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Functional patch and preparation method and applications thereof

A functional, patch technology, applied in coating, medical science, filament/wire forming, etc., to achieve good mechanical properties

Inactive Publication Date: 2017-04-26
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the defects of existing artificial tissue scaffolds such as patches, the present invention provides a functional patch with good mechanical properties, anti-adhesion, good biocompatibility, antibacterial, and drug loading

Method used

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  • Functional patch and preparation method and applications thereof
  • Functional patch and preparation method and applications thereof
  • Functional patch and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 PP / PLA / moxifloxacin functional patch

[0036] 1. Dissolve 2.01 g of polylactic acid (PLA) in 20.10 g of dichloromethane and stir until uniform to obtain a polymer solution, then add 0.10 g of moxifloxacin into the polymer solution, and stir until uniform to obtain a mixed solution.

[0037] 2. Take 5mL of the mixed solution prepared in step 1, put it into a container with a spinneret, set up an electrospinning device with an electrostatic voltage of 25kV, and collect it with a flat-plate collecting device with a PP mesh. The flat-plate and -0.5 The kV voltage is connected, the distance between the spinneret and the spinning device is 20cm, the ambient temperature is controlled at 25°C, and the relative humidity of the environment is 57.5%, and the fiber film is obtained by spinning.

[0038] 3. Dissolve 0.45 g of polylactic acid (PLA) in 9.00 g of dichloromethane and stir until uniform to obtain a polymer solution, then add 0.045 g of moxifloxacin to the polym...

Embodiment 2

[0041] Example 2 PP / PLA / ciprofloxacin functional patch

[0042] 1. Dissolve 1.95g of polylactic acid (PLA) in 9.75g of dichloromethane and stir until uniform to obtain a polymer solution, then add 0.098g of ciprofloxacin into the polymer solution, and stir until uniform to obtain a mixed solution.

[0043]2. Take 5mL of the mixed solution prepared in step 1, put it into a container with a spinneret, set up an electrospinning device with an electrostatic voltage of 10kV, and collect it with a flat-plate collecting device with a PP mesh. The flat-plate and -20.0 The kV voltage is connected, the distance between the spinneret and the spinning device is 40cm, the ambient temperature is controlled at 10°C, and the relative humidity of the environment is 25%, and the fiber film is obtained by spinning.

[0044] 3. Dissolve 0.65 polylactic acid (PLA) in 6.50 g of dichloromethane and stir until uniform to obtain a polymer solution, then add 0.13 g of ciprofloxacin into the polymer sol...

Embodiment 3

[0047] Example 3 PP / PLA aspirin functional patch

[0048] 1. Dissolve 0.16g of polylactic acid (PLA) in 16g of dichloromethane and stir until uniform to obtain a polymer solution, then add 0.24g of aspirin into the polymer solution, stir until uniform to obtain a mixed solution.

[0049] 2. Take 5mL of the mixed solution prepared in step 1, put it into a container with a spinneret, set up an electrospinning device with an electrostatic voltage of 10kV, and collect it with a point-to-point wire collection device with a PP mesh. Metal point electrodes and -0.5kV voltage connected, 5cm away from the drum, the drum speed 1525r / min, the distance between the spinneret and the drum is 3cm, the ambient temperature is controlled at 40°C, the relative humidity of the environment is 90%, and the fiber film is obtained by spinning.

[0050] 3. Dissolve 0.25 g of polylactic acid (PLA) in 3.57 g of dichloromethane and stir until uniform to obtain a polymer solution, then add 0.0036 g of asp...

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Abstract

The invention discloses a functional patch and a preparation method and applications thereof. The functional patch comprises a support layer and a functional layer. The support layer is composed of a non-degradable polymer mesh material. The functional layer is composed of a particle attached cellulose membrane. The cellulose membrane and particles are composed of polymers and loads. The cellulose membrane is prepared by an electro-spinning method, and the particles are prepared by an electro-spraying method. Compared with the conventional patches, the patch has the functions of preventing bacteria, eliminating inflammation, reliving pains, preventing adhesion, and promoting wound healing, and can be applied to the fields such as scaffold for tissue engineering, drug-delivery carriers, wound dressing, and the like.

Description

technical field [0001] The invention belongs to the field of polymer materials, and more specifically relates to a functional patch and its preparation method and application. [0002] technical background [0003] A hernia is a symptom in which any organ or tissue leaves its original site and enters another site through normal and abnormal weak points or defects or pores in the human body. At present, the commonly used treatment method is tension-free hernia mesh repair, which is to return the viscera to its original position, then place the mesh at the opening and fix it by suturing or other methods, and close the opening. The advantages of this method are less pain, short recovery period, and low recurrence rate. However, this method may cause adhesion between the patch and viscera, wound infection, etc. after the operation, resulting in pain or even a second operation, bringing both psychological and physical pain to the patient. [0004] At the same time, there are man...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/14A61L31/04D01D5/00
CPCA61L31/042A61L31/14A61L31/16A61L2300/232A61L2300/30A61L2300/404A61L2300/41A61L2300/414D01D5/0015D01D5/0084C08L5/08
Inventor 王林格李牧甘展慧贾毅凡孔得宇汤强强
Owner SOUTH CHINA UNIV OF TECH
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