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Rhein supramolecular hydrogel as well as preparation method and application thereof

A technology of supramolecular hydrogel and rhein, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of poor solubility and short half-life of rhein, and achieve biological activity retention and preparation Simple process and enhanced therapeutic effect

Active Publication Date: 2017-05-24
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to overcome the deficiencies of the prior art, provide a rhein supramolecular hydrogel with anti-inflammatory, antibacterial, anti-tumor properties, which can solve the problems of poor solubility and short half-life of rhein, and Preserves the biological activity of rhein

Method used

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  • Rhein supramolecular hydrogel as well as preparation method and application thereof
  • Rhein supramolecular hydrogel as well as preparation method and application thereof
  • Rhein supramolecular hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A kind of rhein supramolecular hydrogel of the present invention comprises rhein and NaHCO 3 solution, rhein dissolved in NaHCO 3 solution, prepared by the following preparation method:

[0033] (1) Weigh 1.68 g NaHCO 3 In a beaker, add ultrapure water and stir to dissolve, then transfer to a 100 mL volumetric flask, add water to volume, and prepare NaHCO with a concentration of 0.2 mol / L 3 solution.

[0034] (2) Weigh 1 mg, 2 mg, and 6 mg of rhein into corresponding screw-top bottles, and add 1 mL of NaHCO with a concentration of 0.2 mol / L to each screw-top bottle while shaking. 3 The solution was then ultrasonically dispersed for 30 min at an ultrasonic power of 100 W, and the temperature did not exceed 37 °C, and 1 mg / mL and 2 mg / mL rhein solutions and 6 mg / mL rhein supramolecular hydrogels were prepared respectively.

[0035] 1 mg / mL, 2 mg / mL rhein solution and 6 mg / mL rhein supramolecular hydrogel were scanned by electron microscope.

[0036] Experimental step...

Embodiment 2

[0041] A kind of rhein supramolecular hydrogel of the present invention comprises rhein and NaHCO 3 solution, rhein dissolved in NaHCO 3 solution, prepared by the following preparation method:

[0042] (1) Weigh 1.68 g NaHCO 3 In a beaker, add ultrapure water and stir to dissolve, then transfer to a 100 mL volumetric flask, add water to volume, and prepare NaHCO with a concentration of 0.2 mol / L 3 solution.

[0043] (2) Weigh 4 mg and 5 mg of rhein into screw-top bottles respectively, and add 1 mL of NaHCO from step (1) into the screw-top bottles while vibrating 3 The solution was then ultrasonically dispersed for 30 min with an ultrasonic power of 70W, and the temperature did not exceed 37°C to prepare a 4 mg / mL rhein solution and a 5 mg / mL rhein supramolecular hydrogel.

[0044] A digital camera was used to record the appearance of the rhein solution and the rhein supramolecular hydrogel. image 3 Among them, (a) is a digital photo of rhein solution, and (b) is a digital ...

Embodiment 3

[0048] A kind of rhein supramolecular hydrogel of the present invention comprises rhein and NaHCO 3 solution, rhein dissolved in NaHCO 3 solution, prepared by the following method:

[0049] (1) Weigh 1.68 g NaHCO 3 In a beaker, add ultrapure water and stir to dissolve, then transfer to a 100 mL volumetric flask, add water to volume, and prepare NaHCO with a concentration of 0.2 mol / L 3 solution.

[0050] (2) Weigh 5 mg, 6 mg, 7 mg and 8 mg of rhein into corresponding screw-top bottles, and add 1 mL of NaHCO in Example 1 to the screw-top bottles while vibrating 3 The solution was ultrasonically dispersed at an ultrasonic power of 100 W for 30 min, and the temperature could not exceed 37 °C, and 5 mg / mL, 6 mg / mL, 7 mg / mL and 8 mg / mL rhein supramolecular hydrogels were prepared respectively.

[0051] The 5 mg / mL, 6 mg / mL, 7 mg / mL and 8 mg / mL rhein supramolecular hydrogels in this example were subjected to ultraviolet tests.

[0052] Test results such as Figure 4 As shown, ...

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Abstract

The invention discloses a rhein supramolecular hydrogel as well as a preparation method and application thereof. The rhein supramolecular hydrogel comprises rhein and a N3HCO3 solution, wherein the rhein is dissolved into the N3HCO3 solution. The preparation method comprises the following steps: dissolving the rhein into the N3HCO3 solution, and performing ultrasonic dispersion, so as to obtain the rhein supramolecular hydrogel. The rhein supramolecular hydrogel has the characteristics of anti-inflammatory property, antibacterial property and antineoplastic property, can solve the problems of poor solubility and short half-life period of rhein, reserves the biological activity of the rhein, and has obvious treatment effect on the application of medicines for treating microglial cell mediated inflammatory encephalopathy, such as Alzheimer disease, Parkinson disease, cerebral trauma and cerebral edema.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a preparation method and application of a rhein supramolecular hydrogel. Background technique [0002] Rhein is a free anthraquinone substance derived from the traditional Chinese medicine rhubarb, and its molecular formula is CH 15 h 8 o 6 . Rhein is a natural antioxidant and anti-inflammatory substance, with less toxic and side effects, and has good antioxidant and anti-inflammatory effects, so it is used in anti-tumor, anti-inflammatory, purgative, neuroprotective, lipid-lowering, etc. have higher activity. [0003] Microglia, as a kind of central nervous system glial cell, is the main effector cell involved in the immune and inflammatory response of the brain. In Alzheimer's disease, Parkinson's disease, traumatic brain injury, cerebral edema and other microglia-mediated inflammatory diseases, when the central nervous system is damaged, resting micro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/192A61K47/02A61P29/00A61P25/00A61P25/28A61P25/16A61P7/10
CPCA61K9/06A61K31/192A61K47/02
Inventor 王杨张翼郑俊郑飘唐涛范学工范荣
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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