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Synbiotics and preparation method thereof

A technology of synbiotics and probiotics, applied in the field of health food, can solve problems such as poor effect, and achieve the effect of low cost, easy industrial promotion, and simple process

Inactive Publication Date: 2017-05-24
南京布莱捷生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a kind of synbiotic to solve the problem that the existing products are not effective in regulating the human intestinal flora and bidirectionally regulating constipation and diarrhea

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 synbiotics

[0021] Weigh 3200g of galacto-oligosaccharides, 700g of xylo-oligosaccharides, and 100g of fructo-oligosaccharides, mix them with a mixer for 15 minutes, and mix them uniformly; After drying for 6 hours, control the moisture content below 5%, then pass through a 100-mesh sieve, add probiotics (3.5g of Lactobacillus acidophilus, 3.5g of Bifidobacterium longum, 10.5g of Lactobacillus paracasei, milk of rhamnose Bacillus 14g, Lactobacillus fermentum 7g, Streptococcus thermophilus 21g, Lactobacillus helveticus 10.5g) 70g, mix again evenly, use automatic filling machine to pack into 1000 bags, operating room temperature 18~25℃, relative humidity below 40% .

[0022] When taking, the product of the present invention is mixed with warm boiled water below 50°C or directly added to milk, fruit juice and other liquid foods for consumption.

Embodiment 2

[0024] Animal experiments: the effect of the product of the present invention on regulating intestinal flora

[0025] The animal experiments were carried out with reference to the "test method for regulating the function of intestinal flora" in the functional evaluation test method of "Technical Specifications for Health Food Testing and Evaluation".

[0026] Select ICR male mice, 18-22g, 10 in each group. A blank control group and a test group were set up, and the test samples were administered for 14 days. Before administering the test sample, 0.1 g of mouse feces was aseptically collected, serially diluted 10 times, and an appropriate dilution was selected to inoculate on each culture medium. After culturing, identify and count the colonies by colony morphology, Gram staining microscope, biochemical reaction, etc., calculate the number of bacteria per gram of wet stool, and perform statistical processing after taking the logarithm. 24 hours after the last administration o...

Embodiment 3

[0029] Animal experiments: the effect of the product of the present invention on improving constipation

[0030] Select 40 ICR mice, half male and half male, clean grade. They were randomly divided into 4 groups, 10 rats in each group, and a test group and a blank control group were set up. Oral administration of compound diphenoxylate (10mg / kg) caused constipation model. After gavage of diphenoxylate for 1 hour, the synbiotic prepared in Example 1 was fed. After feeding, the animals in each group were placed in a bell jar covered with filter paper for observation, and each animal was placed alone, and the time and number of black stools discharged by the mice for the first time within 6 hours were recorded, and the weight was weighed; the feces were dried, and the content of the feces was calculated. Water volume (%) [(wet stool mass-dry stool mass) / wet stool mass×100%)]

[0031] The first defecation time of mice fed with synbiotics (140.5±17.3min) was significantly lower ...

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PUM

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Abstract

The invention discloses synbiotics comprising prebiotics and probiotics; the prebiotics are a combination of arbitrary one or more of galactooligosaccharide, xylooligosaccharide and oligofructose; the probiotics are a combination of arbitrary one or more of lactobacillus acidophilus, bifidobacterium longum, lactobacillus paracasei, lactobacillus rhamnosus, lactobacillus fermentium, streptococcus thermophilus and lactobacillus helveticus. The invention also discloses a preparation method of the synbiotics. Compared with the prior art, the synbiotics can effectively adjust intestinal flora of a human body, can adjust constipation and diarrhea in a dual-directional manner, and cannot produce drug dependence. Meanwhile, the method has the advantages of simple process, low cost and easy industrial promotion.

Description

technical field [0001] The invention belongs to the technical field of health food, and in particular relates to a synbiotic and a preparation method thereof. Background technique [0002] In recent years, with the increasingly serious environmental pollution, accelerated pace of life, changes in diet structure, and increased mental and social pressure, functional intestinal diseases such as constipation and constipation have become one of the main problems plaguing modern people. affect people's quality of life. Functional constipation refers to primary persistent constipation caused by non-systemic diseases or intestinal diseases. The traditional medicine for treating constipation is laxatives, which can quickly relieve constipation symptoms, but damage the spleen and stomach and cannot solve the fundamental problem. Functional diarrhea generally refers to diarrhea caused by motility disorders of the gastrointestinal tract. [0003] At present, for diarrhea or constipati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/09A23L1/30
Inventor 王平王晓萍任增良
Owner 南京布莱捷生物科技有限公司
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