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A kind of deep processing preparation and quality control method of propolis compound

A technology of propolis extract and propolis, which is applied in directions such as medical preparations without active ingredients, medical preparations containing active ingredients, and drug combinations, can solve problems such as poor properties of propolis powder, uniform mixing of auxiliary materials, and difficulty in drying. , to achieve the effect of good liquidity

Active Publication Date: 2019-11-12
BY HEALTH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] After propolis is extracted and concentrated by ethanol, the obtained extract is very viscous and is usually difficult to dry. In order to make the extract dry smoothly, it is necessary to add auxiliary materials to it, such as starch, maltodextrin, lactose, etc., but because the propolis extract contains There are also a large amount of tannin components such as gums and resins, which are relatively weak in polarity and bonded into agglomerates, which often cannot be mixed evenly with auxiliary materials, and then a uniform system cannot be obtained for the next drying process, resulting in poor powder properties of propolis powder. Poor, it cannot be uniformly mixed with other raw materials of the product formula, which ultimately affects the product preparation process; at the same time, because propolis contains a large number of compounds with aldehydes, ketones, phenolic hydroxyl groups, etc. The amine groups of gelatin will undergo condensation and cross-linking reactions with each other, resulting in the disintegration of propolis powder prepared by traditional techniques after being made into tablets, hard capsules, and soft capsules during the shelf life. A problem with the requirement that results in the product being judged as non-conforming

Method used

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  • A kind of deep processing preparation and quality control method of propolis compound
  • A kind of deep processing preparation and quality control method of propolis compound
  • A kind of deep processing preparation and quality control method of propolis compound

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preparation example Construction

[0043] The invention discloses a preparation method of propolis powder and a product thereof. Those skilled in the art can refer to the content of this article and appropriately improve the process parameters to realize it. In particular, it should be pointed out that all similar replacements and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The method and application of the present invention have been described through preferred embodiments, and the relevant personnel can obviously make changes or appropriate changes and combinations to the method and application described herein without departing from the content, spirit and scope of the present invention to realize and Apply the technology of the present invention.

[0044] The preparation method of the propolis powder provided by the invention and the raw materials or auxiliary materials used in the product can be purchased from the market.

Embodiment 1

[0046] The preparation of embodiment 1 propolis powder

[0047] 1. Pretreatment

[0048] Freezing the raw material of Brazilian green propolis at -20°C for 3 hours to harden the propolis; then crushing it with a pulverizer to obtain the raw material of propolis powder;

[0049] 2. Extraction

[0050] Take the pulverized propolis raw material, put it in an extraction tank, add 85% ethanol in an amount 4 times the volume of the medicinal material, stir and extract at room temperature for 3 hours, filter, and store the filtrate separately; , take the filtrate, and combine the extracts.

[0051] 3. Concentration and grinding

[0052]Test group: take the ethanol extract of propolis and concentrate it in a concentrator under reduced pressure. The vacuum degree is controlled at -0.01MPa and the temperature is 50°C. Centrifuge at a speed of 2000r / min for 5min, remove the suspended matter in the upper layer, take the centrifuge and continue to concentrate under reduced pressure unt...

Embodiment 2

[0062] The preparation of embodiment 2 propolis powder

[0063] 1. Pretreatment

[0064] Freezing the raw material of Brazilian green propolis at -20°C for 3 hours to harden the propolis; then crushing it with a pulverizer to obtain the raw material of propolis powder;

[0065] 2. Extraction

[0066] Take the pulverized propolis raw material, put it in an extraction tank, add 75% ethanol in an amount 10 times the volume of the medicinal material, stir and extract at room temperature for 2 hours, filter, and store the filtrate separately; , take the filtrate, and combine the extracts.

[0067] 3. Concentration and grinding

[0068] Test group: take the propolis ethanol extract and concentrate it in a concentrator under reduced pressure. The vacuum degree is controlled at -0.03MPa and the temperature is 60°C. Centrifuge at a speed of 1500r / min for 8min, remove the suspended matter in the upper layer, and then take the centrifuged liquid and continue to concentrate under redu...

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Abstract

The invention relates to the field of propolis product processing, and particularly relates to a deep processing preparation method for a propolis powder, and a product thereof. The preparation method comprises the following steps: hardening and crushing a propolis raw material to obtain a propolis raw material powder; carrying out alcohol extraction on the propolis raw material powder to obtain a thick propolis extract paste; and mixing the thick propolis extract paste with amino acid and auxiliary materials, grinding, carrying out freeze drying, and crushing to obtain the propolis powder. According to the preparation method disclosed by the invention, the mixing condition of propolis and the auxiliary materials is improved through adding the amino acid into the thick propolis extract paste, thus the propolis can be uniformly mixed with the auxiliary materials, and then the propolis can be smoothly dried to obtain the propolis powder with good powder characteristic; and meanwhile, the propolis powder prepared by the process is suitable for propolis capsules (comprising hard capsules and soft capsules), propolis tablets and the like, and is capable of remarkably improving the problem of disintegration of propolis products.

Description

technical field [0001] The invention relates to the field of propolis processing, in particular to a preparation method for deep processing of propolis products and products thereof. Background technique [0002] Propolis is a colloidal solid with an aromatic smell that is processed by bees from the resin collected from plant spores or tree trunks and mixed with the secretions of their palate glands and wax glands. It is a yellow-brown or dark-brown viscous substance secreted by Apis mellifera and other animals repairing the hive, which can be used as medicine. It is flat in nature, bitter, pungent, and slightly sweet. It has the effects of moisturizing skin and promoting muscle growth, reducing inflammation and relieving pain, and can treat gastric ulcers, oral ulcers, burns, skin cracks, and radiation protection. Over the years, it has been mainly used clinically for capillary hemostatic drugs and auxiliary antihypertensive drugs. In addition to flavonoids, propolis also...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/644A61K47/18A23L21/20A23L33/175A23P10/47A61P37/04A61P39/06
CPCA23V2002/00A61K35/644A61K47/183A23V2200/324A23V2200/30A23V2250/0606A23V2250/5114A23V2300/10A23V2250/0624A23V2250/063A23V2250/5112A23V2250/0616A23V2250/0632A23V2250/6412A23V2250/18A23V2250/712A23V2250/5432A23V2250/6406A23V2200/046A23V2250/1628
Inventor 何健黄远英殷光玲张铭辉斯聪聪
Owner BY HEALTH CO LTD
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