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Oral desloratadine drops and preparation method thereof

A technology of desloratadine and oral drops, which is applied in the field of pharmacy, can solve the problems of inaccurate and unhygienic dosage, and achieve the effect of scientific and reasonable dosage, easy acceptance and good taste

Inactive Publication Date: 2017-05-10
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem of inaccurate or unhygienic dosage of desloratadine syrup or solution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] prescription:

[0015] Desloratadine 0.25g;

[0016] Citric acid 1.50g;

[0017] Sodium citrate 10g;

[0018] Edetate Disodium 0.25g;

[0019] Sodium Benzoate 0.5g;

[0020] Sorbitol 5g;

[0021] Glycerin 40g;

[0022] Lemon essence 1.5g;

[0023] 325g of sucrose;

[0024] FDC yellow 6 0.05g;

[0025] Add pure water to 500ml.

[0026] Preparation Process:

[0027] 1. Crushing the raw material desloratadine, sucrose, citric acid, etc. through a 100-mesh sieve for later use;

[0028] 2. Weigh 250g of purified water in a beaker, boil, add 325g of sucrose, heat until dissolved, then add 1.50g of citric acid, 10g of sodium citrate, 0.5g of sodium benzoate, 5g of sorbitol and stir until dissolved, then cool to room temperature, form a syrup;

[0029] 3. Weigh 2g of boiled purified water, add the prescribed amount of edetate disodium, stir until dissolved, then add to the syrup formed in step 2, and stir evenly;

[0030] 4. Weigh 0.25g of desloratadine raw materi...

Embodiment 2

[0036] prescription:

[0037] Desloratadine 0.25g;

[0038] Citric acid 1.5g;

[0039] Sodium citrate 10g;

[0040] Edetate Disodium 0.25g;

[0041] Sodium Benzoate 0.5g;

[0042] Sorbitol 5g;

[0043] Ethanol 10ml;

[0044] Propylene glycol 40g;

[0045] Strawberry essence 2.0g;

[0046] 325g of sucrose;

[0047] Carmine 0.05g;

[0048] Add pure water to 500ml.

[0049] Preparation Process:

[0050] 1. Crushing the raw material drug desloratadine, sucrose, citric acid, etc. through a 100-mesh sieve for later use;

[0051] 2. Weigh 250g of purified water in a beaker, boil, add 325g of sucrose, heat until dissolved, then add 1.50g of citric acid, 10g of sodium citrate, 0.5g of sodium benzoate, 5g of sorbitol and stir until dissolved, then cool to room temperature to form syrup;

[0052] 3. Weigh 2g of boiled purified water, add the prescribed amount of edetate disodium, stir until dissolved, then add to the syrup formed in step 2, and stir evenly;

[0053] 4. We...

Embodiment 3

[0059] prescription:

[0060] Desloratadine 1.0g;

[0061] Citric acid 10.0g;

[0062] Sodium citrate 10.0g;

[0063] Edetate Disodium 0.05g;

[0064] Sodium Benzoate 3.5g;

[0065] Sorbitol 20g;

[0066] Glycerin 50g;

[0067] Strawberry essence 3.0g;

[0068] Lactose 650g;

[0069] Carmine 0.1g;

[0070] Add pure water to 500ml.

[0071] Preparation Process:

[0072] 1. Crushing the raw material desloratadine, lactose, citric acid, etc. through a 100-mesh sieve for later use;

[0073]2. Weigh 300g of purified water in a beaker, boil, add 650g of lactose, heat until dissolved, then add 10.0g of citric acid, 10.0g of sodium citrate, 3.5g of sodium benzoate, 20g of sorbitol and stir until dissolved, then cool to room temperature, form a syrup;

[0074] 3. Weigh 2g of boiled purified water, add the prescribed amount of edetate disodium, stir until dissolved, then add to the syrup formed in step 2, and stir evenly;

[0075] 4. Weigh 0.25g of desloratadine bulk drug...

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Abstract

The invention belongs to the technical field of medicines and relates to a preparation method of oral desloratadine drops. The oral desloratadine drops are prepared from a loratadine raw material medicine, a preservative, a stabilizer, a coloring agent, a corrigent, a thickening agent, a cosolvent and the like. 10 mg of drops is orally taken every time for adults and adolescents of 12 years old or above, and infants are administrated according to kilogram and body weight. The oral desloratadine drops are syrup or a solution and has the following advantages in overall effect that the drug exists in a molecular state in liquid, can be rapidly absorbed after administration, plays a drug action and is high in initial effect time; the process is simple in operation, the cost is low, and the drops are convenient to take, stable in quality, reliable in treating effect and easy to absorb; the drops are good in taste, are conveniently accepted by patients, are suitable for patients difficult to take orally and infant and old diseased patients and has strong anti-inflammatory and antiallergic effects and rapid oral taking and absorbing effects, and the nose and eye symptoms and signs are relieved after the drug is orally taken.

Description

technical field [0001] The invention belongs to the field of pharmacy. The invention is an oral drop of desloratadine. The preparation is convenient to take, scientific and reasonable, convenient to take and quick to take effect. Desloratadine is used as an active ingredient in the oral preparation Treatment of seasonal allergic rhinitis and perennial allergic rhinitis, allergic conjunctivitis, chronic urticaria. Background technique [0002] Desloratadine is the active metabolite of loratadine deformation in vivo. It is a new third-generation antihistamine with strong anti-allergic effect, fast onset and long-lasting effect. It has affinity and selectivity for peripheral H1 receptors, and is a new drug for treating seasonal allergic rhinitis and chronic urticaria. In vitro model experiments on human H1 receptor expression have confirmed that its antagonistic activity is 50-200 times that of loratadine, fexofenadine or cetirizine, and it is safe and effective, with good pa...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K9/08A61K31/4545A61P37/08A61P11/02A61P17/00A61P27/02
CPCA61K9/0095A61K31/4545
Inventor 司俊仁马莉
Owner BEIJING VENTUREPHARM BIOTECH
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