Medicine for treating lupus nephritis and preparation method and application thereof

A lupus nephritis and drug technology, applied in the field of medicine, can solve the problems of long treatment time and high disease recurrence rate, and achieve stable, consolidated and definite curative effects

Inactive Publication Date: 2017-03-22
郑州莉迪亚医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies in recent years have shown that the use of traditional Chinese medicine in the treatment of lupus nephritis can improve the curative effect and have low side effects, but the treatment time is long and the recurrence rate of the disease is high

Method used

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  • Medicine for treating lupus nephritis and preparation method and application thereof

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Comparison scheme
Effect test

Embodiment 1

[0018] In the embodiment of the present invention, a medicine for the treatment of lupus nephritis is composed of the following raw materials: 1 part of hexamethyldisilazane, 11 parts of difluorobenzenesalicylic acid, 13 parts of monosodium fumarate, perillyl alcohol 8 servings.

[0019] Mix and grind difluorobenzenesalicylic acid and monosodium fumarate, then add deionized water with 4.5 times the mass of the two, heat to 75° C. and stir at this temperature for 25 minutes to prepare mixture A. The hexamethyldisilazane was put into the mixture A, and then sealed and stirred at a temperature of 88° C. for 33 min to prepare the mixture B. Then add perillyl alcohol, then ultrasonically treat for 15 minutes at a temperature of 63°C, and the ultrasonic power is 900W, then stir to dryness at a temperature of 75°C, and granulate to obtain the medicine.

Embodiment 2

[0021] In the embodiment of the present invention, a medicine for the treatment of lupus nephritis is composed of the following raw materials: 5 parts of hexamethyldisilazane, 19 parts of difluorobenzenesalicylic acid, 21 parts of monosodium fumarate, perillyl alcohol 16 servings.

[0022] Mix and grind difluorobenzenesalicylic acid and monosodium fumarate, then add deionized water with 4.5 times the mass of the two, heat to 75° C. and stir at this temperature for 28 minutes to prepare mixture A. Hexamethyldisilazane was put into mixture A, and then sealed and stirred at a temperature of 88° C. for 35 min to prepare mixture B. Then add perillyl alcohol, then ultrasonically treat for 15 minutes at a temperature of 63°C, and the ultrasonic power is 900W, then stir to dryness at a temperature of 75°C, and granulate to obtain the medicine.

Embodiment 3

[0024] In the embodiment of the present invention, a medicine for the treatment of lupus nephritis is composed of the following raw materials: 2 parts of hexamethyldisilazane, 13 parts of difluorobenzenesalicylic acid, 15 parts of monosodium fumarate, perillyl alcohol 10 servings.

[0025] Mix and grind difluorobenzenesalicylic acid and monosodium fumarate, then add deionized water with 4.5 times the mass of the two, heat to 75° C. and stir at this temperature for 26 minutes to prepare mixture A. Hexamethyldisilazane was put into mixture A, and then sealed and stirred at a temperature of 88° C. for 34 min to prepare mixture B. Then add perillyl alcohol, then ultrasonically treat for 15 minutes at a temperature of 63°C, and the ultrasonic power is 900W, then stir to dryness at a temperature of 75°C, and granulate to obtain the medicine.

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Abstract

The invention discloses a medicine for treating lupus nephritis and a preparation method and application thereof. The medicine is prepared from 1-5 parts of hexamethyl disilazane, 11-19 parts of diflunisal, 13-21 parts of monosodium fumarate and 8-16 parts of perillyl alcohol. Diflunisal and monosodium fumarate are mixed and ground, then deionized water is added, the mixture is heated to 75 DEG C and stirred at the temperature, and a mixture A is prepared; hexamethyl disilazane is placed into the mixture A, then the product is sealed and stirred at 88 DEG C, then perillyl alcohol is added, ultrasonic treatment is conducted for 15 min at 63 DEG C, then the product is stirred at 75 DEG C till the product is dry, granulation is conducted, and the medicine is obtained. The medicine is more remarkable in lupus nephritis treating effect, hormone is reduced easily, complications in the treatment process are reduced, the curative effect is enhanced, remarkable, obvious and stable, use is safe and convenient, no toxic and side effects are caused, lupus nephritis does not relapse after healing, the price is low, and the medicine is worthy of clinical popularization.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medicine for treating lupus nephritis and a preparation method and application thereof. Background technique [0002] Lupus nephritis refers to a disease in which systemic lupus erythematosus (SLE) is combined with immune damage of different pathological types of both kidneys and is accompanied by clinical manifestations of obvious renal damage. Its pathogenesis is related to the formation of immune complexes, immune cells and cytokines and other immune abnormalities. In addition to the systemic manifestations of SLE, the main clinical manifestations are hematuria, proteinuria, and renal insufficiency. The pathological classification of lupus nephritis is of great value for judging disease activity and prognosis, and formulating treatment plans. Treatment plans should be individualized according to the severity of the disease. The pathogenesis of lupus nephritis may be rela...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/695A61K9/16A61P13/12A61K31/045A61K31/194A61K31/60
CPCA61K31/695A61K9/1605A61K31/045A61K31/194A61K31/60A61K2300/00
Inventor 不公告发明人
Owner 郑州莉迪亚医药科技有限公司
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