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Degradable radioactive particle chain with shape memory function

A technology of radioactive particles and functions, applied in the field of degradable radioactive particle chains, can solve the problems of dose deviation, increase the indications of radioactive particle implantation, lack of supporting force, etc., and achieve the effect of low melting point

Active Publication Date: 2017-06-13
HTA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Added indications for radioactive seed implantation, especially when there are loose tissues in the tumor site, such as a large number of glands in the tumor site, and the implantation site is not suitable for single seed implantation
[0005] The Chinese patent title invented by the inventor is "A Radioactive Particle Chain" and the application publication number is CN103736201A, which proposes a kind of particle chain formed by wrapping hydrophilic alginate as a molding material, which is moist in the body after implantation It can soften quickly in the environment, and finally deform and finally degrade as the tumor tissue shrinks. However, this kind of particle chain lacks sufficient supporting force after softening in the body, so it is only suitable for implantation in tumors with high tissue density. For tumors in cavities and glands, the particle chains are prone to displacement, resulting in dose deviations

Method used

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  • Degradable radioactive particle chain with shape memory function
  • Degradable radioactive particle chain with shape memory function
  • Degradable radioactive particle chain with shape memory function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Pipe production: Add PCL (molecular weight: 50,000) into the extruder separately to make a pipe with an inner diameter of 0.8mm and a wall thickness of 0.2mm.

[0074] Loading of radioactive particles: 10 particles with an outer diameter of 0.8mm and a length of 4.5mm 125 I Radioactive particles are loaded into the PCL tube in turn, and there is no gap between the particles.

[0075] Molding: put into the 125 The PCL tube of I radioactive particles is heated to 70°C on a heating plate, and the tube wall becomes transparent, then the heating is stopped, and a linear particle chain is formed after cooling.

[0076] The prepared radioactive particle chain was tested, the appearance was linear, the surface was uniform, and it could pass through the No. 18 puncture needle smoothly. The two ends of the radioactive particle chain were placed on two wooden boards, and the middle was suspended. The radioactive particle chain did not occur due to its own weight. The resulting d...

Embodiment 2

[0078] Pipe production: Add PCL (molecular weight 50000), PLA (polylactic acid, molecular weight 5000), acetyl tributyl citrate into the extruder in a weight ratio of 80:19:1, and make it into an inner diameter of 0.8mm and a wall thickness of 0.2 mm tubing.

[0079] Loading of radioactive particles: 10 particles with an outer diameter of 0.8mm and a length of 4.5mm 125 I Radioactive particles are loaded into the PCL tube in turn, and there is no gap between the particles.

[0080] Molding: put into the 125 The PCL tube of I radioactive particles is in the arc-shaped tubular mold, heat the mold at 70° C., stop heating after 20 seconds, and demould after cooling to form arc-shaped particle chains.

[0081] The prepared radioactive particle chain was detected, and the appearance was arc-shaped, with a uniform surface, which could pass through the No. 18 puncture needle smoothly, and the arc-shape was still maintained after passing through the puncture needle. When the radioac...

Embodiment 3

[0083] Production of pipes: Add PCL (molecular weight 50,000), nano-calcium carbonate, and acetyl tributyl citrate into the extruder at a weight ratio of 90:5:5 to make pipes with an inner diameter of 0.8mm and a wall thickness of 1mm.

[0084] Loading of radioactive particles: 20 particles with an outer diameter of 0.8mm and a length of 4.5mm 125 I The radioactive particles are loaded into the PCL tube in turn, with an interval of 2mm between each particle.

[0085] Molding: put into the 125 I The PCL tube of radioactive particles is wound into a spiral shape on a heating rod with a diameter of 10 mm that has been heated to 70 ° C. After the winding is completed, the heating is stopped, and a spiral particle chain is formed after demoulding.

[0086] The prepared radioactive particle chain was tested, the appearance was helical, and the surface was uniform. When the radioactive particle chain was suspended, the deformation of the radioactive particle chain did not occur due ...

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PUM

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Abstract

The invention relates to a radioactive brachytherapy device, particularly relates to a degradable radioactive particle chain with shape memory function. The degradable radioactive particle chain comprises at least one radioactive particle and a coating layer, wherein the radioactive particles are radioactive sources and at least a portion of the radioactive particles is coated with the coating layer. The coating layer material comprises polycaprolactone(PCL). The particle chain made of PCL as the main molding material has the shape memory function, which enables an implanting operation of the particle chain to be simple and can maintain a certain supporting force to lumen and glands, and ensures that the particle chain is implanted without affecting a normal physiological function of the lumen and the glands. Meanwhile, the PCL has the advantages of biodegradability and low melting point.

Description

technical field [0001] The invention relates to a radioactive brachytherapy device, in particular to a degradable radioactive particle chain with shape memory function. Background technique [0002] Malignant tumors have always been a major disease that threatens human health, and interstitial brachytherapy of tumors using radioactive particles is a new technology developed in recent decades. Radioactive particles are a small radioactive source. The radioactive isotope is packed in a titanium tube, and the two ends are welded by laser or electron beam technology to form a sealed source. The size is generally 0.8mm in outer diameter and 4.5mm in length. Nuclides commonly used in radioactive particles are 192 Ir, 198 Au, 169 Y, 131 Cs, 103 Pd and 125 I etc., especially 103 Pd and 125 I. Brachytherapy implants radioactive particles directly into the lesion, and continuously irradiates at close range, destroying the DNA double bond of the tumor cell nucleus, killing or ...

Claims

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Application Information

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IPC IPC(8): A61M36/00
CPCA61N5/1007A61N5/1014
Inventor 张文辉高惠波杨博衍李忠勇
Owner HTA CO LTD
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