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Application of niclosamide ethanolamine salt in prevention and treating of type 2 diabetes nephropathy

A technology for niclosamide ethanolamine salt and type 2 diabetes, which is applied in the application field of preparing medicines for preventing and treating type 2 diabetic nephropathy, can solve the problems of no research report on the prevention and treatment effect of DN, etc. High serum insulin levels, hypoglycemic effect

Active Publication Date: 2017-05-31
SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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  • Application Information

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Problems solved by technology

However, the efficacy of NEN in the prevention and treatment of DN has not been reported yet.

Method used

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  • Application of niclosamide ethanolamine salt in prevention and treating of type 2 diabetes nephropathy
  • Application of niclosamide ethanolamine salt in prevention and treating of type 2 diabetes nephropathy
  • Application of niclosamide ethanolamine salt in prevention and treating of type 2 diabetes nephropathy

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Embodiment Construction

[0021] Embodiments of the present invention will be specifically described below in conjunction with the accompanying drawings.

[0022] Early DN mainly manifests as glomerular hyperfiltration and microalbuminuria, and its pathological changes are mainly glomerular and tubular basement membrane thickening and mesangial matrix increase. The pathogenesis of DN is still unclear, and treatment methods are scarce. The mTOR / 4E-BP1 signaling pathway plays an important role in cell growth and proliferation, and its dysregulation is closely related to cancer, diabetes, cardiovascular and nervous system diseases. Recent studies have shown that the overactivation of this pathway is closely related to the progression of DN. NEN is the ethanolamine salt form of niclosamide, which is mainly used for anti-parasitic infections. Recent studies have shown that this type of drug also has obvious anti-tumor effects. However, there is no research report on the efficacy of NEN in the prevention an...

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Abstract

The invention relates to a novel application of a niclosamide ethanolamine salt and particularly relates to an application of a niclosamide ethanolamine salt in prevention and treating of type 2 diabetes nephropathy. The protection action and the action mechanism of the niclosamide ethanolamine salt on the type 2 diabetes nephropathy are researched. The result shows that the urinary albumin excretion rate of type 2 diabetes mellitus db / db rats can be reduced by the niclosamide ethanolamine salt, polydipsia and hyperuresis are improved, blood sugar, glycosylated hemoglobin and urine sugar level are reduced, the serum insulin level is improved and the pathological damage of pancreas is improved. By using the niclosamide ethanolamine salt, the pathological damage of glomerulus and kidney tubules can be improved, excretion of urine NAG, NGAL and TGF-beta1 is reduced and activation of a renal cortex mTOR / 4E-BP1 signal channel is inhibited. In addition, the niclosamide ethanolamine salt has a certain protecting effect on liver. In conclusion, the niclosamide ethanolamine salt has a certain protecting effect on type 2 diabetes nephropathy, and the action mechanism is related to inhibition of the mTOR / 4E-BP1 signal channel.

Description

technical field [0001] The present invention relates to a new application of Niclosamide ethanolamine salt (NEN), more specifically, relates to the application of NEN in the preparation of drugs for preventing and treating type 2 diabetic nephropathy. Background technique [0002] Diabetic nephropathy (DN) is one of the most important microvascular complications of diabetes. With the rising incidence of diabetes, DN has surpassed glomerulonephritis-associated chronic kidney disease (CKD) and has become the leading cause of CKD . The onset of DN is insidious, and once it enters the stage of massive proteinuria, it will soon progress to end stage renal disease (ESRD). The main clinical manifestations of early DN are glomerular hyperfiltration and microalbuminuria. Renal hypertrophy is the main pathological feature at this stage, mainly manifested as glomerular hypertrophy, glomerular and tubular basement membrane thickening, and mesangial areas. Extracellular matrix depositi...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61P13/12A61P3/10
CPCA61K31/167
Inventor 孙惠力杜蘅韩鹏勋邵牧民郭岚
Owner SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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