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Urinary protein markers of breast cancer and their use in diagnosis and prognosis

A breast cancer, protein technology, applied in the field of clinical medicine

Active Publication Date: 2018-11-06
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the diagnostic technology of breast cancer has been continuously developed in recent years, there are still many patients who cannot be diagnosed in the early stage of breast cancer with the existing diagnostic technology

Method used

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  • Urinary protein markers of breast cancer and their use in diagnosis and prognosis
  • Urinary protein markers of breast cancer and their use in diagnosis and prognosis
  • Urinary protein markers of breast cancer and their use in diagnosis and prognosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1. Establishment of tumor animal models

[0067] 1. The walker256 rat tumor model is a classic animal model for studying tumor progression or tumor cachexia, and is suitable for studying pathophysiological and morphological changes during tumor progression.

[0068] Using this animal model to simulate the pathogenesis of tumors and observe the overall changes of tumors from normal, early tumors, tumor progression and advanced tumor cachexia is of great importance for clinical early diagnosis of breast cancer, monitoring of breast cancer progression, and diagnosis of advanced tumor cachexia. Guiding significance.

[0069] 2. Materials and Reagents

[0070] 1) Instrument:

[0071] Rat metabolic cage: purchased from Beijing Jiayuan Xingye Technology Co., Ltd.

[0072] Thermo-Orbitrap Lumos was purchased from Thermo Corporation.

[0073] 2) Main reagents:

[0074] Deionized water was from MillliQ RG ultrapure water system; chromatographic grade acetonitrile, fo...

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Abstract

The invention relates to a urine protein marker of breast cancer and applications thereof in diagnosis and prognosis. Specifically, the invention relates to applications of the urine protein marker of breast cancer in early diagnosis and disease monitoring of human breast cancer. The urine protein marker comprises beta-2 microglobulin, alpha-1-acid glycoprotein 1, programmed cell death 6 interacting protein, haptoglobin related protein, addiment C4-A, apolipoprotein A-IV, calcium binding protein, HLA-I histocompatibility antigen, A-3 alpha chain, pancreatic stone protein 1 alpha, blood coagulation factor XII, collectin 12, galectin-3 binding protein, vitamin D binding protein, and the like.

Description

technical field [0001] The invention relates to clinical medicine; in particular, it relates to urine protein markers related to human breast cancer. Specifically, the present invention relates to urine protein markers related to the diagnosis and / or monitoring of human breast cancer obtained by using a breast cancer rat disease model and mass spectrometry proteomics technology, and uses thereof. Background technique [0002] Disease biomarkers are measurable changes associated with specific pathological processes, which are used to diagnose diseases, monitor disease course, predict disease prognosis, and evaluate treatment effects, etc. [0003] Urine is an ideal source of disease markers, which can be obtained in large quantities in a non-invasive manner; more importantly, there is no regulation of homeostasis mechanisms in urine, so urine can enrich various changes excreted in the body, and these Changes are potential disease markers. At the same time, the lack of homeo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574G01N33/68G01N33/573
CPCG01N33/573G01N33/5735G01N33/57415G01N33/57488G01N33/68G01N33/6854G01N2800/56G01N2800/60
Inventor 高友鹤吴建强
Owner BEIJING NORMAL UNIVERSITY
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