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Traditional Chinese medicine preparation with blood fat reducing effect, and preparation method thereof

A traditional Chinese medicine preparation and blood lipid-lowering technology, which can be used in medical preparations, pharmaceutical formulations, drug combinations and other directions containing active ingredients, can solve problems such as rhabdomyolysis, change in bowel habits, disability, etc., and achieve a simple production process, a wide range of raw material sources, Affordable effect

Inactive Publication Date: 2017-06-13
INNER MONGOLIA MEDICAL UNIV
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Problems solved by technology

[0003] At present, these Chinese patent medicines for the treatment of hyperlipidemia have common adverse reactions such as headache, insomnia, transient changes in bowel habits, and nausea. These adverse reactions mostly occur during long-term use, and are generally rare in short-term use
What needs special attention is that if this type of drug is used in combination with the lipid-lowering drug gemfibrozil, more serious problems will often occur. In mild cases, it can lead to liver and kidney function damage, muscle pain, and in severe cases, rhabdomyolysis and renal failure may occur. etc., can even lead to death or permanent disability

Method used

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  • Traditional Chinese medicine preparation with blood fat reducing effect, and preparation method thereof

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preparation example Construction

[0016] The embodiment of the present invention provides a preparation method of a traditional Chinese medicine preparation with hypolipidemic effect, comprising the following steps:

[0017] S1. Weigh the raw materials with the following weights: Hawthorn 100g, Myrobalan and Piper longum 80g each.

[0018] S2, 100g of hawthorn, 80g of myrobalan and longan are dried, pulverized into fine powder, sieved, and set aside;

[0019] S3, add 1560ml of distilled water to the fine powder in step 2, soak to the heart; decoct for 30min, filter, then add 1560ml of distilled water for decoction for 15min, filter, combine the filtrate, concentrate the solvent, and dry it into powder; wherein in step 3 The fine powder is added with pharmaceutically acceptable carriers and / or excipients, and can be made into capsules by adopting traditional preparation techniques.

Embodiment 1

[0021] Materials and Animals:

[0022] 1. Test sample: this compound mixture.

[0023] 2. Experimental animals: 40 Wistar rats, half male and half male, weighing 180-220 cm. Provided by the Animal Center of Inner Mongolia University. Temperature: 21℃-24℃, Humidity: 46%-52%.

[0024] 3. Method: Blood was collected from 100 Wistar rats after 7 days of adaptation in the laboratory, blood lipids were measured, and 72 rats whose blood lipids met the test requirements were screened, randomly divided into 6 groups, 12 rats / group. They are blank control group, high fat model group, positive control group, low, middle and high dose groups of compound mixture. After continuous feeding for 35 days, the blank group freely ingested basal feed and administered 2ml / 200g of normal saline every day; the high-fat model group freely ingested high-fat feed and administered 2ml / 200g of normal saline every day; Simvastatin was administered orally, 0.2mg / 200g; the compound mixture low, medium an...

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Abstract

The invention discloses a traditional Chinese medicine preparation with a blood fat reducing effect, and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following raw materials in weight proportion: 100 g of hawthorn, 80 g of myrobalan and 80 g of fructus piperis longi. The traditional Chinese medicine preparation does not have any additives, adopts the prescription with the characteristics of wide raw material source, moderate price and simple and convenient production process, and is non-toxic, non-irritant, remarkable in curative effect and small in side effect; and the traditional Chinese medicine preparation contains natural traditional Chinese medicine blood fat reducing components, effectively inhibits damage of low-density lipoprotein (LDL) on human umbilical vein endothelial cells (EC), reduces release of lactic dehydrogenase (LDH) in the cells and low-density lipoprotein lipid peroxidation (TBARS) value, can directly acts on the EC, reduces the normal adhesion rate of the EC, effectively protects the EC from being damaged by LDL, and reduces the occurrence dangerousness of AS.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine preparation with hypolipidemic effect and a preparation method thereof. Background technique [0002] In the 21st century, people's living standards have been significantly improved, and at the same time some lifestyle-related diseases have become the primary cause of threats to human health. The mortality rate of cardiovascular and cerebrovascular diseases in our country has risen to the second place. Hyperlipidemia, that is, the increase of serum total cholesterol, triglyceride, and low-density lipoprotein is a major cause of cardiovascular and cerebrovascular diseases. A large number of epidemiological surveys and studies have shown that hyperlipidemia is an important risk factor for many diseases such as atherosclerosis (AS), coronary heart disease (CHD), hypertension, diabetes, and cholelithiasis, which seriously endang...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61K9/48A61P3/06
CPCA61K9/4841A61K36/185A61K36/67A61K36/734A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 常福厚
Owner INNER MONGOLIA MEDICAL UNIV
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