Preparation method and application of small-molecule panax notoginseng polysaccharide extract
A technology of notoginseng polysaccharides and small molecules, which is applied in the field of extraction and separation of plant active substances, can solve the problems of low drug activity, low utilization of macromolecular polysaccharides, and difficult absorption, and achieve high pharmacological activity, low starch residue, and industrialization. high degree of effect
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Embodiment 1
[0026] Example 1: The preparation method of the small molecule Panax notoginseng polysaccharide extract is as follows:
[0027] (1) Add 95% ethanol solution of 5 times the mass percentage concentration to the pulverized 1kg Panax notoginseng powder for extraction for 3 hours, filter the filter residue and repeat the extraction twice, discard the filtrate to obtain the medicinal residue;
[0028] (2) Add water 8 times the mass of the dregs to the dregs in step (1) and extract twice at 90-93°C. After 2 hours of extraction, filter to obtain the filtrate and discard the dregs;
[0029] (3) Place the filtrate of step (2) at 40°C and concentrate it in vacuum to a Baume degree of 1.1, then add absolute ethanol so that the ethanol concentration in the mixture is 93%, let it stand for 3 hours, and filter to obtain a precipitate;
[0030] (4) Dissolve the precipitate in step (3) with pure water 12 times its mass, then add trifluoroacetic acid with a mass of 4% of the mixed solution, and...
Embodiment 2
[0035] Embodiment 2: The preparation method of the small molecule Panax notoginseng polysaccharide extract is as follows:
[0036] (1) Add 4 times the mass of absolute ethanol to the pulverized 1kg Panax notoginseng powder for extraction for 2 hours, filter the filter residue and repeat the extraction once, discard the filtrate to obtain the medicinal residue;
[0037] (2) Add water 7 times the mass of the dregs to the dregs of step (1) and extract twice at 90-93°C. After 1.5 hours of extraction time, filter to obtain the filtrate and discard the dregs;
[0038] (3) Place the filtrate of step (2) at 50°C for vacuum concentration to a Baume degree of 1.1, then add absolute ethanol so that the ethanol concentration in the mixture is 97%, let it stand for 4 hours, and filter to obtain a precipitate;
[0039] (4) Add 10 times the mass of the precipitate in step (3) to dissolve it in purified water, then add 2% lysozyme to the mass of the mixture, hydrolyze at 35°C for 5 hours, hea...
Embodiment 3
[0044] Embodiment 3: The preparation method of the small molecule Panax notoginseng polysaccharide extract is as follows:
[0045] (1) Add 4 times the mass of anhydrous ethanol to the pulverized 1kg Panax notoginseng powder for extraction for 2 hours, filter the filter residue and repeat the extraction once, discard the filtrate to obtain the medicinal residue;
[0046] (2) Add water 6 times the mass of the dregs to the dregs in step (1) and extract once at 90-95°C. After an extraction time of 1.5 hours, filter to obtain the filtrate and discard the dregs;
[0047] (3) Place the filtrate of step (2) at 50°C for vacuum concentration to a Baume degree of 1.1, then add absolute ethanol so that the ethanol concentration in the mixture is 97%, let it stand for 4 hours, and filter to obtain a precipitate;
[0048] (4) Dissolve the precipitate in step (3) with 10 times the mass of pure water, then add trifluoroacetic acid with 3% mass of the mixed solution, seal and hydrolyze at 90°C...
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