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Preparation method of polyvinyl alcohol microspheres

A technology of polyvinyl alcohol microspheres and polyvinyl alcohol, which is applied in the field of preparation of polyvinyl alcohol microspheres, can solve the problems of large particle size, uneven size, and complicated preparation methods of microspheres, and achieve uniform particle size distribution and shape Complete smooth, easy-to-use effect

Inactive Publication Date: 2017-03-15
SHAANXI YIPINDA PETROCHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current preparation method of polyvinyl alcohol microspheres is complicated, and the obtained microspheres have large particle size and uneven size.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation method of polyvinyl alcohol microspheres includes the following steps:

[0019] (1) According to the mass concentration of 2.5%, weigh the polyvinyl alcohol, dissolve it in deionized water, let it stand for 30 minutes, then raise the temperature to 80°C and stir for 30 minutes;

[0020] (2) Add the solution of step (1) to vegetable oil containing sorbitan trioleate according to a volume ratio of 2:1, and stir at 60°C for 30 minutes;

[0021] (3) Add glutaraldehyde to the product of step (2), where the mass ratio of glutaraldehyde to polyvinyl alcohol is 1:9. After stirring for 10 minutes, add sorbitan monooleate and continue stirring for 1 hour. , Then ultrasonic treatment for 1h under the condition of ultrasonic power of 200W;

[0022] (4) Centrifuge the product of step (3) for 50 min at 2000 rpm to separate the precipitate. Wash the precipitate with acetone and deionized water 3 times, and finally with acetone 3 times, and vacuum dry the resulting product. Th...

Embodiment 2

[0024] The preparation method of polyvinyl alcohol microspheres includes the following steps:

[0025] (1) According to the mass concentration of 10%, weigh polyvinyl alcohol, dissolve it in deionized water, let it stand for 30 minutes, then use the heating rate of 10°C / min, raise the temperature to 80°C, and stir for 30 minutes;

[0026] (2) Add the solution of step (1) to vegetable oil containing sorbitan trioleate according to a volume ratio of 2:1, where the mass ratio of sorbitan trioleate to vegetable oil is 1:60, Stir at 80°C for 30min;

[0027] (3) Add glutaraldehyde to the product of step (2), where the mass ratio of glutaraldehyde to polyvinyl alcohol is 1:9. After stirring for 10 minutes, add sorbitan monooleate and continue stirring for 1 hour. , Then ultrasonic treatment for 1h under the condition of ultrasonic power of 200W;

[0028] (4) Centrifuge the product of step (3) for 50 min at 2000 rpm to separate the precipitate. Wash the precipitate with acetone and deionized...

Embodiment 3

[0030] The preparation method of polyvinyl alcohol microspheres includes the following steps:

[0031] (1) Weigh polyvinyl alcohol according to the mass concentration of 5%, dissolve it in deionized water, let it stand for 30 minutes, and then heat it up to 80°C at a heating rate of 10°C / min, and stir for 30 minutes;

[0032] (2) Add the solution of step (1) to vegetable oil containing sorbitan trioleate according to a volume ratio of 2:1, where the mass ratio of sorbitan trioleate to vegetable oil is 1:60, Stir at 70°C for 30min;

[0033] (3) Add glutaraldehyde to the product of step (2), where the mass ratio of glutaraldehyde to polyvinyl alcohol is 1:9. After stirring for 10 minutes, add sorbitan monooleate, and add dehydration The mass of sorbitol monooleate is 0.03 times the mass of polyvinyl alcohol, after continuous stirring for 1 hour, then ultrasonic treatment is carried out for 1 hour under the condition of ultrasonic power of 200W;

[0034] (4) Centrifuge the product of st...

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PUM

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Abstract

The invention discloses a preparation method of polyvinyl alcohol microspheres. The method comprises the following steps: dissolving polyvinyl alcohol into deionized water, standing for 30min, raising the temperature to 80 DEG C, and performing stirring for 30min; adding a product into plant oil containing sorbitan trioleate, and performing stirring for 30min at the temperature of 60-80 DEG C; adding glutaraldehyde, performing stirring for 10min, adding sorbitan oleate, performing continuous stirring for 1h, performing ultrasonic treatment and centrifugal separation precipitation, and cleaning for 3 times by using acetone and the deionized water respectively; finally, cleaning for 3 times by using the acetone, and performing vacuum drying on an obtained product to obtain white powder namely the polyvinyl alcohol microspheres. The preparation method of the polyvinyl alcohol microspheres is simple in operation, the prepared microspheres are uniform in particle size distribution, the average particle size is 15-45 microns, the shape is complete and smooth, and the dispersity is good.

Description

Technical field [0001] The invention belongs to the field of preparation of biological materials, and specifically relates to a preparation method of polyvinyl alcohol microspheres. Background technique [0002] Polyvinyl alcohol (PVA) is a water-soluble polymer synthesized by human T. Because of its good formability, non-toxicity, good biocompatibility, and biodegradability, it is used in biomedicine such as cartilage, artificial cornea, drug sustained release, etc. Field mouth. However, from the research status at home and abroad, most of the current research on this material is limited to making PVA into the form of a hydrogel film, and then to evaluate its feasibility as an artificial joint cartilage material. On the contrary, there is relatively little research on other forms of PVA materials, which will inevitably greatly limit the application of this material in the field of biomedicine. [0003] Compared with materials in the form of hydrogels, porous scaffolds, membranes...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/14C08L29/04
CPCC08J3/242C08J3/14C08J2329/04
Inventor 李长英
Owner SHAANXI YIPINDA PETROCHEM CO LTD
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