Method for manufacturing aortic intervention valve

Abstract

The invention relates to an implantable intravascular arterial intervention valve and discloses a method for manufacturing an aortic intervention valve. The method includes the following steps that 1, iPSCs are directionally induced in vitro to be differentiated into valves VICs and precursor cells VECs; 2, porcine aortic valves are selected, and enzymes and a detergent are used for removing original valve cells; 3, a protein power processing method is applied to build a core-shell structure fiber-state drug control release system; 4, constructing a skin-core structure superfine composite yarn; 5, the cell-valve-free matrix micro-morphology is processed and modified by plasma etching; 6, positioning is conducted through 3D printing cells, and the controlled release of the drug concentration gradient is conducted. By adopting a nickel-titanium alloy wire material weaving and shaping method, a nickel-titanium alloy support is produced. The automatic control performance of the support is achieved, the optimal stress state of aortic valves of the human body is achieved. The enzymes and the detergent are used for removing valve cells attached to the original aortic valves, cell matrixes are completely preserved, and thus the durability and the anti-calcification property of a product are improved.

Description

technical field [0001] The invention relates to an implantable intravascular arterial interventional valve, especially a manufacturing method for an aortic interventional valve. Background technique [0002] Aortic stenosis is a common senile degenerative heart valve disease, and its incidence gradually increases with age. The incidence of AS in the elderly population over 75 years old is as high as 4.6%. Transcatheter aortic valve implantation is a brand-new minimally invasive valve replacement technology developed in recent years. With its gradual clinical application, it may become one of the main methods for the treatment of severe AS. In the prior art, the aortic interventional valve cannot better adapt to the aortic blood flow, and has the defects of poor durability and anti-calcification performance. Contents of the invention [0003] For the defects existing in the above-mentioned background technology, the technical scheme of the present invention is as follows: ...

AI Technical Summary

Problems solved by technology

In the prior art, the aortic interventional valve cannot better adapt to the aortic blood flow, and has the defects of poor durability and anti-calcification performance

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