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A kind of quality standard detection method of 20(r)-ginsenoside rg3

A quality inspection method and ginsenoside technology are applied in the field of quality inspection of 20-ginsenoside Rg3 raw materials, and can solve the problems that the safety and controllability of 20-(R)-ginsenoside Rg3 cannot be satisfied.

Active Publication Date: 2018-11-23
富力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] With people's increasing requirements for the quality of medicines, the existing 20-(R)-ginsenoside Rg3 quality detection methods are only for qualitative identification, quantitative detection and some physical and chemical detection, which cannot meet people's requirements for 20-(R) )-Requirements for the safety and controllability of ginsenoside Rg3

Method used

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  • A kind of quality standard detection method of 20(r)-ginsenoside rg3
  • A kind of quality standard detection method of 20(r)-ginsenoside rg3
  • A kind of quality standard detection method of 20(r)-ginsenoside rg3

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Experimental program
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Effect test

Embodiment 1

[0321] The preparation of embodiment 1 crude drug 20 (R)-ginsenoside Rg3

[0322] Cultivated ginseng coarse powder 500g, extracted three times with hot water at 80°C, each time with 4000ml of hot water, leached for 4 hours each time; combined the extracts, filtered; concentrated the extracts to 2500ml, extracted 5 times with an equal volume of n-butanol , combine the extracts; concentrate the extracts to dryness, dissolve with 1000ml water, filter; the filtrate passes through a macroporous adsorption resin column, elutes with water, 30% ethanol, and 50% ethanol successively, and collects 50% ethanol fractions; concentrates, uses 500ml of 80% ethanol was recrystallized three times, and the resulting precipitate was dried and pulverized to obtain about 2.2g of 20(R)-ginsenoside Rg3. The raw material drug 20(R)-ginsenoside Rg3 is a white solid powder; the taste is slightly bitter.

Embodiment 2

[0323] Example 2 bulk drug 20 (R)-ginsenoside Rg3 quality standard detection

[0324] 1. Determination of 20(R)-ginsenoside Rg3 content

[0325] 1-1) Take an appropriate amount of 20(R)-ginsenoside Rg3 reference substance, grind it finely, accurately weigh 20(R)-ginsenoside Rg3 reference substance (10 mg), add methanol-water mixed solution, dissolve it ultrasonically, and prepare Ginsenoside Rg3 reference substance solution containing 0.1 mg ginsenoside Rg3 per 1 ml;

[0326] 1-2) Take an appropriate amount of the 20(R)-ginsenoside Rg3 crude drug prepared in Example 1, grind it finely and precisely weigh the ginsenoside Rg3 sample (22.1mg), place it in a 100mL volumetric flask, add methanol-water to mix Appropriate amount of solution, shake well, after dissolving, put it in an ultrasonic instrument for ultrasonic treatment for 60 minutes, then cool to room temperature (15-35°C), add methanol-water to mix and dissolve to the scale line of the volumetric flask, shake well, and ...

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Abstract

The invention discloses a quality standard detection method for crude drug 20(R)-ginsenoside Rg3. The method includes: 1) identifying 20(R)-ginsenoside Rg3; 2) determining the content of 20(R)-ginsenoside Rg3; and 3) detecting related substances. The method provided by the invention is mainly used for quality control of 20(R)-ginsenoside Rg3 crude drug and its preparations, has the characteristics of simplicity, stability and good repeatability, is conducive to improving the inspection efficiency, and ensures the treatment effect of 20(R)-ginsenoside Rg3 crude drug and preparations.

Description

technical field [0001] The invention relates to a method for detecting the raw material of traditional Chinese medicine, in particular to a method for detecting the quality of the raw material of 20(R)-ginsenoside Rg3. Background technique [0002] Tumor is a new organism formed by the body's genetic and environmental carcinogenic factors in a coordinated manner, causing DNA damage and mutation in the genetic material, accompanied by the activation of multiple oncogenes and the inactivation of tumor suppressor genes, resulting in the continuous proliferation and transformation of normal cells. It is a systemic disorder characterized by localized abnormal proliferation of cells. According to the degree of harm to the human body, tumors are divided into two categories: benign tumors and malignant tumors. Malignant tumor cells can infiltrate and spread around, and even spread to other organs and tissues, and continue to multiply, posing a great threat to human life. [0003] ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90G01N30/02G01N5/04G01N21/21
CPCG01N5/04G01N21/21G01N30/02G01N30/90
Inventor 富力惠敏鲁岐鲁明明王凯乾
Owner 富力
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