matrix has many advantages such as convenient use, high drug loading, and reusability. Concerned, its typical representatives are styrene-butadiene-styrene block copolymer (SBS), styrene-isoprene-styrene block copolymer (SIS) and their hydrogenated modified block copolymers Lipophilic pressure-sensitive adhesives based on substances (SEBS, SEPS) and hydrophilic pressure-sensitive adhesives based on acrylates are suitable for lipophilic drugs and hydrophilic drugs respectively. Compared with the two, the adhesiveness of the latter poor adhesion

Method used

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  • Electrostatic spinning-based pressure-sensitive adhesive patch, and preparation method thereof
  • Electrostatic spinning-based pressure-sensitive adhesive patch, and preparation method thereof
  • Electrostatic spinning-based pressure-sensitive adhesive patch, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) 80 parts by weight of SIS thermoplastic elastomer, 80 parts by weight of petroleum resin, 10 parts by weight of propylene glycol, 50 parts by weight of oleanolic acid and 2 parts by weight of N,N-dibutylamino disulfide Zinc formate is fully dissolved in a mixed solvent of tetrahydrofuran, cyclohexane and gasoline (wherein the mass ratio of tetrahydrofuran to cyclohexane and gasoline is 2:1:1), and the preparation of a spinning solution with a solid concentration of 16wt% .

[0038] (2) Put the above-mentioned spinning solution into a syringe, place it on an electrospinning device for spinning, and obtain the drug-loaded SIS hot-melt pressure-sensitive adhesive fiber film, and its structure is as follows: figure 1 shown. The spinning collection method is flat plate collection or drum collection. The surface of the receiving flat plate or drum is pasted with a backing material, and the receiving thickness is 200±20 μm. After collection, the backing material is added ...

Embodiment 2

[0040] (1) 80 parts by weight of polyethylene oxide, 10 parts by weight of propylene glycol and 2 parts by weight of N,N-zinc dibutylcarbamate in a mixed solvent of water and ethanol (wherein water and ethanol The mass ratio is 3:7), and the spinning solution with a solid concentration of 7wt% is prepared.

[0041] (2) Put the above-mentioned spinning solution into a syringe, and place it on an electrospinning device for spinning to obtain a polyethylene oxide fiber membrane, the structure of which is as follows: figure 2 shown. The collection method of spinning is flat plate collection or drum collection, and the surface of the receiving flat plate or drum is pasted with a backing material, and the receiving thickness is 200±20μm. After collection, the backing material is added to obtain a polyethylene oxide fiber membrane blank patch . Electrospinning parameters: voltage 15kv, spinning speed 1ml / h, receiving distance 20cm, relative humidity 30%.

Embodiment 3

[0043](1) 80 parts by weight of polyethylene oxide, 50 parts by weight of geniposide, 10 parts by weight of propylene glycol and 2 parts by weight of N,N-dibutylcarbamate zinc, in water and ethanol fully dissolved in a mixed solvent (wherein the mass ratio of water and ethanol is 3:7), and a spinning solution with a solid concentration of 10wt% was prepared.

[0044] (2) Put the above-mentioned spinning solution into a syringe and place it on an electrospinning device for spinning to obtain a drug-containing nanofiber membrane, the structure of which is as follows: image 3 shown. The collection method of spinning is flat plate collection or drum collection. The surface of the receiving plate or drum is pasted with backing material, and the receiving thickness is 200±20μm. After collection, the backing material is added to obtain the hydrophilic fiber membrane drug-containing external patch . Electrospinning parameters: voltage 15kv, spinning speed 1.0ml / h, receiving distanc...

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Abstract

The invention provides an electrostatic spinning-based pressure-sensitive adhesive patch, and a preparation method thereof, and belongs to the technical field of patch for external use. According to the preparation method, electrostatic spinning is adopted so as to obtain two kinds of nano fibers containing a lipophilic drug and a hydrophilic drug respectively, and release channels to the skin of different drugs are provided; wherein the nano fiber composed of a styrene series pressure-sensitive adhesive matrix possesses pressure-sensitive bonding capacity, local adhesion is observed, and an interpenetrating network structure is formed together with fiber composed of a hydrophilic drug release matrix, so that adhesion of a system onto skin surface is realized effectively. The advantages are that: firstly, electrostatic spinning is adopted to prepare the amphiphilic drug-containing nano fiber matrix, so that two phase incompatibility is avoided; secondly, the lipophilic drug and the hydrophilic drug can be independently stored in the corresponding nano fiber matrixes, and released, so that drug utilization ratio is high; and in addition, the amphiphilic drug-containing nano fiber matrix prepared via electrostatic spinning is high in porosity and permeability.

Description

technical field [0001] The invention belongs to the technical field of external patches, and relates to a pressure-sensitive adhesive patch based on electrospinning and a preparation method thereof. Background technique [0002] Topical patches are administered through the skin surface, allowing the drug to enter the systemic circulation through the skin at a near constant rate, producing systemic or local therapeutic effects. It can avoid the discomfort caused by oral administration and the first-pass effect of the liver; it can overcome the adverse reactions caused by excessive blood concentration caused by excessive absorption; the administration is flexible, stable and controllable, and is not affected by the pH value in the digestive tract, food, etc. factors. It is mainly composed of two parts: a matrix and a drug. The drug is dispersed in the matrix. The role of the matrix is: first, as a material carrier for the drug; second, to provide a channel for the delivery of...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/10A61K47/32D01F8/10D01F1/10D01F6/94D01F6/50D01F8/18D01F9/00D04H1/728D01D5/00
CPCA61K9/7053A61K9/7069D01D5/003D01D5/0076D01F1/10D01F6/50D01F6/94D01F8/10D01F8/18D01F9/00D04H1/728
Inventor 赵忠夫张岩东张春庆鲁金明刘伟刘沛莹孟繁志
Owner DALIAN UNIV OF TECH
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