Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical formulations for oral delivery of peptide or protein drugs

A protein and drug dosage form technology, applied in the fields of peptide/protein composition, drug combination, drug delivery, etc., can solve the problems that have not been raised

Inactive Publication Date: 2017-05-31
CYPRUMED GMBH
View PDF35 Cites 23 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of copper and ascorbic acid in pharmaceutical compositions, let alone the oral delivery of peptide or protein drugs, has never been proposed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical formulations for oral delivery of peptide or protein drugs
  • Pharmaceutical formulations for oral delivery of peptide or protein drugs
  • Pharmaceutical formulations for oral delivery of peptide or protein drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0189] 1. A peptide or protein drug for use as a medicament having a molecular weight equal to or less than about 50 kDa, wherein the peptide or protein drug is orally administered in combination with:

[0190] A pharmaceutically acceptable copper salt / complex and / or a pharmaceutically acceptable zinc salt / complex; and

[0191] A pharmaceutically acceptable reducing agent.

[0192] 2. A pharmaceutically acceptable copper salt / complex for therapeutic use, wherein said copper salt / complex is administered orally in combination with:

[0193] a pharmaceutically acceptable reducing agent; and

[0194] Peptide or protein drugs having a molecular weight equal to or less than about 50 kDa.

[0195] 3. A pharmaceutically acceptable zinc salt / complex for therapeutic use, wherein said zinc salt / complex is administered orally in combination with:

[0196] a pharmaceutically acceptable reducing agent; and

[0197] Peptide or protein drugs having a molecular weight equal to or less than...

Embodiment 1

[0278] Example 1 : Compatibility of absorption enhancer with trace element copper

[0279] About them and the two main oxidation states of Cu 2+ and Cu + Compatibility Screening of Multiple Absorption Enhancers for the Trace Element Copper. The results of this test are shown in Table 1 below:

[0280]

[0281]

[0282] Table 1: Various absorption enhancers and Cu2 + and Cu + Salt Compatibility

[0283] The term clear solution as used in this table means that no significant visible precipitation or flocculation was observed. The term clear solution also includes slightly colored clear solutions such as yellowish or orange solutions.

[0284] Conclusions: Certain absorption enhancers such as medium chain fatty acid salts and derivatives are not well compatible with copper(II) salts. However, zwitterionic as well as nonionic surfactants show good compatibility with copper salts. In addition, monovalent copper also shows compatibility with sodium caprate and sodium...

Embodiment 2

[0285] Example 2 : Pharmacodynamic and Pharmacokinetic Profiles of Human Insulin Preparations After Administration to the Middle Jejunum of Sprague Dawley Rats

[0286] Method - Administration to Rat Jejunum: Direct application of peptide or protein drugs and their formulations in the mid-jejunum (middle part of the small intestine - the jejunum) enables the study of their passage through the intestinal barrier and resistance to degradation by digestive enzymes Ability. Sprague-Dawley rats weighing 250-300 g were used. The study was performed under anesthesia. The results obtained are shown in Table 2 below:

[0287]

[0288] Table 2: Pharmacokinetic profiles of human insulin preparations

[0289] Conclusions: A simple physical blend of human insulin and the typical absorption enhancer sodium caprate in the presence of the trace element copper and ascorbate as a reducing agent moderately improves the oral bioavailability of human insulin. No more significant improveme...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to View More

Abstract

The present invention relates to improved pharmaceutical formulations, uses and methods for the oral delivery of peptide or protein drugs with advantageously high bioavailability, safety and cost-effectiveness. In particular, the invention provides a peptide or protein drug having a molecular weight of equal to or less than about 50 kDa for use as a medicament, wherein said peptide or protein drug is to be administered orally in combination with a pharmaceutically acceptable copper salt / complex and / or a pharmaceutically acceptable zinc salt / complex, and with a pharmaceutically acceptable reducing agent. The invention also provides a pharmaceutical composition comprising a peptide or protein drug having a molecular weight of equal to or less than about 50 kDa; a pharmaceutically acceptable copper salt / complex and / or a pharmaceutically acceptable zinc salt / complex; and a pharmaceutically acceptable reducing agent.

Description

technical field [0001] The present invention relates to improved pharmaceutical formulations, uses and methods for the oral delivery of peptide or protein drugs with advantageously high bioavailability, safety and cost-effectiveness. Specifically, the present invention provides a peptide or protein drug having a molecular weight equal to or less than about 50 kDa for use as a medicament, wherein, with a pharmaceutically acceptable copper salt / complex (complex) and / or a pharmaceutically acceptable zinc The peptide or protein drug is administered orally in combination with a salt / complex and in combination with a pharmaceutically acceptable reducing agent. The present invention also provides a pharmaceutical composition comprising: a peptide or protein drug having a molecular weight equal to or less than about 50 kDa; a pharmaceutically acceptable copper salt / complex and / or a pharmaceutically acceptable zinc salt / complex; and A pharmaceutically acceptable reducing agent. Back...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K47/12A61K9/48A61K38/28A61P3/10A61K38/08A61K38/095
CPCA61K9/4808A61K38/28A61K47/02A61K47/12A61K38/095A61K38/08A61K38/09A61K38/14A61K38/26A61K38/27A61K38/29A61P3/10A61K9/0053A61K9/485A61K9/4858A61K9/4866A61K47/18A61K47/183A61K47/186A61K47/20A61K47/26A61K47/40A61K47/44
Inventor 弗洛里安·福格尔
Owner CYPRUMED GMBH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com