Temperature Sensitive Stem Cell Infusion System

A temperature-sensitive, stem cell technology, applied in sensors, intracranial pressure measurement, medical science, etc., can solve the problems of aggravating the patient's condition, cell adhesion in the spinal canal, and large amount of one-time cell injection, so as to avoid the patient's discomfort Effect

Active Publication Date: 2020-01-21
黑龙江和泽北方生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the existing bone injury treatment methods are surgery, tissue engineering technology, gene therapy rejection method, growth factor, adjuvant therapy of physical therapy, etc., and the patients suffer great injuries and are not easy to recover
Moreover, in the course of stem cell transplantation treatment, if the stem cell transplantation is carried out in a short period of time, it is easy to cause too much cell injection at one time, causing side effects
For example, in the treatment of brain trauma stem cell transplantation, too many stem cells transplanted at one time will cause cell adhesion in the spinal canal, which will block the circulation of cerebrospinal fluid and aggravate the risk of the patient's condition

Method used

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  • Temperature Sensitive Stem Cell Infusion System

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Example 1, each device is connected through a drainage tube to form a system capable of continuous pumping of temperature-sensitive stem cells and treatment of bone injuries (especially brain trauma). The cell heat preservation and suspension device has a heat preservation device and a horizontal rotation device. When the stem cell suspension isolated and cultured from bone marrow or umbilical cord is placed in the cell heat preservation and suspension device, the continuous heat preservation and rotation function of the cell heat preservation and suspension device, It can keep temperature-sensitive stem cells at a constant temperature of 37°C for 12 hours, and rotate horizontally at an appropriate speed to prevent stem cells from adhering to the wall, adhering to each other and forming a group, and maintaining the state of stem cell suspension.

[0036] The cell flow rate can be controlled by observing the display data of the drainage speed display on the shunt device t...

Embodiment 2

[0037] Embodiment 2, for the treatment of bone injuries, such as bone joint cavity, femoral head necrosis, unhealed fracture cavity, etc., the device can be directly connected and installed according to Embodiment 1, and the needle of the lumbar drainage device can be positioned and punctured The bone injury site is injected with temperature-sensitive stem cell suspension for bone injury treatment.

Embodiment 3

[0038] Example 3, for the treatment of brain trauma, the isolated and cultured temperature-sensitive stem cell suspension is injected into the cell heat preservation and suspension device, and the temperature of the cell heat preservation and suspension device is adjusted to maintain at 37°C. The entire system is connected, and the waist The needle of the large pool drainage device punctures the subarachnoid space in the spine, and the cells are infused into the spinal canal at a rate of not higher than 5 cells / second. Each infusion cycle is about 6 to 8 hours, and the completion of not less than 100,000 cells Cell infusion to treat brain trauma.

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Abstract

The invention relates to a pumping system capable of slowly and continuously infusing therapy cells, such as temperature-sensitive stem cells; the system comprises a cell insulation and mixing-suspending device, a dividing device, a cell speed limiter, an antibacterial counter-growth device, a liquid residue collection device, a tee device and a lumbar cistern drainage device. As a thermostat and a rotator are mounted in the cell insulation and mixing-suspending device, the cell insulation and mixing-suspending device is capable of keeping the inside of a container constantly at 37 DEG C continuously for 12 hours; the cell insulation and mixing-suspending device rotates horizontally at suitable speed, wall attaching and mutual adhesion of stem cells are avoided, stem cell suspension state is maintained, and continuous slow infusion of the stem cells is achieved; the rotating speed may be limited to 30 r / min; the system also has sealing and asepsis functions.

Description

technical field [0001] The invention belongs to the technical field of stem cell pumping systems, in particular to a temperature-sensitive stem cell pumping system. Background technique [0002] At present, stem cell transplantation in neurosurgery has become a common treatment method for severe injuries, especially in cases of severe brain trauma. In recent years, the discovery of stem cells has opened up a new treatment method for the treatment of craniocerebral injury. Clinically, lumbar puncture is often used for stem cell transplantation. Stem cells can pass through the blood-brain barrier and reach the brain tissue through the circulation of cerebrospinal fluid. In the "Establishment of temperature-sensitive stem cell line and its experimental study on mild hypothermia treatment of traumatic brain injury" published in "Chinese Journal of Neurosurgery" 2009, 11:1047-1050, Liu Zhenlin and others confirmed that patients with severe brain injury received mild hypothermia t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M31/00A61B5/03A61B10/00
CPCA61B5/031A61B10/0045A61B2010/0077A61M31/00A61M2210/02A61M2210/0693
Inventor 韩宝印
Owner 黑龙江和泽北方生物科技有限公司
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