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Meropenem palladium-carbon catalyst preparation method and catalyst prepared through same

A technology of palladium carbon catalyst and meropenem, which is applied in the field of chemical catalyst preparation, can solve problems such as cumbersome steps, harsh preparation requirements, and poor catalytic selectivity of the catalyst, and achieve simple preparation process, small negative impact on the environment, and improved reaction selectivity Effect

Active Publication Date: 2017-06-20
JIANGXI HANS PRECIOUS METALS CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The method requires harsh preparation, cumbersome steps, poisonous metal tin, and is not conducive to the later recycling of precious metal palladium; especially the particle size of the palladium metal particles prepared by it is not suitable, so that the catalytic selectivity of the catalyst is poor and cannot be used. Taking into account the catalytic activity, which makes the effect of removing protective groups such as p-nitrobenzyl (-PNB) and p-nitrobenzyloxycarbonyl (-PNZ) under the conditions of various potential side reactions in the preparation process of meropenem poor

Method used

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  • Meropenem palladium-carbon catalyst preparation method and catalyst prepared through same

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Embodiment 1

[0027] 1) Weigh palladium chloride, such as 1.68 g, dissolved in as little hydrochloric acid as possible, and then neutralize and react with, for example, a 1.0 mol / L sodium hydroxide aqueous solution to obtain palladium hydroxide precipitate, and wash with deionized water until there is no chloride ion.

[0028] 2) The freshly prepared palladium hydroxide is dissolved in as little as possible, for example, 4.0 moL / L sodium hydroxide solution, and the palladium concentration is diluted, for example, 0.1 moL / L.

[0029] 3) Control the temperature to 50°C-60°C, stir and adsorb the alkaline impregnation solution with, for example, 19.0g coconut shell activated carbon for a certain period of time, such as 4h, and impregnate the palladium solution onto the activated carbon carrier; in this embodiment, the activated carbon is preferably subjected to, for example, 5% nitric acid Boiling to activate, deionized water washing in this notice.

[0030] 4) Control the temperature to 80-100°C, and...

Embodiment 2

[0032] In this embodiment, except that potassium hydroxide is used instead of sodium hydroxide in step 2), other steps and parameters are preferably the same as those in embodiment 1.

Embodiment 3

[0034] In this embodiment, except that ammonium hydroxide is used instead of sodium hydroxide in step 2), other steps and parameters are preferably the same as those in Example 1.

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Abstract

The invention belongs to the field of chemical catalyst preparation and particularly discloses a meropenem palladium-carbon catalyst preparation method. The palladium-carbon catalyst is obtained by dipping palladium hydroxide solution on an activated carbon carrier and restoring through a reducing agent. The preparation method comprises the steps: 1) utilizing a palladium-contained compound to prepare palladium hydroxide; 2) preparing palladium hydroxide solution; 3) throwing activated carbon into the palladium hydroxide solution to prepare dipping slurry; 4) performing chemical reduction reaction on the dipping slurry. The invention further discloses meropenem palladium-carbon catalyst prepared through the method. The palladium-carbon catalyst disclosed by the invention has a simple preparation technological process and strong selective pertinence; furthermore, preparation raw materials are simple and easy to obtain, and a reaction product is green and environment-friendly; the palladium-carbon catalyst is mainly applied to preparation of meropenem in carbapenems antibiotics and also has other wide application in the field of medical treatment.

Description

Technical field [0001] The invention belongs to the field of chemical catalyst preparation, and specifically relates to a preparation method of a palladium-carbon catalyst for meropenem and a palladium-carbon catalyst prepared by the method. Background technique [0002] Meropenem is the most important kind of carbapenem antibiotics and is widely used in the field of medical drug preparation. As the latest generation of antibiotics, it has a broad spectrum of anti-Gram-positive and gram-negative bacteria in vitro, and is stable to human kidney dehydropeptidase I, and can be used alone. During the chemical synthesis of the drug, the protective group needs to be removed with a precious gold palladium carbon catalyst. In this process, it is necessary to remove p-nitrobenzyl (-PNB) and p-nitro under conditions involving a variety of potential side reactions (such as double bond, carbonyl, nitro hydrogenation and side chain sulfur bond hydrogenolysis) Benzyloxycarbonyl (-PNZ) has hi...

Claims

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Application Information

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IPC IPC(8): B01J23/44C07D477/20C07D477/06
CPCB01J23/44C07D477/06C07D477/20
Inventor 王临才郁丰善何治鸿相亚波李永敏赵栋云叶建宏程龙
Owner JIANGXI HANS PRECIOUS METALS CO LTD
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