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Preparation method of high-purity garlic trithiodipropylene

A technology for trithiodipropylene and trithiodipropylene oil, which is applied in the field of preparation of high-purity garlic trithiopropylene, can solve the problems of low purity of garlic trisulfide and not suitable for medical use, and achieves the effect of reducing the content

Active Publication Date: 2017-05-10
HENAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The invention proposes a method for preparing high-purity garlic trithiodipropylene, which solves the problems of low purity of garlic trithiodipropylene, unsuitability for medical use, removal of garlic dithiodipropylene and other impurities, and the prepared product does not contain methanol residues

Method used

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  • Preparation method of high-purity garlic trithiodipropylene

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Embodiment 1

[0026] In the present embodiment, the preparation method of high-purity garlic trithiodipropylene is as follows:

[0027] (1) Garlic is peeled and crushed, placed in the air for 10 minutes, the garlic oil is extracted by steam distillation technology, the crushed garlic is directly mixed with three times the mass of water, heated to boiling with a volatile oil extraction device, the garlic volatile oil is collected, and distilled The time is 30 minutes;

[0028] (2) Add the garlic volatile oil in step (1) to C 18 In the chromatographic column, it is eluted with a methanol-water solution of 60% by volume to obtain a methanol-water solution of garlic trithiodipropylene;

[0029] (3) the purity of the methanol-water solution of garlic trithiodipropylene obtained in the HPLC method detection step (2), the methanol-water solution of garlic trithiodipropylene with a purity greater than 90% is collected; the detected purity is low Collect in addition the methanol-water solution of ...

Embodiment 2

[0036] In the present embodiment, the preparation method of high-purity garlic trithiodipropylene is as follows:

[0037] (1) Garlic is peeled and crushed, placed in the air for 12 minutes, the garlic oil is extracted by steam distillation technology, the crushed garlic is directly mixed with three times the mass of water, heated to boiling with a volatile oil extraction device, the garlic volatile oil is collected, and distilled The time is 40 minutes;

[0038] (2) Add the garlic volatile oil in step (1) to C 8 In the chromatographic column, the methanol-water solution with a volume ratio of 80% is eluted to obtain the methanol-water solution of garlic trithiodipropylene;

[0039] (3) the purity of the methanol-water solution of garlic trithiodipropylene obtained in the HPLC method detection step (2), the methanol-water solution of garlic trithiodipropylene with a purity greater than 90% is collected; the detected purity is low Collect in addition the methanol-water solutio...

Embodiment 3

[0045] In the present embodiment, the preparation method of high-purity garlic trithiodipropylene is as follows:

[0046] (1) Garlic is peeled and crushed, placed in the air for 15 minutes, the garlic oil is extracted by steam distillation technology, the crushed garlic is directly mixed with three times the mass of water, heated to boiling with a volatile oil extraction device, the garlic volatile oil is collected, and distilled The time is 45 minutes;

[0047] (2) Add the garlic oil in step (1) to C 18 In the chromatographic column, the methanol-water solution with a volume ratio of 90% is eluted to obtain the methanol-water solution of trithiodipropylene;

[0048] (3) the purity of the methanol-water solution of garlic trithiodipropylene obtained in the HPLC method detection step (2), the methanol-water solution of garlic trithiodipropylene with a purity greater than 90% is collected; the detected purity is low Collect in addition the methanol-water solution of 90% trithi...

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Abstract

The invention provides a preparation method of high-purity garlic trithiodipropylene. The method comprises the following steps that garlic is peeled and crushed, and is put into the air for 10 to 15 minutes; the garlic volatile oil is extracted by a wet distillation technology; the garlic volatile oil is added into a C18 or C8 chromatographic column, and is eluted by a methyl alcohol-water solution to obtain a methyl alcohol-water solution of the garlic trithiodipropylene; the methyl alcohol-water solution of the garlic trithiodipropylene with the purity being greater than 90 percent is collected; the collected methyl alcohol-water solution of the garlic trithiodipropylene is extracted in three times by injection soybean oil or corn oil; garlic trithiodipropylene oil solution is obtained; the garlic trithiodipropylene oil solution is extracted by water; the extraction is performed for three times; the methyl-alcohol-free garlic trithiodipropylene oil solution is obtained. The method has the advantages that the natural garlic oil with high purity can be provided for oil injection or other preparations. The method provided by the invention is also suitable for the removal of the chloropropene removal from the garlic trithiodipropylene, and the high-purity trithiodipropylene prepared by the method is suitable for medical use.

Description

technical field [0001] The invention relates to the field of methods for purifying garlic oil, in particular to a method for preparing high-purity garlic trithiodipropylene. Background technique [0002] Garlic trithiodipropylene is the main active ingredient of garlic, derived from the plant Allium genus Garlic ( Allium sativum L ) underground bulbs. Its bactericidal effect is the strongest among higher plants, and it can kill many pathogenic bacteria and parasites in the human body. It is called "natural penicillin" in Western Europe; it has a strong anti-cancer effect; it can also increase the content of insulin in plasma , lower blood sugar levels, known as plant gold by scientists. Allicin injection is one of the high-risk varieties notified by the State Food and Drug Administration, and the unsafe factors mainly contain easily degradable impurities such as dithiodipropylene; industrial production also synthesizes garlic trithiodipropylene, but among them Impuritie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C319/28C07C321/18
CPCC07C319/28C07C321/18
Inventor 王先友胡海廷袁琦郝喜才李禄辉程浩
Owner HENAN UNIVERSITY
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